Ruoping Chen
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View article: RP105 exerts hepatoprotective effects in sepsis by modulating the SOCS2/JAK2/STAT3 signaling pathway
RP105 exerts hepatoprotective effects in sepsis by modulating the SOCS2/JAK2/STAT3 signaling pathway Open
Sepsis‑induced liver injury increases mortality through inflammatory dysregulation. Although Radioprotective 105 (RP105) modulates inflammation, its role in septic liver injury remains unclear. The present study investigates the mechanism …
View article: BTBD10 inhibits glioma tumorigenesis by downregulating cyclin D1 and p-Akt
BTBD10 inhibits glioma tumorigenesis by downregulating cyclin D1 and p-Akt Open
The aim of this study was to investigate the role of BTBD10 in glioma tumorigenesis. The mRNA and protein levels of BTBD10 in 52 glioma tissues and eight normal brain tissues were determined using reverse transcription polymerase chain rea…
View article: Metabolomic Characterization of Cerebrospinal Fluid from Intracranial Bacterial Infection Pediatric Patients: A Pilot Study
Metabolomic Characterization of Cerebrospinal Fluid from Intracranial Bacterial Infection Pediatric Patients: A Pilot Study Open
Intracranial bacterial infection remains a major cause of morbidity and mortality in neurosurgical cases. Metabolomic profiling of cerebrospinal fluid (CSF) holds great promise to gain insights into the pathogenesis of central neural syste…
View article: Establishment of a prognostic-related microRNAs risk model for glioma by bioinformatics analysis
Establishment of a prognostic-related microRNAs risk model for glioma by bioinformatics analysis Open
Seven miRNAs which regulate target genes to participate in related signaling pathways and lead to a poor prognosis were identified as biomarkers of glioma.
View article: Hypoxia- and dexamethasone-dependent HIF1α-glucocorticoid receptor interaction leads to degradation of glucocorticoid receptor in pituitary adenomas.
Hypoxia- and dexamethasone-dependent HIF1α-glucocorticoid receptor interaction leads to degradation of glucocorticoid receptor in pituitary adenomas. Open
Cushing disease has a very high mortality rate and glucocorticoid resistance caused by GR down-regulation is one major reason of mortality. Although HIF1α signaling and GR signaling are involved in the pathogenesis of pituitary adenomas, i…
View article: A Biomimetic Plasmonic Nanoreactor for Reliable Metabolite Detection
A Biomimetic Plasmonic Nanoreactor for Reliable Metabolite Detection Open
Reliable monitoring of metabolites in biofluids is critical for diagnosis, treatment, and long‐term management of various diseases. Although widely used, existing enzymatic metabolite assays face challenges in clinical practice primarily d…
View article: Bacteria Inhibition: Detection and Inhibition of Bacteria on a Dual‐Functional Silver Platform (Small 3/2019)
Bacteria Inhibition: Detection and Inhibition of Bacteria on a Dual‐Functional Silver Platform (Small 3/2019) Open
In article number 1803051, Kun Qian and co-workers construct a dual-functional silver platform for the detection and inhibition of bacteria, toward real case applications and biological understandings. The designed platform achieves define…
View article: Application of osteoinductive calcium phosphate ceramics in children’s endoscopic neurosurgery: report of five cases
Application of osteoinductive calcium phosphate ceramics in children’s endoscopic neurosurgery: report of five cases Open
This work aimed at investigating the possibility and effectiveness of osteoinductive calcium phosphate (CaP) ceramics to close the drilled skull holes and prevent the postoperative cerebrospinal fluid (CSF) leaking in children's endoscopic…
View article: Metabolic Fingerprinting on a Plasmonic Gold Chip for Mass Spectrometry Based <i>in Vitro</i> Diagnostics
Metabolic Fingerprinting on a Plasmonic Gold Chip for Mass Spectrometry Based <i>in Vitro</i> Diagnostics Open
Current metabolic analysis is far from ideal to engage clinics and needs rationally designed materials and device. Here we developed a novel plasmonic chip for clinical metabolic fingerprinting. We first constructed a series of chips with …