Ruple S. Laughlin
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View article: Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis
Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis Open
Nerve conduction F-wave studies contain crucial information about subclinical motor dysfunction that can be used to diagnose patients with amyotrophic lateral sclerosis (ALS). However, F-wave responses are highly variable in morphology, ma…
View article: Author Correction: Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial
Author Correction: Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial Open
of the Results, which incorrectly read 'The average duration between injury and AD-MSC injection was 11 months (range of 8-22)'.The correct version replaces this sentence with 'The average duration between injury and AD-MSC injection was 1…
View article: Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial
Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial Open
Intrathecal delivery of autologous culture-expanded adipose tissue-derived mesenchymal stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I trial (ClinicalTrials.gov: NCT03308565) included 10 pati…
View article: The utility of electrodiagnostic testing in unprovoked rhabdomyolysis in the era of next‐generation sequencing
The utility of electrodiagnostic testing in unprovoked rhabdomyolysis in the era of next‐generation sequencing Open
Introduction/Aims Rhabdomyolysis is an etiologically heterogeneous, acute necrosis of myofibers characterized by transient marked creatine kinase (CK) elevation associated with myalgia, muscle edema, and/or weakness. The study aimed to det…
View article: The Neuromuscular Portal and Match
The Neuromuscular Portal and Match Open
Prior to 2021, the neuromuscular medicine fellowship application process suffered from non-standardized timelines and substantial variability. To rectify this, the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) …
View article: Estimating Intraoperative Neurophysiological Monitoring Rates for Anterior Cervical Discectomy and Fusion: Are Diagnostic or Procedural Codes Accurate?
Estimating Intraoperative Neurophysiological Monitoring Rates for Anterior Cervical Discectomy and Fusion: Are Diagnostic or Procedural Codes Accurate? Open
Currently available national databases based on administrative codes do not accurately reflect IONM usage.
View article: Electrodiagnostic Characteristics Suggestive of Muscle-Specific Kinase Myasthenia Gravis
Electrodiagnostic Characteristics Suggestive of Muscle-Specific Kinase Myasthenia Gravis Open
Patients with MuSK + MG may have a recognizable EDX profile from AchR + MG that includes (1) myotonic discharges, (2) greater occurrence of myopathic appearing MUPs in clinically mild disease, and (3) symptoms leading to earlier testing.
View article: The neuromuscular fellowship portal and match
The neuromuscular fellowship portal and match Open
For many years, Neuromuscular Medicine programs lacked a standardized means of handling fellowship applications and offering positions. Programs interviewed applicants and made offers as early as the first half of Post Graduate Year 3 (PGY…
View article: Risk factors for lumbosacral radiculoplexus neuropathy
Risk factors for lumbosacral radiculoplexus neuropathy Open
Introduction/Aims Recently, our group found an association between diabetes mellitus (DM) and lumbosacral radiculoplexus neuropathy (LRPN) in Olmsted County, Minnesota; we found a higher risk (odds ratio [OR], 7.91) for developing LRPN in …
View article: Lumbosacral Radiculoplexus Neuropathy
Lumbosacral Radiculoplexus Neuropathy Open
LRPN is a painful, paralytic, asymmetric, monophasic, sometimes bilateral pan-plexopathy that improves over time but leaves patients with impairment. Although having LRPN increases mortality, this increase is probably due to comorbidities …
View article: Diagnostic modelling and therapeutic monitoring of immune-mediated necrotizing myopathy: role of electrical myotonia
Diagnostic modelling and therapeutic monitoring of immune-mediated necrotizing myopathy: role of electrical myotonia Open
Delayed diagnosis of immune-mediated necrotizing myopathy leads to increased morbidity. Patients with the chronic course without 3-hydroxy-3-methylglutaryl-coenzyme-A reductase-IgG or signal recognition particle-IgG are often challenging t…
View article: Congenital myopathies in the adult neuromuscular clinic
Congenital myopathies in the adult neuromuscular clinic Open
CMs in adulthood represent a diagnostic challenge, as they may lack the clinical and myopathologic features classically associated with CM. Our findings underscore the need for a revision of the terminology and current classification of th…
View article: Teaching Video NeuroImages: Foix-Chavany-Marie syndrome
Teaching Video NeuroImages: Foix-Chavany-Marie syndrome Open
A 75-year-old woman with a history of multiple resolved hemiparetic strokes presented with unilateral ischemic stroke causing sudden loss of volitional control of the musculature crucial for speaking and swallowing. Automatic movements, su…
View article: Clinical spectrum of neuropathy after primary total knee arthroplasty: A series of 54 cases
Clinical spectrum of neuropathy after primary total knee arthroplasty: A series of 54 cases Open
Introduction Neuropathy after total knee arthroplasty (TKA) can cause significant morbidity but is inconsistently reported. Methods We reviewed the clinical, electrodiagnostic and perioperative features of all patients who underwent primar…
View article: Lumbosacral radiculoplexus neuropathy
Lumbosacral radiculoplexus neuropathy Open
LRPN incidence in Olmsted County of 4.16/100,000/y makes LRPN a common inflammatory neuropathy and is higher than that of other immune-mediated neuropathies (acute or chronic inflammatory demyelinating polyradiculoneuropathy, brachial plex…
View article: <i>RYR1</i> causing distal myopathy
<i>RYR1</i> causing distal myopathy Open
Background Congenital myopathies due to ryanodine receptor ( RYR 1 ) mutations are increasingly identified and correlate with a wide range of phenotypes, most commonly that of malignant hyperthermia susceptibility and central cores on musc…
View article: Asymptomatic CNS demyelination related to TNF-α inhibitor therapy
Asymptomatic CNS demyelination related to TNF-α inhibitor therapy Open
Tumor necrosis factor (TNF)–α inhibitors are a subtype of disease-modifying antirheumatic drugs that have revolutionized the treatment of rheumatologic and gastrointestinal disorders. TNF-α is a cytokine with a complex role in immune syste…