Rupsha Fraser
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View article: A novel vaccination strategy induces vaccine-specific mucosal responses at port of viral entry and exit: using systemic SARS-CoV-2 vaccination as a test case
A novel vaccination strategy induces vaccine-specific mucosal responses at port of viral entry and exit: using systemic SARS-CoV-2 vaccination as a test case Open
Respiratory infectious diseases are associated with substantial morbidity and mortality rates worldwide, especially at the extremes of age and in immunocompromised individuals. Over the past two decades, respiratory viruses have driven nin…
View article: Severe COVID-19<i>versus</i>multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection
Severe COVID-19<i>versus</i>multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe…
View article: Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines Open
View article: Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Implications for Female Reproductive Health
Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Implications for Female Reproductive Health Open
Natural killer (NK) cells are the predominant maternal uterine immune cell component, and they densely populate uterine mucosa to promote key changes in the post-ovulatory endometrium and in early pregnancy. It is broadly accepted that (a)…
View article: Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open
View article: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open
View article: A 3D endometrial organotypic model simulating the acute inflammatory decidualisation initiation phase with epithelial induction of the key endometrial receptivity marker, integrin αVβ3
A 3D endometrial organotypic model simulating the acute inflammatory decidualisation initiation phase with epithelial induction of the key endometrial receptivity marker, integrin αVβ3 Open
STUDY QUESTION Is it possible to develop a simplified physiological in vitro system representing the key cell-types associated with a receptive endometrial phenotype? SUMMARY ANSWER We present a new concept to investigate endometrial recep…
View article: COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms
COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms Open
We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the dis…
View article: Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go! Open
Gametogenesis (spermatogenesis and oogenesis) is accompanied by the acquisition of gender-specific epigenetic marks, such as DNA methylation, histone modifications and regulation by small RNAs, to form highly differentiated, but transcript…