Ruoli Chen
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View article: Microglia-Mediated Phagocytosis in Alzheimer’s Disease: Mechanisms, Heterogeneity, and Therapeutic Insights
Microglia-Mediated Phagocytosis in Alzheimer’s Disease: Mechanisms, Heterogeneity, and Therapeutic Insights Open
Microglia are the resident immune cells of the CNS, maintaining brain homeostasis partially through phagocytosis. In Alzheimer’s disease (AD), microglial phagocytosis is significantly impaired, contributing to the accumulation of pathologi…
View article: Astrocyte-Conditioned Medium Induces Protection Against Ischaemic Injury in Primary Rat Neurons
Astrocyte-Conditioned Medium Induces Protection Against Ischaemic Injury in Primary Rat Neurons Open
Background: Astrocytes are not only structural cells but also play a pivotal role in neurogenesis and neuroprotection by secreting a variety of neurotrophic factors that support neuronal survival, growth, and repair. This study investigate…
View article: Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis
Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis Open
Multiple sclerosis (MS) is an autoimmune disease that damages the myelin sheath around the central nervous system axons, leading to neurological dysfunction. Although the initial damage is driven by inflammation, hypoxia has been reported …
View article: Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma
Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma Open
Aquaporin 4 (AQP4) is abundant in the human brain and has an important role in brain homeostasis and diseases. AQP4 expression has been found to be associated with glioma malignancies. However, the complete understanding of the biological …
View article: The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons
The Duration of Oxygen and Glucose Deprivation (OGD) Determines the Effects of Subsequent Reperfusion on Rat Pheochromocytoma (PC12) Cells and Primary Cortical Neurons Open
Reperfusion is the fundamental treatment for ischaemic stroke; however, many ischaemic stroke patients cannot undergo reperfusion treatment. Furthermore, reperfusion can cause ischaemic reperfusion injuries. This study aimed to determine t…
View article: Editorial: Neuroinflammation in hypoxia and ischaemia
Editorial: Neuroinflammation in hypoxia and ischaemia Open
EDITORIAL article Front. Mol. Biosci., 07 November 2022Sec. Cellular Biochemistry https://doi.org/10.3389/fmolb.2022.1066818
View article: Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture
Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture Open
Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…
View article: Astrocytic aquaporin 4 subcellular translocation as a therapeutic target for cytotoxic edema in ischemic stroke
Astrocytic aquaporin 4 subcellular translocation as a therapeutic target for cytotoxic edema in ischemic stroke Open
Brain edema is a common feature of several brain diseases (e.g., stroke, traumatic brain injury, hydrocephalus, brain cancer, and brain infections). Brain edema leads to increased intracranial pressure and worsens outcomes in ischemic stro…
View article: Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke
Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke Open
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clin…
View article: Pharmacological properties of rutin and its potential uses for Alzheimer???s disease
Pharmacological properties of rutin and its potential uses for Alzheimer???s disease Open
Rutin, a flavonoid with a wide range of biological activities, has a long history of use in nutritional supplements owing to its action against oxidative stress, inflammation, and hyperglycemia. Because of its pharmacological properties su…
View article: Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy
Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy Open
Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. Microglia become “activated”, proliferating, and undergoing changes in morphology, ge…
View article: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model Open
This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxic…
View article: Editorial: The Development of New Classes of Hypoxia Mimetic Agents for Clinical Use
Editorial: The Development of New Classes of Hypoxia Mimetic Agents for Clinical Use Open
EDITORIAL article Front. Cell Dev. Biol., 26 June 2019Sec. Cellular Biochemistry Volume 7 - 2019 | https://doi.org/10.3389/fcell.2019.00120
View article: Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors
Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors Open
Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is as…
View article: Pharmacological Modulation of Autophagy for Neuroprotection in Ischaemic Stroke
Pharmacological Modulation of Autophagy for Neuroprotection in Ischaemic Stroke Open
Autophagy is a highly regulated, catabolic process, through which macromolecules such as damaged organelles and proteins are degraded and recycled to maintain cellular homeostasis. Various studies have shown the role of autophagy activatio…
View article: Effects of transthyretin on thyroxine and β‐amyloid removal from cerebrospinal fluid in mice
Effects of transthyretin on thyroxine and β‐amyloid removal from cerebrospinal fluid in mice Open
Summary Transthyretin ( TTR ) is a binding protein for the thyroid hormone thyroxine (T 4 ), retinol and β‐amyloid peptide. TTR aids the transfer of T 4 from the blood to the cerebrospinal fluid ( CSF ), but also prevents T 4 loss from the…
View article: Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study
Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study Open
Objective To assess the association of socioeconomic deprivation (SED) with survival after stroke in China. Design A systematic literature review and a new population-based cohort study. Setting and participants In urban and rural communit…