Rupak Pathak
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View article: Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link
Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link Open
The gut microbiota play a crucial role in cancer pathogenesis, partly through metabolites derived from dietary components or host compounds. Among these, trimethylamine N-oxide (TMAO), a secondary gut microbiota-derived metabolite has gain…
View article: Musculoskeletal miRNA profiling after exposure to simulated space stressors in mice
Musculoskeletal miRNA profiling after exposure to simulated space stressors in mice Open
Prolonged spaceflight exposes astronauts to chronic irradiation and microgravity, inducing oxidative stress through the production of reactive oxygen species (ROS). This study identified two microRNAs, Mir6236 and Mir6240, that were signif…
View article: Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation
Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation Open
Given NASA's plans for manned lunar and Mars missions, it is critical to assess the risk of splenic immune dysregulation by using ground-based models of simulated microgravity (SMG) and/or chronic irradiation (CIR). To address this, C57BL/…
View article: Effectiveness of Homoeopathic Medicines in Treatment of Osteoporosis in Post Menopausal Age- A Case Report
Effectiveness of Homoeopathic Medicines in Treatment of Osteoporosis in Post Menopausal Age- A Case Report Open
Background: Osteoporosis is a common condition in postmenopausal women due to oestrogen deficiency, leading to decreased bone density and increased fracture risk. Conventional treatment often involves hormone replacement therapy and calciu…
View article: Exploring the Scope of Homeopathy in Addressing Vaccine Hesitancy in HPV and Cervical Cancer Prevention
Exploring the Scope of Homeopathy in Addressing Vaccine Hesitancy in HPV and Cervical Cancer Prevention Open
Human papillomavirus (HPV) infection remains a significant global health concern, particularly due to its association with cervical cancer, the fourth most common cancer among women worldwide. This article explores the molecular mechanisms…
View article: Hepatoprotective effects of Carduus marianus (Silymarin): A systematic analysis of evidence from traditional and modern medicine
Hepatoprotective effects of Carduus marianus (Silymarin): A systematic analysis of evidence from traditional and modern medicine Open
View article: Homeopathy for hypothyroidism: Reviewing the evidence from clinical studies and trials
Homeopathy for hypothyroidism: Reviewing the evidence from clinical studies and trials Open
View article: 591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice
591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice Open
Objectives/Goals: Radiation nephropathy results in morbidity and mortality in patients receiving cancer treatment. In addition, low birth weight and low nephron number are associated with increased risk for chronic kidney disease. This stu…
View article: Understanding tonsilloliths and their treatment through homoeopathy: An integrative review
Understanding tonsilloliths and their treatment through homoeopathy: An integrative review Open
View article: Therapeutic potential of homoeopathic remedy Calcarea picrica in acne vulgaris: A clinical case report
Therapeutic potential of homoeopathic remedy Calcarea picrica in acne vulgaris: A clinical case report Open
View article: Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage
Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage Open
Highly conformal delivery of radiation therapy (RT) has revolutionized the treatment landscape for primary and metastatic liver cancers, yet concerns persist regarding radiation-induced liver disease (RILD). Despite advancements, RILD rema…
View article: G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells
G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells Open
Endothelial cells (ECs) maintain vessel tone and barrier integrity, regulate blood homeostasis, and prevent the extravasation of leukocytes under normal physiological conditions. Because of the limited lifespans and batch-to-batch differen…
View article: Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals
Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals Open
View article: 564 Platelets and Leukocytes Interact to Modulate Inflammation in Patients with CKD
564 Platelets and Leukocytes Interact to Modulate Inflammation in Patients with CKD Open
OBJECTIVES/GOALS: Platelets interact with leukocytes in the circulation to modulate inflammation in chronic diseases. In previous clinical study, we showed that platelet leukocyte interaction is reduced in the circulation of patients with …
View article: Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review
Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review Open
Rectal cancer accounts for the second highest cancer-related mortality, which is predominant in Western civilizations. The treatment for rectal cancers includes surgery, radiotherapy, chemotherapy, and immunotherapy. Radiotherapy, specific…
View article: Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis
Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis Open
The study of chromosomes without or with molecular DNA probes provides crucial insight for understanding research findings, as well as refining diagnosis, prognosis, and therapeutics in clinical settings. Here, we present a protocol for ch…
View article: Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects Open
Tocotrienols have powerful radioprotective properties in multiple organ systems and are promising candidates for development as clinically effective radiation countermeasures. To facilitate their development as clinical radiation counterme…
View article: Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance
Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance Open
Space exploration has advanced substantially over recent decades and plans to increase the duration of deep space missions are in preparation. One of the primary health concerns is potential damage to the central nervous system (CNS), resu…
View article: Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile
Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile Open
Radiation-induced toxicity to healthy/normal intestinal tissues, especially during radiotherapy, limits the radiation dose necessary to effectively eradicate tumors of the abdomen and pelvis. Although the pathogenesis of intestinal radiati…
View article: Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese Open
The results of this study provide first evidence of the presence of stable genetic and epigenetic rearrangements in peripheral lymphocytes of NWA Marshallese and warrant further studies to analyze the role of radiation exposure in health d…
View article: Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells
Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells Open
Primary human umbilical vein endothelial cells (HUVECs) are consistently the most reliable in vitro model system for studying the inner lining of blood and lymphatic vessels or the endothelium. Primary human cells originate from freshly is…
View article: Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice Open
The damaging effects of ionizing radiation (IR) on bone mass are well-documented in mice and humans and are most likely due to increased osteoclast number and function. However, the mechanisms leading to inappropriate increases in osteocla…
View article: Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
Methods for induction and assessment of intestinal permeability in rodent models of radiation injury Open
View article: Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese Open
Nuclear weapons testing in the northern Marshall Islands between 1946 and 1958 resulted in ionizing radiation (IR) exposure of the thousands of Marshallese. Furthermore, numerous islands were contaminated by radioactive fallout. Significan…
View article: Platelet glycoprotein Ibα provides radiation protection
Platelet glycoprotein Ibα provides radiation protection Open
View article: Synthetic Matrices for Intestinal Organoid Culture: Implications for Better Performance
Synthetic Matrices for Intestinal Organoid Culture: Implications for Better Performance Open
Organoids are three-dimensional (3D) self-renewing and self-organizing clusters of cells that imitate an organ's structure and function, making them an important tool in various fields ranging from regenerative medicine to drug discovery. …
View article: Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure Open
The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways involved in radiation-induced GI injury, this study assessed dose- and time-dependen…
View article: Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model Open
View article: Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates
Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates Open
In the event of a radiological attack or accident, it is more likely that the absorbed radiation dose will be heterogeneous, rather than uniformly distributed throughout the body. This type of uneven dose distribution is known as partial-b…
View article: Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells Open
Both cell and animal studies have shown that complete or partial deficiency of methionine inhibits tumor growth. Consequently, the potential implementation of this nutritional intervention has recently been of great interest for the treatm…