Ruotong Zhang
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View article: Revealing sphingolipid metabolism genes as biomarkers for the diagnosis of invasive pituitary adenomas in silico and in vivo
Revealing sphingolipid metabolism genes as biomarkers for the diagnosis of invasive pituitary adenomas in silico and in vivo Open
This study identifies key genes potentially involved in the development and progression of IPA, offering new insights into the molecular mechanisms underlying IPA pathogenesis.
View article: Identification, structural features, and potential functional significance of the myodural Bridge in African clawed frog, the Xenopus laevis
Identification, structural features, and potential functional significance of the myodural Bridge in African clawed frog, the Xenopus laevis Open
View article: An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease
An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease Open
The anticipated rise in the prevalence of Alzheimer's disease (AD) under global demographic shifts necessitates the development of universally accessible screening and diagnostic tools, of which blood tests hold the promise. However, the w…
View article: Force-dependent development of the myodural bridge in rats: The impact of Integrin α7
Force-dependent development of the myodural bridge in rats: The impact of Integrin α7 Open
The myodural bridge (MDB) represents specialized fibrous structures establishing connectivity between suboccipital musculature and the spinal dura mater (SDM). The suboccipital muscles, ligaments, and myodural bridge fibers together form a…
View article: Fluidic-manipulation-enabled multiplexed dose delivery of RONS by a CAP chip for dose optimization enhancement
Fluidic-manipulation-enabled multiplexed dose delivery of RONS by a CAP chip for dose optimization enhancement Open
The plasma-derived reactive oxygen and nitrogen species (RONS) enable cold atmospheric plasma (CAP) to combat cancer and infectious wounds. Achieving therapeutic outcomes with CAP necessitates precise treatment doses. Current CAP devices a…
View article: Adverse childhood experiences and fertility intention among college students in China: moderated mediation effects of resilience and attachment
Adverse childhood experiences and fertility intention among college students in China: moderated mediation effects of resilience and attachment Open
Background The declining fertility rates and aging are becoming major demographic and public health challenges. According to the life course theory, an individual’s current fertility intention is shaped by past experiences, with adverse ch…
View article: Synergy of Micro‐Nano Engineering Templates and Additives for FAPbI<sub>3</sub>‐Based 1D Triangular Array Photodetector Fabrication
Synergy of Micro‐Nano Engineering Templates and Additives for FAPbI<sub>3</sub>‐Based 1D Triangular Array Photodetector Fabrication Open
In optoelectronic materials, 1D arrays play a significant role in augmenting optoelectronic properties. FAPbI 3 is highly regarded for its nearly theoretical optimal bandgap and remarkable optoelectronic performance. However, black‐phase m…
View article: Engineering the coordination environment of Ni and Pd dual active sites for promoting the oxygen reduction reaction
Engineering the coordination environment of Ni and Pd dual active sites for promoting the oxygen reduction reaction Open
View article: Group psychological counseling-based growth mindset intervention to promote active aging behaviors in older people: protocol for a randomized controlled trial
Group psychological counseling-based growth mindset intervention to promote active aging behaviors in older people: protocol for a randomized controlled trial Open
View article: Mn doped in SOD-BN: A half-metallic ferromagnet with high Curie temperature and large magnetic anisotropy
Mn doped in SOD-BN: A half-metallic ferromagnet with high Curie temperature and large magnetic anisotropy Open
Searching for practicable half-metallic ferromagnets (HMFs) with a high Curie temperature and large magnetic anisotropic energy is crucial for advancing next-generation spintronic devices. Here, we predict a promising material, Mn-doped so…
View article: A DIGITAL FERROFLUIDIC PLATFORM FOR OPERATING DIFFERENT FORMATS OF FERRO-DROPLETS
A DIGITAL FERROFLUIDIC PLATFORM FOR OPERATING DIFFERENT FORMATS OF FERRO-DROPLETS Open
View article: Sensitive Information Detection Based on Deep Learning Models
Sensitive Information Detection Based on Deep Learning Models Open
Currently, a large number of pornographic images on the Internet severely affect the growth of adolescents. In order to create a healthy and benign online environment, it is necessary to recognize and detect these sensitive images. Current…
View article: A droplet robotic system enabled by electret-induced polarization on droplet
A droplet robotic system enabled by electret-induced polarization on droplet Open
View article: LncRNA-004686 regulates muscle fibre type switching in chicken embryos by affecting the expression of MYH1B
LncRNA-004686 regulates muscle fibre type switching in chicken embryos by affecting the expression of MYH1B Open
Muscle fibres constitute the majority of an animal's muscle, and the kind of muscle fibres has a substantial impact on the quality of muscle. Long non-coding RNAs (lncRNAs) are well-known to participate in various critical regulatory proce…
View article: Identification of an SCF Ubiquitin Ligase Complex that Contributes to Resistance Against Valsa Canker in Apple
Identification of an SCF Ubiquitin Ligase Complex that Contributes to Resistance Against Valsa Canker in Apple Open
E3 ubiquitin ligases play a critical role in plant disease resistance. Among them, the Skp1-Cullin-F-box protein (SCF) ubiquitin ligase complex is the largest family and regulates the ubiquitination of a wide range of proteins. Apple Valsa…
View article: The volatility mechanism and intelligent fusion forecast of new energy stock prices
The volatility mechanism and intelligent fusion forecast of new energy stock prices Open
The new energy industry is strongly supported by the state, and accurate forecasting of stock price can lead to better understanding of its development. However, factors such as cost and ease of use of new energy, as well as economic situa…
View article: Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls
Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls Open
In vascular networks, the transport across different vessel walls regulates chemical compositions in blood over space and time. Replicating such trans-wall transport with spatial heterogeneity can empower synthetic fluidic systems to progr…
View article: Integrin α7 regulates the development of the myodural bridge complex in rats
Integrin α7 regulates the development of the myodural bridge complex in rats Open
The myodural bridge (MDB) is a fibrous structure that connects the suboccipital musculature to the cervical spinal dura mater (SDM) via the atlanto-occipital and atlanto-axial interspaces. Muscles, ligaments, and MDB fibers integrated a fu…
View article: Hybrid Stack Space Layout Randomization for Software Mtd
Hybrid Stack Space Layout Randomization for Software Mtd Open
View article: <i>MdVQ12</i> confers resistance to <i>Valsa mali</i> by regulating <i>MdHDA19</i> expression in apple
<i>MdVQ12</i> confers resistance to <i>Valsa mali</i> by regulating <i>MdHDA19</i> expression in apple Open
Valine‐glutamine (VQ) motif‐containing proteins play a crucial role in plant biotic stress responses. Apple Valsa canker, caused by the ascomycete Valsa mali , stands as one of the most severe diseases affecting apple trees. Nonetheless, t…
View article: Enhancing doctor-patient relationships in community health care institutions: the Patient Oriented Four Habits Model (POFHM) trial—a stepped wedge cluster randomized trial protocol
Enhancing doctor-patient relationships in community health care institutions: the Patient Oriented Four Habits Model (POFHM) trial—a stepped wedge cluster randomized trial protocol Open
Background The poor relationship between doctors and patients is a long-standing, global problem. However, current interventions tend to focus on the training of physicians, while patient-targeted interventions still need to be improved. C…
View article: Improving eye care quality through brief verbal intervention on optometry service provider by using unannounced standardized patient with refractive error: study protocol for a randomized controlled trial
Improving eye care quality through brief verbal intervention on optometry service provider by using unannounced standardized patient with refractive error: study protocol for a randomized controlled trial Open
Background Improper refractive correction can be harmful to eye health, aggravating the burden of vision impairment. During most optometry clinical consultations, practitioner-patient interactions play a key role. Maybe it is feasible for …
View article: PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction
PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction Open
Aging and obesity are the two prominent driving forces of metabolic dysfunction, yet the common underlying mechanisms remain elusive. PPARγ, a central metabolic regulator and primary drug target combatting insulin resistance, is hyperacety…
View article: Room-temperature ferromagnetic half metal in (C, Mn) co-doped orthorhombic ZnO with large magneto-crystalline anisotropy energy
Room-temperature ferromagnetic half metal in (C, Mn) co-doped orthorhombic ZnO with large magneto-crystalline anisotropy energy Open
Room-temperature ferromagnetic (FM) half-metallic materials are essential for spintronics applications. Here, we find that (C, Mn) co-doped orthorhombic ZnO (termed (C, Mn) @ Orth -ZnO) is a room-temperature FM half-metal with a magnetic m…
View article: FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis
FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis Open
Forkhead box protein O3 (FOXO3) has good inhibition ability toward fibroblast activation and extracellular matrix, especially for the treatment of idiopathic pulmonary fibrosis. How FOXO3 regulates pulmonary fibrosis remains unclear. In th…
View article: Effect of brief verbal intervention (BVI) on the quality of optometry service by using unannounced standardized patient (USP) with refractive error: study protocol for a randomized controlled trial (RCT)
Effect of brief verbal intervention (BVI) on the quality of optometry service by using unannounced standardized patient (USP) with refractive error: study protocol for a randomized controlled trial (RCT) Open
The authors have requested that this preprint be removed from Research Square.
View article: PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms Open
Systemic glucose metabolism and insulin activity oscillate in response to diurnal rhythms and nutrient availability with the necessary involvement of adipose tissue to maintain metabolic homeostasis. However, the adipose‐intrinsic regulato…
View article: Protective effect of Idelalisib on carbon tetrachloride‐induced liver fibrosis via microRNA‐124‐3P/phosphatidylinositol‐3‐hydroxykinase signalling pathway
Protective effect of Idelalisib on carbon tetrachloride‐induced liver fibrosis via microRNA‐124‐3P/phosphatidylinositol‐3‐hydroxykinase signalling pathway Open
Liver fibrosis is the repair process of abnormal connective tissue hyperplasia after liver damage caused by different causes. Inhibition of PI3K/Akt signalling pathway can reduce the deposition of extracellular matrix, inhibit the prolifer…
View article: FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis
FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis Open
Forkhead box protein O3 (FOXO3) has good inhibition ability toward fibroblast activation and extracellular matrix, especially for the treatment of idiopathic pulmonary fibrosis. How FOXO3 regulates pulmonary fibrosis remains unclear. In th…
View article: Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis
Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis Open