Ruolin Mao
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View article: The mechanism and protective strategies of follicle injury after ovarian tissue cryopreservation and thawed transplantation: a review
The mechanism and protective strategies of follicle injury after ovarian tissue cryopreservation and thawed transplantation: a review Open
View article: P-181 Inflammation triggered in SLE impairs female fertility accompanied by compromised oocyte developmental competence via over-oxidative stress induced mitochondrial imbalance
P-181 Inflammation triggered in SLE impairs female fertility accompanied by compromised oocyte developmental competence via over-oxidative stress induced mitochondrial imbalance Open
Study question What are the underlying mechanisms by which SLE impairs oocyte developmental potential Summary answer This study identified SLE-associated inflammation as a driver of oocyte mitochondrial dysfunction via oxidative stress, di…
View article: O-143 The optimal time identification in patients with oocyte vitrification for a better cumulative live birth rate
O-143 The optimal time identification in patients with oocyte vitrification for a better cumulative live birth rate Open
Study question What is the optimal time window in prepared operation of oocyte vitrification to gain better reproductive outcomes as well as cumulative live birth rate? Summary answer The combined time window of 90-135min for oocyte pick u…
View article: A causal effects of neutrophil extracellular traps and its biomarkers on acute respiratory distress syndrome: a two-sample Mendelian randomization study
A causal effects of neutrophil extracellular traps and its biomarkers on acute respiratory distress syndrome: a two-sample Mendelian randomization study Open
Previous studies have indicated an association between neutrophil extracellular traps (NETs) and acute respiratory distress syndrome (ARDS). This study aimed to investigate the potential causal effects of NETs and NETs-related biomarkers o…
View article: Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study
Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study Open
Introduction Previous studies have established a link between gut microbiota and polycystic ovary syndrome (PCOS), but little is known about their precise causal relationship. Therefore, this study aims to explore whether there are precise…
View article: A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility
A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility Open
Pannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions. Variants in the PANX1 gene have been reported to be associated with …
View article: Recryopreservation impairs blastocyst implantation potential via activated endoplasmic reticulum stress pathway and induced apoptosis
Recryopreservation impairs blastocyst implantation potential via activated endoplasmic reticulum stress pathway and induced apoptosis Open
Recryopreservation (recryo) is occasionally applied in clinical, while the underlying mechanism of impaired clinical outcomes after recryo remains unclear. In this study, frozen embryo transfer (FET) cycles of single blastocyst transfer in…
View article: A new insight on evaluation of the fertility and pregnancy outcome in patients with primary Sjögren syndrome: a propensity score matched study in multi-IVF centers
A new insight on evaluation of the fertility and pregnancy outcome in patients with primary Sjögren syndrome: a propensity score matched study in multi-IVF centers Open
Background Primary Sjögren syndrome (pSS) is often related to adverse neonatal outcomes. But it’s currently controversial whether pSS has an adverse effect on female fertility and clinical pregnancy condition. More importantly, it’s unclea…
View article: Decreased embryo developmental potential and lower cumulative pregnancy rate in men with multiple morphological abnormalities of the sperm flagella
Decreased embryo developmental potential and lower cumulative pregnancy rate in men with multiple morphological abnormalities of the sperm flagella Open
Objective Multiple morphological abnormalities of the sperm flagella (MMAF) is characterized by abnormal flagellar phenotypes, which is a particular kind of asthenoteratozoospermia. Previous studies have reported a comparable intracytoplas…
View article: The genetic relationship between systemic lupus erythematosus and risk of primary ovarian failure from a mendelian randomization study
The genetic relationship between systemic lupus erythematosus and risk of primary ovarian failure from a mendelian randomization study Open
View article: TRPA1-PI3K/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury
TRPA1-PI3K/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury Open
Exposure to ozone induces mitochondrial dysfunction in human bronchial epithelial cells and mouse lungs by activating TRPA1, which results in ferroptosis mediated via a PI3K/Akt/OPA1 axis. This supports a potential role of TRPA1 blockade i…
View article: Serum Metabolomics Reveals Metabolomic Profile and Potential Biomarkers in Asthma
Serum Metabolomics Reveals Metabolomic Profile and Potential Biomarkers in Asthma Open
Collectively, asthmatic patients showed a unique serum metabolome. Sphingolipid metabolism and valine, leucine and isoleucine biosynthesis were involved in the pathogenesis of asthma. Furthermore, our results suggest the promising values o…
View article: An overview of CFTR mutation profiles and assisted reproductive technology outcomes in Chinese patients with congenital obstructive azoospermia
An overview of CFTR mutation profiles and assisted reproductive technology outcomes in Chinese patients with congenital obstructive azoospermia Open
View article: Peripheral neutrophils and oxidative stress-associated molecules for predicting the severity of asthma: a cross-sectional study based on multidimensional assessment
Peripheral neutrophils and oxidative stress-associated molecules for predicting the severity of asthma: a cross-sectional study based on multidimensional assessment Open
Objectives This study aims to explore the relationship between the severity of asthma and neutrophils and related oxidative stress-associated molecules in peripheral blood and induced sputum. Methods A total of 67 subjects were included in…
View article: gut microbiota and PCOS
gut microbiota and PCOS Open
Supplementary documentation
View article: The Genetic Relationship between Systemic Lupus Erythematosus and Risk of Primary Ovarian Failure: a Two-sample Mendelian Randomization Study
The Genetic Relationship between Systemic Lupus Erythematosus and Risk of Primary Ovarian Failure: a Two-sample Mendelian Randomization Study Open
Background Previous studies investigating the relationship between systemic lupus erythematosus (SLE) and primary ovarian failure (POF) generated conflicting results, especially with the existence of potential environmental confounders. To…
View article: CC16 as an Inflammatory Biomarker in Induced Sputum Reflects Chronic Obstructive Pulmonary Disease (COPD) Severity
CC16 as an Inflammatory Biomarker in Induced Sputum Reflects Chronic Obstructive Pulmonary Disease (COPD) Severity Open
PURPOSE: The progression of an abnormal inflammatory response plays a crucial role in the lung function decline of chronic obstructive pulmonary disease (COPD) patients. Compared to serum biomarkers, inflammatory biomarkers in induced sput…
View article: A new insight into the impact of systemic lupus erythematosus on oocyte and embryo development as well as female fertility
A new insight into the impact of systemic lupus erythematosus on oocyte and embryo development as well as female fertility Open
Background Systemic lupus erythematosus (SLE) is often associated with adverse reproductive outcomes. But it’s currently unclear regarding the role of SLE in oocyte and embryonic development. Also, it’s controversial whether SLE has an adv…
View article: Medium-long term prognosis prediction for idiopathic pulmonary fibrosis patients based on quantitative analysis of fibrotic lung volume
Medium-long term prognosis prediction for idiopathic pulmonary fibrosis patients based on quantitative analysis of fibrotic lung volume Open
View article: Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway
Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway Open
The current asthma therapies are inadequate for many patients with severe asthma. Pyrroloquinoline quinone (PQQ) is a naturally-occurring redox cofactor and nutrient that can exert a multitude of physiological effects, including anti-infla…
View article: Stable Chronic Obstructive Pulmonary Disease (COPD) Management Under a Tiered Medical System in China
Stable Chronic Obstructive Pulmonary Disease (COPD) Management Under a Tiered Medical System in China Open
Ruolin Mao,1,* Zilong Liu,1,* Yunfeng Zhao,2,* Chunlin Du,3,* Jintao Zhou,4,* Qian Wang,5,* Jinchang Lu,3 Lei Gao,1 Bo Cui,1 Yuan Ma,1 Tieying Sun,6 Lei Zhu,1,7 Zhihong Chen1 1Department of Respiratory and Critical Care Medicine, Zhongshan…
View article: Lipopolysaccharide-Activated Bone Marrow-Derived Dendritic Cells Suppress Allergic Airway Inflammation by Ameliorating the Immune Microenvironment
Lipopolysaccharide-Activated Bone Marrow-Derived Dendritic Cells Suppress Allergic Airway Inflammation by Ameliorating the Immune Microenvironment Open
Background Previous studies have shown that lipopolysaccharide (LPS)-activated bone marrow-derived dendritic cells (DClps) might induce tolerance in autoimmune and cancer models in vivo , whereas it remains unclear whether DClps could play…
View article: Stable Chronic Obstructive Pulmonary Disease (COPD) Management Under a Tiered Medical System in China
Stable Chronic Obstructive Pulmonary Disease (COPD) Management Under a Tiered Medical System in China Open
Background: Early diagnosis and proper management of a large number of chronic obstructive pulmonary disease (COPD) patients are great challenges for the Chinese health care system. Although tiered medical services have been promoted by th…
View article: Advances in Drug Therapy for Alzheimer’s Disease
Advances in Drug Therapy for Alzheimer’s Disease Open
Summary Alzheimer’s disease (AD) is a chronic neurodegenerative disease that mainly causes dementia. It is a serious threat to the health of the global elderly population. Considerable money and effort has been invested in the development …
View article: Inflammatory Biomarkers in induced Sputum Predict Chronic Obstructive Pulmonary Disease (COPD) Severity
Inflammatory Biomarkers in induced Sputum Predict Chronic Obstructive Pulmonary Disease (COPD) Severity Open
Background: The progression of an abnormal inflammatory response plays a crucial role in the functional decline that occurs in COPD patients[1].Compared to serum biomarkers, inflammatory biomarkers in induced sputum would be a more reliabl…
View article: Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine
Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine Open
View article: Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro
Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro Open
Background Mounting evidence, consistent with our previous study, showed that γ-aminobutyric acid type A receptor (GABAAR) played an indispensable role in airway inflammation and mucus hypersecretion in asthma. Monocyte chemotactic protein…
View article: Adoptive transfer of bone marrow-derived dendritic cells (BMDCs) alleviates OVA-induced allergic airway inflammation in asthmatic mice
Adoptive transfer of bone marrow-derived dendritic cells (BMDCs) alleviates OVA-induced allergic airway inflammation in asthmatic mice Open
Airway dendritic cells (DCs) are recognized as important factors in the mechanisms of allergic inflammatory diseases. Suppressor of cytokine signaling 3 (SOCS3) is involved in regulating the functions of T cells and macrophages, but the ro…
View article: Lipopolysaccharide-activated bone marrow-derived dendritic cells suppress ovalbumin(OVA)-induced asthma by ameliorating the immune microenvironment
Lipopolysaccharide-activated bone marrow-derived dendritic cells suppress ovalbumin(OVA)-induced asthma by ameliorating the immune microenvironment Open
LPS produced by Gram-negative bacteria effectively stimulates the maturation of BMDCs. Previous studies have shown that DClps might induce tolerance in autoimmune diseases and cancer in vivo, whereas it remains unclear whether DClps can mo…
View article: PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma Open
Background Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide‐3‐kinase (PI3K) activation, contributing to the development of GC insensitivity in chronic airway…