Rupak Mukherjee
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View article: Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer
Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer Open
SFRP2 localizes to tumor, TAMs and TILs in the tumor microenvironment and is negatively associated INF-ƴ in human tumors. hSFRP2 mAb reduces primary and metastatic TNBC growth, increases INF-ƴ from TAMS, boosts the M1/M2 ratio in lung meta…
View article: Identification of phase correlations in Financial Stock Market Turbulence
Identification of phase correlations in Financial Stock Market Turbulence Open
The basis of arbitrage methods depends on the circulation of information within the framework of the financial market. Following the work of Modigliani and Miller, it has become a vital part of discussions related to the study of financial…
View article: Knot-detection algorithm to measure viscosity in three-dimensional MHD plasmas
Knot-detection algorithm to measure viscosity in three-dimensional MHD plasmas Open
This project explores the mathematical study of knots and links in topology, focusing on differentiating between the two-component Unlink and the Hopf Link using a computational tool named LINKAGE. LINKAGE employs the linking number, calcu…
View article: Reduced dimensional description of hydromagnetic turbulence capturing higher order fluid moments
Reduced dimensional description of hydromagnetic turbulence capturing higher order fluid moments Open
In this paper, Chandrasekhar's deductive theory of turbulence is extended to the case of hydrodynamics and hydromagnetics, with higher order fluid moments. We include the contributions from correlation tensors at two different points of sp…
View article: Benefits of Early Vascular Provider Involvement in Wound Care Center Management of Patients With Underlying Arterial Disease
Benefits of Early Vascular Provider Involvement in Wound Care Center Management of Patients With Underlying Arterial Disease Open
View article: Nonlinear Coupling of Kinetic Alfven Waves and Ion Acoustic Waves in the inner Heliosphere
Nonlinear Coupling of Kinetic Alfven Waves and Ion Acoustic Waves in the inner Heliosphere Open
We study the nonlinear coupling of kinetic Alfv\'{e}n waves with ion acoustic waves applicable to the Earth's radiation belt and near-Sun streamer belt solar wind using dynamical equations in the form of modified Zakharov systems. Numerica…
View article: The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer
The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer Open
View article: Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis
Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis Open
Pancreatic adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year survival rates of 9%. We hypothesized that secreted frizzled-related protein 2 (SFRP2) may influence stromal growth in pancreatic cancer, since it increases f…
View article: Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development
Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development Open
View article: Effect of neutral interactions on parallel transport and blob dynamics in gyrokinetic scrape-off layer simulations
Effect of neutral interactions on parallel transport and blob dynamics in gyrokinetic scrape-off layer simulations Open
The effect of neutral interactions on scrape-off layer (SOL) turbulence is investigated in a continuum gyrokinetic code that has been coupled to a continuum kinetic model of neutral transport. This extends the work of a previous paper [T. …
View article: Volumetric Ultrasound Analysis of the Abdominal Aorta Enhances Strain Assessment in Hypertensive Mice
Volumetric Ultrasound Analysis of the Abdominal Aorta Enhances Strain Assessment in Hypertensive Mice Open
View article: 340 The Effects of PTSD-Dependent Neurogenic Hypertension and Inflammation on Thoracic Aortic Aneurysm Progression
340 The Effects of PTSD-Dependent Neurogenic Hypertension and Inflammation on Thoracic Aortic Aneurysm Progression Open
OBJECTIVES/GOALS: Nearly all thoracic aortic aneurysm patients suffer from hypertension leading to elevated wall tension and abnormal extracellular matrix remodeling. PTSD patients have higher blood pressure both at rest and in response to…
View article: Signaling through the IL-6-STAT3 Pathway Promotes Proteolytically-Active Macrophage Accumulation Necessary for Development of Small AAA
Signaling through the IL-6-STAT3 Pathway Promotes Proteolytically-Active Macrophage Accumulation Necessary for Development of Small AAA Open
Introduction Elevated interleukin-6 (IL-6) plasma levels have been associated with abdominal aortic aneurysm (AAA), but whether this cytokine plays a causative role in the degenerative remodeling or represents an effect from the inflammato…
View article: Overall Survival Differences in Young Black Colorectal Cancer Patients: a Report from the National Cancer Database
Overall Survival Differences in Young Black Colorectal Cancer Patients: a Report from the National Cancer Database Open
Objectives: Black patients have the highest overall incidence rate of early onset colorectal cancer, with many of these patients presenting with more aggressive disease at diagnosis, ultimately leading to decreased overall survival.…
View article: Electromagnetic pinned solitons for space debris detection
Electromagnetic pinned solitons for space debris detection Open
Electromagnetic “pinned” solitons in the form of stationary nonlinear waves are studied within the framework of an inertial magneto-hydrodynamic model. These structures, that can arise when a charged source moves in a magnetized plasma, ha…
View article: The Impact of Nurse Navigation on Timeliness to Treatment for Benign High-Risk Breast Pathology
The Impact of Nurse Navigation on Timeliness to Treatment for Benign High-Risk Breast Pathology Open
Purpose High-risk breast pathology is a breast cancer risk factor for which timely treatment is crucial. Nurse navigation programs have been implemented to minimize delays in patient care. This study evaluated nurse navigation in terms of …
View article: Cellular and Molecular Mechanisms of MEK1 Inhibitor–Induced Cardiotoxicity
Cellular and Molecular Mechanisms of MEK1 Inhibitor–Induced Cardiotoxicity Open
These data describe pathologic changes observed in trametinib cardiotoxicity, supporting the exploration of drug holidays and alternative pharmacologic strategies for disease prevention.
View article: PSAT378 Hashimoto's Thyroiditis and Differentiated Thyroid Cancer Aggressiveness
PSAT378 Hashimoto's Thyroiditis and Differentiated Thyroid Cancer Aggressiveness Open
Background Hashimoto's thyroiditis (HT) is associated with a 1.5-fold increased risk of differentiated thyroid cancer (DTC). It is postulated that the inflammatory milieu in HT may damage thyrocytes, increasing the risk of cancer. However,…
View article: The Anti-Proliferative Effects of a Frankincense Extract in a Window of Opportunity Phase Ia Clinical Trial for Patients with Breast Cancer
The Anti-Proliferative Effects of a Frankincense Extract in a Window of Opportunity Phase Ia Clinical Trial for Patients with Breast Cancer Open
Background Boswellic acids, the active components of frankincense, have been shown to suppress tumor proliferation and apoptosis in vitro with a strong clinical trial safety profile in patients with inflammatory diseases. We performed a Ph…
View article: Understanding the surface wave characteristics using 2D particle-in-cell simulation and deep neural network
Understanding the surface wave characteristics using 2D particle-in-cell simulation and deep neural network Open
The characteristics of the surface waves along the interface between a plasma and a dielectric material have been investigated using kinetic particle-in-cell simulations. A microwave source of GHz frequency has been used to trigger the sur…
View article: Vascular Smooth Muscle Cell Mechanotransduction through Serum and Glucocorticoid Inducible Kinase -1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension
Vascular Smooth Muscle Cell Mechanotransduction through Serum and Glucocorticoid Inducible Kinase -1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension Open
View article: The Perioperative Patient Experience During COVID-19
The Perioperative Patient Experience During COVID-19 Open
Background Access to elective surgical procedures has been impacted by the COVID-19 pandemic. Methods We sought to understand the patient experience by developing and distributing an anonymous online survey to those who underwent non-emerg…
View article: Understanding the surface wave characteristics using 2D particle-in-cell simulation and deep neural network
Understanding the surface wave characteristics using 2D particle-in-cell simulation and deep neural network Open
The characteristics of the surface waves along the interface between a plasma and a dielectric material have been investigated using kinetic Particle-In-Cell (PIC) simulations. A microwave source of GHz frequency has been used to trigger t…
View article: Virtual Visits for Outpatient Burn Care During the COVID-19 Pandemic
Virtual Visits for Outpatient Burn Care During the COVID-19 Pandemic Open
Burn-injured patients must frequently travel long distances to regional burn centers, creating a burden on families and impairing clinical outcomes. Recent federal policies in response to the coronavirus pandemic have relaxed major barrier…
View article: Staged Endovascular Repair of Thoracoabdominal Aortic Aneurysms Does Not Confer Protection Against Spinal Cord Ischemia
Staged Endovascular Repair of Thoracoabdominal Aortic Aneurysms Does Not Confer Protection Against Spinal Cord Ischemia Open
View article: Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma Open
Secreted frizzled-related protein 2 (SFRP2) promotes the migration/invasion of metastatic osteosarcoma (OS) cells and tube formation by endothelial cells. However, its function on T-cells is unknown. We hypothesized that blocking SFRP2 wit…
View article: Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation
Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation Open
Hypertension (HTN) and abdominal aortic aneurysm (AAA) have been epidemiologically linked for decades; however, a biomechanical link has not yet been identified. Using a murine model of spontaneous neurogenic HTN experimentally demonstrate…
View article: The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice
The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice Open
TNNI3K expression worsens disease progression in several mouse heart pathology models. TNNI3K expression also reduces the number of diploid cardiomyocytes, which may be detrimental to adult heart regeneration. However, the gene is evolutio…
View article: Commentary: We don't need no postop AF… All in all it's just another (β)-block in the wall
Commentary: We don't need no postop AF… All in all it's just another (β)-block in the wall Open
View article: MON-532 Characterization of the Angiogenic Factor SFRP2 in Papillary Thyroid Carcinoma
MON-532 Characterization of the Angiogenic Factor SFRP2 in Papillary Thyroid Carcinoma Open
Over the last decade, there has been an average annual increase of 3.1% in thyroid cancer diagnosis in the U.S. Papillary thyroid carcinoma (PTC) accounts for 80% of all thyroid cancer diagnoses. However, few molecular markers exist to ide…