Rupert Major
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View article: Implementing a model of integrated CKD management between primary and secondary care
Implementing a model of integrated CKD management between primary and secondary care Open
Chronic kidney disease (CKD) is a common condition and important cardiovascular risk factor. However, CKD remains underdiagnosed and evidence-based medicines underutilized. In most healthcare systems, most CKD is managed in primary care. O…
View article: Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk
Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk Open
National Kidney Foundation and National Institute of Diabetes and Digestive and Kidney Diseases.
View article: Kidney failure risk equation to predict kidney transplant failure in individuals with an eGFR<30 mL/min/1.73 m <sup>2</sup> : a UK Renal Registry external validation and recalibration study
Kidney failure risk equation to predict kidney transplant failure in individuals with an eGFR2</sup> : a UK Renal Registry external validation and recalibration study Open
Objectives To externally validate and subsequently repurpose/recalibrate the easily accessible kidney failure risk equation (KFRE) for a prevalent transplant population with an estimated glomerular filtration rate (eGFR)<30 mL/min/1.73 m².…
View article: Challenges in the clinical use of digital tools in healthcare: barriers and blueprint for Kidney Failure Risk Equation implementation (Preprint)
Challenges in the clinical use of digital tools in healthcare: barriers and blueprint for Kidney Failure Risk Equation implementation (Preprint) Open
BACKGROUND Chronic kidney disease (CKD) affects approximately 10% of the global population and is a major contributor to morbidity and the need for kidney replacement therapy. The Kidney Failure Risk Equation (KFRE) is a validated risk pr…
View article: Integrated primary and secondary care optimizes the management of people with CKD—the LUCID project
Integrated primary and secondary care optimizes the management of people with CKD—the LUCID project Open
Background Early diagnosis, risk stratification and medication optimization are essential to improve the management of chronic kidney disease (CKD) and other long-term conditions. The introduction of Integrated Care Systems (ICS) in Englan…
View article: Understanding the failings of yesterday to improve the outcomes of tomorrow: a CardioRenal story
Understanding the failings of yesterday to improve the outcomes of tomorrow: a CardioRenal story Open
"In spite of the accumulating evidence of their efficacy, established treatments for maintaining renal function remain woefully underutilized. Clinicians and health care systems must be encouraged to make use of these treatments."1.
View article: Using the kidney failure risk equation to predict end-stage kidney disease in CKD patients of South Asian ethnicity: an external validation study
Using the kidney failure risk equation to predict end-stage kidney disease in CKD patients of South Asian ethnicity: an external validation study Open
Background The kidney failure risk equation (KFRE) predicts the 2- and 5-year risk of needing kidney replacement therapy (KRT) using four risk factors — age, sex, urine albumin-to-creatinine ratio (ACR) and creatinine-based estimated glome…
View article: #5522 USING THE KIDNEY FAILURE RISK EQUATION TO PREDICT END-STAGE KIDNEY DISEASE IN CKD PATIENTS OF SOUTH ASIAN ETHNICITY: AN EXTERNAL VALIDATION STUDY
#5522 USING THE KIDNEY FAILURE RISK EQUATION TO PREDICT END-STAGE KIDNEY DISEASE IN CKD PATIENTS OF SOUTH ASIAN ETHNICITY: AN EXTERNAL VALIDATION STUDY Open
Background and Aims The Kidney Failure Risk Equation (KFRE) predicts the 2- and 5-year risk of needing kidney replacement therapy (KRT) using four risk factors – age, sex, urine albumin-to-creatinine ratio (ACR), and creatinine-based estim…
View article: Using the Kidney Failure Risk Equation to predict end-stage kidney disease in CKD patients of South Asian ethnicity: an external validation study
Using the Kidney Failure Risk Equation to predict end-stage kidney disease in CKD patients of South Asian ethnicity: an external validation study Open
Background: The Kidney Failure Risk Equation (KFRE) predicts the 2- and 5-year risk of needing kidney replacement therapy (KRT) using four risk factors – age, sex, urine albumin-to-creatinine ratio (ACR), and creatinine-based estimated glo…
View article: The Kidney Failure Risk Equation: Evaluation of Novel Input Variables including eGFR Estimated Using the CKD-EPI 2021 Equation in 59 Cohorts
The Kidney Failure Risk Equation: Evaluation of Novel Input Variables including eGFR Estimated Using the CKD-EPI 2021 Equation in 59 Cohorts Open
Significance Statement The kidney failure risk equation (KFRE) uses age, sex, GFR, and urine albumin-to-creatinine ratio (ACR) to predict 2- and 5-year risk of kidney failure in populations with eGFR <60 ml/min per 1.73 m 2 . However, the …
View article: Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a CKD Prognosis Consortium study
Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a CKD Prognosis Consortium study Open
Aims Chronic kidney disease (CKD) increases risk of cardiovascular disease (CVD). Less is known about how CVD associates with future risk of kidney failure with replacement therapy (KFRT). Methods and results The study included 25 903 761 …
View article: Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study
Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study Open
Background National Institute for Health and Care Excellence 2021 guidelines on chronic kidney disease (CKD) recommend the use of the Kidney Failure Risk Equation (KFRE), which includes measurement of albuminuria. The equation to calculate…
View article: Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP
Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP Open
Aims The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age…
View article: Development and validation of prediction models of adverse kidney outcomes in the population with and without diabetes mellitus
Development and validation of prediction models of adverse kidney outcomes in the population with and without diabetes mellitus Open
Objective: To predict adverse kidney outcomes for use in optimizing medical management and clinical trial design. Research Design and Methods: In this individual participant data meta-analysis, 43 cohorts (N=1,621,817) from research stud…
View article: Development and validation of prediction models of adverse kidney outcomes in the population with and without diabetes mellitus
Development and validation of prediction models of adverse kidney outcomes in the population with and without diabetes mellitus Open
Objective: To predict adverse kidney outcomes for use in optimizing medical management and clinical trial design. Research Design and Methods: In this individual participant data meta-analysis, 43 cohorts (N=1,621,817) from research stud…
View article: Development and Validation of Prediction Models of Adverse Kidney Outcomes in the Population With and Without Diabetes
Development and Validation of Prediction Models of Adverse Kidney Outcomes in the Population With and Without Diabetes Open
OBJECTIVE To predict adverse kidney outcomes for use in optimizing medical management and clinical trial design. RESEARCH DESIGN AND METHODS In this meta-analysis of individual participant data, 43 cohorts (N = 1,621,817) from research stu…
View article: Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis
Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis Open
Objective To externally validate various prognostic models and scoring rules for predicting short term mortality in patients admitted to hospital for covid-19. Design Two stage individual participant data meta-analysis. Setting Secondary a…
View article: Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK
Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK Open
Objectives To assess the applicability of risk factors for severe COVID-19 defined in the general population for patients on haemodialysis. Setting A retrospective cross-sectional study performed across thirty four haemodialysis units in m…
View article: Cardiovascular Risk Models in Chronic Kidney Disease: A Systematic Review and External Validation of Models
Cardiovascular Risk Models in Chronic Kidney Disease: A Systematic Review and External Validation of Models Open
Background and Objectives Risk factors for cardiovascular disease in chronic kidney disease differ to the general population due to the increased role of inflammation, calcification and arteriosclerosis. Over 350 cardiovascular risk models…
View article: Primary skeletal muscle cells from chronic kidney disease patients retain hallmarks of cachexia <i>in vitro</i>
Primary skeletal muscle cells from chronic kidney disease patients retain hallmarks of cachexia <i>in vitro</i> Open
Background Skeletal muscle wasting and dysfunction are common characteristics noted in people who suffer from chronic kidney disease (CKD). The mechanisms by which this occurs are complex, and although progress has been made, the key under…
View article: Aspirin for the primary prevention of cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis
Aspirin for the primary prevention of cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis Open
Aims Cardiovascular disease (CVD) is the major cause of morbidity and mortality in individuals with chronic kidney disease (CKD). This study assessed the risks and benefits of aspirin in the primary prevention of CVD in individuals with CK…
View article: Risk-Based Triage for Nephrology Referrals: The Time is Now
Risk-Based Triage for Nephrology Referrals: The Time is Now Open
See Clinical Research on Page 2189 See Clinical Research on Page 2189 Chronic kidney disease (CKD) is common, but progression to kidney failure requiring dialysis or kidney transplantation remains an uncommon event in patients with CKD.1Be…
View article: Paying kidney donors: time to follow Iran?
Paying kidney donors: time to follow Iran? Open
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View article: Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis
Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis Open
Evidence is growing for a role of vitamin D in regulating skeletal muscle mass, strength and functional capacity. Given the role the kidneys play in activating total vitamin D, and the high prevalence of vitamin D deficiency in Chronic Kid…
View article: Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets
Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets Open
US National Kidney Foundation and the NIDDK.
View article: The Exclusion of Patients with CKD in Prospectively Registered Interventional Trials for COVID-19—a Rapid Review of International Registry Data
The Exclusion of Patients with CKD in Prospectively Registered Interventional Trials for COVID-19—a Rapid Review of International Registry Data Open
The exclusion of patients with CKD from clinical trials has been a barrier to therapeutic advancement in CKD for the last two decades.1 These inequities were highlighted by the Kidney Disease Improving Global Outcomes Controversies Confere…
View article: The association of muscle size, strength and exercise capacity with all‐cause mortality in non‐dialysis‐dependent CKD patients
The association of muscle size, strength and exercise capacity with all‐cause mortality in non‐dialysis‐dependent CKD patients Open
Background/Objective Patients with chronic kidney disease (CKD) are commonly reported to exhibit skeletal muscle wasting, reduced strength and exercise capacity. Evidence from patients with end‐stage renal disease (ESRD) demonstrates these…
View article: Correction: The Kidney Failure Risk Equation for prediction of end stage renal disease in UK primary care: An external validation and clinical impact projection cohort study
Correction: The Kidney Failure Risk Equation for prediction of end stage renal disease in UK primary care: An external validation and clinical impact projection cohort study Open
[This corrects the article DOI: 10.1371/journal.pmed.1002955.].