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View article: Comparative genomic and clinicopathological analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas
Comparative genomic and clinicopathological analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas Open
Thyroid tumors represent 1–4% of cancers in both dogs and humans. Most canine tumors are follicular (FTC) or medullary carcinomas (MTC), unlike humans, where only 10–15% are FTC and 2% are MTC, with BRAF/NRAS or RET mutations, respectively…
View article: Comparative multi-omics analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas
Comparative multi-omics analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas Open
Thyroid tumors represent 1-3% of canine cancers, with most tumors classified as follicular carcinomas and less frequently as medullary carcinomas. In comparison, only 10-15% of human thyroid cancers are follicular and 2% are medullary, wit…
View article: Supplementary Materials and Methods and Supplementary Tables S3, S4, S6, S8, and S9 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Supplementary Materials and Methods and Supplementary Tables S3, S4, S6, S8, and S9 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Section 1: Supplementary Materials and Methods Section 2: Supplementary Tables Supplementary Table S3. Tools and databases used in this study. Supplementary Table S4. Primers used for validating variants. Supplementary Table S6. Putative d…
View article: Data from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Data from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Cancer cell culture has been a backbone in cancer research, in which analysis of human cell line mutational profiles often correlates with oncogene addiction and drug sensitivity. We have conducted whole-exome sequence analyses on 33 canin…
View article: Supplementary Figs. S1 - S6 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Supplementary Figs. S1 - S6 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Supplementary Fig. S1. Pipeline for post-processing of somatic variants. Supplementary Fig. S2. Distribution of genes and variants. Supplementary Fig. S3. MDM2 and TP53 transcript levels. Supplementary Fig. S4. KEGG MAPK pathway. Supplemen…
View article: Data from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Data from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Cancer cell culture has been a backbone in cancer research, in which analysis of human cell line mutational profiles often correlates with oncogene addiction and drug sensitivity. We have conducted whole-exome sequence analyses on 33 canin…
View article: Supplementary Tables S1, S2, S5, and S7 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Supplementary Tables S1, S2, S5, and S7 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Supplementary Table S1A. Metadata associated with canine cancer cell line panel. Supplementary Table S1B. Metadata associated with normal samples. Supplementary Table S2. Certificate of Analysis - Cell Line Validation. Supplementary Table …
View article: Supplementary Figs. S1 - S6 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Supplementary Figs. S1 - S6 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Supplementary Fig. S1. Pipeline for post-processing of somatic variants. Supplementary Fig. S2. Distribution of genes and variants. Supplementary Fig. S3. MDM2 and TP53 transcript levels. Supplementary Fig. S4. KEGG MAPK pathway. Supplemen…
View article: Supplementary Materials and Methods and Supplementary Tables S3, S4, S6, S8, and S9 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Supplementary Materials and Methods and Supplementary Tables S3, S4, S6, S8, and S9 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Section 1: Supplementary Materials and Methods Section 2: Supplementary Tables Supplementary Table S3. Tools and databases used in this study. Supplementary Table S4. Primers used for validating variants. Supplementary Table S6. Putative d…
View article: Supplementary Tables S1, S2, S5, and S7 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Supplementary Tables S1, S2, S5, and S7 from Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Supplementary Table S1A. Metadata associated with canine cancer cell line panel. Supplementary Table S1B. Metadata associated with normal samples. Supplementary Table S2. Certificate of Analysis - Cell Line Validation. Supplementary Table …
View article: Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in<i>TP53, KMT</i>genes and<i>PDGFB</i>fusions
Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in<i>TP53, KMT</i>genes and<i>PDGFB</i>fusions Open
Canine soft tissue sarcomas (STS) are a heterogenous group of malignant tumors arising from mesenchymal cells of soft tissues. This simplified collective of tumors most commonly arise from subcutaneous tissues, are treated similar clinical…
View article: Whole exome sequencing and gene expression analysis of canine osteosarcomas identify mutant TP53 and enriched immune pathways associated with longer survival
Whole exome sequencing and gene expression analysis of canine osteosarcomas identify mutant TP53 and enriched immune pathways associated with longer survival Open
Osteosarcoma affects about 2.8% of dogs with cancer, with a one-year survival rate of approximately 45%. The purpose of this study was to characterize the mutation and expression profiles of canine osteosarcoma associated with outcome in s…
View article: Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing Open
Cancer cell culture has been a backbone in cancer research, in which analysis of human cell line mutational profiles often correlates with oncogene addiction and drug sensitivity. We have conducted whole-exome sequence analyses on 33 canin…
View article: Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis
Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis Open
Telomeres are nucleoprotein complexes comprised of tandem arrays of repetitive DNA sequence that serve to protect chromosomal termini from inappropriate degradation, as well as to prevent these natural DNA ends from being recognized as bro…
View article: NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability Open
NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) is a 27 kD chromosomal, vertebrate-specific protein, for which limited functional data exist. Here, we demonstrate that NUCKS1 shares extensive sequence homology with R…