Rupal K Jaffa
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View article: Effectiveness of imipenem-relebactam for multidrug-resistant <i>Pseudomonas aeruginosa</i> in pneumonia and bloodstream infections in the United States (MIRAGE)
Effectiveness of imipenem-relebactam for multidrug-resistant <i>Pseudomonas aeruginosa</i> in pneumonia and bloodstream infections in the United States (MIRAGE) Open
Imipenem-relebactam demonstrates in vitro activity against multidrug-resistant (MDR) Pseudomonas aeruginosa , but real-world effectiveness data are limited. MIRAGE was a multicenter, retrospective, observational study of imipenem-relebacta…
View article: P-1409. Differential Impact of a Penicillin Allergy Assessment Tool on Orthopedic Surgical Patients from Areas of High Social Vulnerability
P-1409. Differential Impact of a Penicillin Allergy Assessment Tool on Orthopedic Surgical Patients from Areas of High Social Vulnerability Open
Background Penicillin allergy labels (PAL) have been associated with increased risk of surgical site infections. Many penicillin allergy assessment tools are being trialed to improve perioperative β-lactam utilization. We report on the soc…
View article: P-387. Exploring the Association Between Penicillin Allergy Labels (PAL), β-Lactam Utilization and Surgical Site Infections
P-387. Exploring the Association Between Penicillin Allergy Labels (PAL), β-Lactam Utilization and Surgical Site Infections Open
Background Several studies have reported higher surgical site infection (SSI) risk in patients with a penicillin allergy label (PAL). We explore the association between PAL, receipt of β Lactam Antibiotics and SSI in patients undergoing hi…
View article: 322. Improving Assessment of Beta-Lactam Allergies by Embedding a Questionnaire in Best Practice Advisory Alerts Across a Large Health System
322. Improving Assessment of Beta-Lactam Allergies by Embedding a Questionnaire in Best Practice Advisory Alerts Across a Large Health System Open
Background Penicillin (PCN) allergy is commonly reported. Yet most patients labeled allergic can tolerate beta-lactams (BLs), the antibiotics of choice for many infections. Documentation of reaction details is important to identify low ris…
View article: 248. Evaluation of Continuous versus Intermittent Infusion of Nafcillin in the Treatment of Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia
248. Evaluation of Continuous versus Intermittent Infusion of Nafcillin in the Treatment of Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia Open
Background Anti-Staphylococcal penicillins (ASPCN) are first-line agents in the treatment of methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B), and continuous infusion (CI) of oxacillin was associated with higher rates of 3…
View article: 1322. Outcomes Associated with Primary Antibiotic Therapy in Spinal Epidural Abscess due to <i>Staphylococcus aureus: C</i>omparison of First-line vs Alternative Agents
1322. Outcomes Associated with Primary Antibiotic Therapy in Spinal Epidural Abscess due to <i>Staphylococcus aureus: C</i>omparison of First-line vs Alternative Agents Open
Background Spinal epidural abscess (SEA) is an uncommon but serious infection with potentially devastating sequelae. For SEA due to methicillin- susceptible S. aureus (MSSA), anti-Staphylococcal penicillins have been considered first line,…
View article: 1127. Validation of an Adult and Pediatric Beta-Lactam Allergy Risk Stratification Tool
1127. Validation of an Adult and Pediatric Beta-Lactam Allergy Risk Stratification Tool Open
Background Penicillin allergies are commonly reported, yet more than 95% of these patients can tolerate β-lactams. A comprehensive allergy history is essential when determining which patients can safely receive a β-lactam but is rarely obt…
View article: 134. Impact of an Antibiotic Stewardship Treatment and Management Algorithm for Liver Abscesses
134. Impact of an Antibiotic Stewardship Treatment and Management Algorithm for Liver Abscesses Open
Background Antibiotic prescribing for pyogenic liver abscess(es) (PLA) is highly variable with literature primarily aimed at assessing surgical intervention with a scarcity of data for antibiotic selection and duration of therapy. Given th…
View article: Implementation of a comprehensive intervention focused on hospitalized patients with HIV by an existing stewardship program: successes and lessons learned
Implementation of a comprehensive intervention focused on hospitalized patients with HIV by an existing stewardship program: successes and lessons learned Open
Background: Several national organizations have advocated for inpatient antiretroviral stewardship to prevent the consequences of medication-related errors. This study aimed to evaluate the impact of a stewardship initiative on outcomes in…
View article: 197. Bridging the Divide Between Antimicrobial Stewardship and Surgical Services: Successful Use of Handshake Stewardship with Hepato-Pancreato-Biliary Surgical Services in Adult Patients at a Large Academic Medical Center
197. Bridging the Divide Between Antimicrobial Stewardship and Surgical Services: Successful Use of Handshake Stewardship with Hepato-Pancreato-Biliary Surgical Services in Adult Patients at a Large Academic Medical Center Open
Background Handshake stewardship has displayed promise in engaging providers in the pediatric population but literature in adults are lacking. Face-to-face interactions are proposed to improve antibiotic stewardship (ASP) efforts in challe…
View article: 239. Outcomes Associated with Empiric Aztreonam Use Compared to Anti-Pseudomonal β-lactams in Patients with Sepsis: An Opportunity for Allergy Stewardship
239. Outcomes Associated with Empiric Aztreonam Use Compared to Anti-Pseudomonal β-lactams in Patients with Sepsis: An Opportunity for Allergy Stewardship Open
Background Aztreonam is often given to patients with a documented β-lactam allergy in lieu of a first-line anti-pseudomonal β-lactam (APBL). However, aztreonam offers no gram positive coverage and data suggest that gram negative organisms …
View article: 2117. Fluconazole vs. Echinocandins as Initial Therapy for Candidemia Caused by Fluconazole-Susceptible Species in the Era of Rapid Diagnostic Testing
2117. Fluconazole vs. Echinocandins as Initial Therapy for Candidemia Caused by Fluconazole-Susceptible Species in the Era of Rapid Diagnostic Testing Open
Background Echinocandins (ECH) are recommended first-line for initial therapy (IT) of candidemia (CD) over fluconazole (FLU) due to their broad spectrum of activity. This recommendation was made prior to widespread implementation of rapid …
View article: 1085. Impact of a Novel Infectious Diseases Pharmacy Service on Medication-Related Errors and Linkage to Care in Inpatients Living with Human Immunodeficiency Virus
1085. Impact of a Novel Infectious Diseases Pharmacy Service on Medication-Related Errors and Linkage to Care in Inpatients Living with Human Immunodeficiency Virus Open
Background Complexity of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) and lack of experience with treatment regimens by providers may lead to medication-related errors (MRE). Consequences of MRE may include loss of v…
View article: Effect of a multifaceted stewardship intervention on antibiotic prescribing and outcomes for acute bacterial skin and skin structure infections
Effect of a multifaceted stewardship intervention on antibiotic prescribing and outcomes for acute bacterial skin and skin structure infections Open
Background: Acute bacterial skin and skin structure infections (ABSSSI) are a leading cause of hospitalization, but are often treated inappropriately in the inpatient setting. A multifaceted stewardship intervention was implemented to enco…
View article: Effect of a Multifaceted Stewardship Intervention on Antibiotic Prescribing and Outcomes for Acute Bacterial Skin and Skin Structure Infections
Effect of a Multifaceted Stewardship Intervention on Antibiotic Prescribing and Outcomes for Acute Bacterial Skin and Skin Structure Infections Open
Acute bacterial skin and skin structure infections (ABSSSI) are a leading cause of hospitalization; however, ABSSSI are often treated inappropriately in the inpatient setting. A multifaceted stewardship intervention was implemented at a la…