Ruonan Zhao
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View article: Characterization of fosS, a novel fosfomycin-modifying enzyme gene identified in Staphylococcus haemolyticus
Characterization of fosS, a novel fosfomycin-modifying enzyme gene identified in Staphylococcus haemolyticus Open
The efficacy of fosfomycin is increasingly challenged by emerging resistance mechanisms, primarily involving fosfomycin-modifying enzymes and target (MurA) alterations. This study aimed to elucidate the novel mechanism underlying fosfomyci…
View article: Development of the CRISPR/Cas9 system for genome editing in Riemerella anatipestifer
Development of the CRISPR/Cas9 system for genome editing in Riemerella anatipestifer Open
Riemerella anatipestifer (R. anatipestifer) is an important pathogen responsible for high mortality rates and severe economic losses in the poultry industry. Research on R. anatipestifer is constrained by limited genetic manipulation tools…
View article: Cell extrusion drives neural crest cell delamination
Cell extrusion drives neural crest cell delamination Open
Neural crest cells (NCC) comprise a heterogeneous population of cells with variable potency that contribute to nearly every tissue and organ throughout the body. Considered unique to vertebrates, NCC are transiently generated within the do…
View article: NR6A1 is essential for neural crest cell specification, formation and survival
NR6A1 is essential for neural crest cell specification, formation and survival Open
Neural crest cells (NCC) are a migratory progenitor cell population considered unique to vertebrates. Derived from the neuroepithelium during early embryogenesis, NCC contribute to nearly every tissue and organ system throughout the body, …
View article: Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans
Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans Open
We define a novel developmental syndrome associated with biallelic hypomorphic variants in DHRS3; a careful assessment of individual variants is required to establish a causal link to phenotype.
View article: Author response: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Author response: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
View article: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in developmental and pathological processes. Although originally considered a binary event, EMT i…
View article: Author Response: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Author Response: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Reviewer #3 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Reviewer #3 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Reviewer #2 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Reviewer #2 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Reviewer #1 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Reviewer #1 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Cell extrusion - a novel mechanism driving neural crest cell delamination
Cell extrusion - a novel mechanism driving neural crest cell delamination Open
Neural crest cells (NCC) comprise a heterogeneous population of cells with variable potency, that contribute to nearly every tissue and organ system throughout the body. Considered unique to vertebrates, NCC are transiently generated withi…
View article: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in developmental and pathological processes. Although originally considered a binary event, EMT i…
View article: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Reviewer #2 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Reviewer #2 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Reviewer #1 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Reviewer #1 (Public Review): Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination
Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination Open
Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, …
View article: Core and variable antimicrobial resistance genes in the gut microbiomes of Chinese and European pigs
Core and variable antimicrobial resistance genes in the gut microbiomes of Chinese and European pigs Open
Monitoring the prevalence of antimicrobial resistance genes (ARGs) is vital for addressing the global crisis of antibiotic-resistant bacterial infections. Despite its importance, the characterization of ARGs and microbiome structures, as w…
View article: Credit Default Prediction Based on Multivariate Regression
Credit Default Prediction Based on Multivariate Regression Open
Credit default is a wide-spread credit derivative instrument.As it becomes more and more popular, an appropriate supervision system has to be established.In this paper, a multiple factor regression models are constructed in order to invest…
View article: Insights into the effects of pulsed antimicrobials on the chicken resistome and microbiota from fecal metagenomes
Insights into the effects of pulsed antimicrobials on the chicken resistome and microbiota from fecal metagenomes Open
Antimicrobial resistance has become a global problem that poses great threats to human health. Antimicrobials are widely used in broiler chicken production and consequently affect their gut microbiota and resistome. To better understand ho…
View article: Risk Identification and Coping Strategy Analysis of Listed Companies' Capital Management Under the Centralized Management Mode
Risk Identification and Coping Strategy Analysis of Listed Companies' Capital Management Under the Centralized Management Mode Open
In order to improve their competitiveness in the market, listed companies have transformed from the original single production management to the centralized production management mode, and realized the optimization and integration of the i…
View article: Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development
Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development Open
Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-spec…
View article: The co‐occurrence of antibiotic resistance genes between dogs and their owners in families
The co‐occurrence of antibiotic resistance genes between dogs and their owners in families Open
The intimate relationship between humans and companion animals causes a unique and critical aspect of antimicrobial resistance in humans. However, a comprehensive analysis of antimicrobial resistance between companion animals and their own…
View article: Targeted Elimination of blaNDM-5 Gene in Escherichia coli by Conjugative CRISPR-Cas9 System
Targeted Elimination of blaNDM-5 Gene in Escherichia coli by Conjugative CRISPR-Cas9 System Open
The CRISPR-Cas9 system achieved plasmid clearance and simultaneous re-sensitization to meropenem in E. coli. The CRISPR-Cas9 system could block the horizontal transfer of plasmid pNDM-5. The conjugative delivery of CRISPR-Cas9 provi…
View article: Metagenomic Insights into Chicken Gut Antibiotic Resistomes and Microbiomes
Metagenomic Insights into Chicken Gut Antibiotic Resistomes and Microbiomes Open
The prevalence of antibiotic resistance genes in the chicken gut environment poses a serious threat to human health; however, we lack a comprehensive exploration of antibiotic resistomes and microbiomes in the chicken gut environment. The …
View article: The Fitting Optimization Path Analysis on Scale Missing Data: Based on the 507 Patients of Poststroke Depression Measured by SDS
The Fitting Optimization Path Analysis on Scale Missing Data: Based on the 507 Patients of Poststroke Depression Measured by SDS Open
Objective. To explore the optimal fitting path of missing data of the Scale to make the fitting data close to the real situation of patients’ data. Methods. Based on the complete data set of the SDS of 507 patients with stroke, the data si…
View article: Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development
Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development Open
Ribosomal RNA (rRNA) transcription by RNA Polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-spec…
View article: A reference gene catalogue of chicken gut antibiotic resistomes
A reference gene catalogue of chicken gut antibiotic resistomes Open
Background: The chicken gut microbiota, as a reservoir of antibiotic resistance genes (ARGs), poses a high risk to humans and animals worldwide. Yet a comprehensive exploration of the chicken gut antibiotic resistomes remains incomplete. R…
View article: Chlortetracycline promotes differentiation of intestinal bacterial community in broiler chicken
Chlortetracycline promotes differentiation of intestinal bacterial community in broiler chicken Open
Background Chlortetracycline is widely used for disease treatment and prevention in animal production system. However, the impact of chlortetracycline on gastrointestinal tract microbial communities of growing chickens has not been fully e…