Ruslan Deviatiiarov
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View article: Morphological and Transcriptomic Analyses of the Adrenal Gland in Acomys cahirinus: A Novel Model for Murine Adrenal Physiology
Morphological and Transcriptomic Analyses of the Adrenal Gland in Acomys cahirinus: A Novel Model for Murine Adrenal Physiology Open
This study investigates the adrenal gland structure and gene expression in Acomys cahirinus compared to Mus musculus, aiming to assess its relevance for human adrenal disease modeling. We identified a well-defined zona reticularis in Acomy…
View article: The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes Open
Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear β-catenin. Yet, little is known about how β-catenin generates context-specific transcriptional ou…
View article: Molecular insights into human soleus muscle atrophy development: long-term dry immersion effects on the transcriptomic profile and posttranslational signaling
Molecular insights into human soleus muscle atrophy development: long-term dry immersion effects on the transcriptomic profile and posttranslational signaling Open
The main findings of our study are as follows: 1) The soleus slow fibers atrophy after 21-day dry immersion (DI) does not exceed that after 7-day DI; 2) The soleus ubiquitin ligases expression after 21-day DI returns to its initial level; …
View article: Comparative evaluation of ACetic - MEthanol high salt dissociation approach for single-cell transcriptomics of frozen human tissues
Comparative evaluation of ACetic - MEthanol high salt dissociation approach for single-cell transcriptomics of frozen human tissues Open
Current dissociation methods for solid tissues in scRNA-seq studies do not guarantee intact single-cell isolation, especially for sensitive and complex human endocrine tissues. Most studies rely on enzymatic dissociation of fresh samples o…
View article: Proteogenomic Alterations in PBMCs of Psoriasis Patients Recovered from COVID-19
Proteogenomic Alterations in PBMCs of Psoriasis Patients Recovered from COVID-19 Open
View article: Neodymium-Facilitated Visualization of Extreme Phosphate Accumulation in Fibroblast Filopodia: Implications for Intercellular and Cell–Matrix Interactions
Neodymium-Facilitated Visualization of Extreme Phosphate Accumulation in Fibroblast Filopodia: Implications for Intercellular and Cell–Matrix Interactions Open
A comprehensive understanding of intercellular and cell–matrix interactions is essential for advancing our knowledge of cell biology. Existing techniques, such as fluorescence microscopy and electron microscopy, face limitations in resolut…
View article: ETV2 induces endothelial, but not hematopoietic, lineage specification in birds
ETV2 induces endothelial, but not hematopoietic, lineage specification in birds Open
Cardiovascular system develops from the lateral plate mesoderm. Its three primary cell lineages (hematopoietic, endothelial, and muscular) are specified by the sequential actions of conserved transcriptional factors. ETV2 , a master regula…
View article: Comparative framework and adaptation of ACME HS approach to single cell isolation from fresh-frozen endocrine tissues
Comparative framework and adaptation of ACME HS approach to single cell isolation from fresh-frozen endocrine tissues Open
Current scRNA-seq studies of solid tissues mostly rely on enzymatic dissociation of fresh samples or the fallback on nuclei isolation from frozen or partially fixed samples. However, due to the complex tissue organization or cell fragility…
View article: The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling Open
View article: Molecular phenotyping of diverse muscle cells obtained by deep sequencing of CAGE libraries from diverse human muscle types
Molecular phenotyping of diverse muscle cells obtained by deep sequencing of CAGE libraries from diverse human muscle types Open
Here we present the results of molecular phenotyping of diverse muscle cells obtained by CAGE-Seq. The repository provides the data on aggregated gene-level read counts and allele-specific events at single-nucleotide variants in the machin…
View article: Molecular phenotyping of diverse muscle cells obtained by deep sequencing of CAGE libraries from diverse human muscle types
Molecular phenotyping of diverse muscle cells obtained by deep sequencing of CAGE libraries from diverse human muscle types Open
<p>Here we present the results of molecular phenotyping of diverse muscle cells obtained by CAGE-Seq. The repository provides the data on aggregated gene-level read counts and allele-specific events at single-nucleotide variants in t…
View article: The Developmental Transcription Factor TBX3 Physically Engages with the Wnt/β-catenin Transcriptional Complex in Human Colorectal Cancer Cells to Regulate Metastasis Genes
The Developmental Transcription Factor TBX3 Physically Engages with the Wnt/β-catenin Transcriptional Complex in Human Colorectal Cancer Cells to Regulate Metastasis Genes Open
Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear β-catenin. Furthermore, neoplasia of the colorectal epithelium begins with aberrant Wnt/β-catenin…
View article: Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations
Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations Open
We showed previously that inhibition of KIT signaling in GISTs activates FGFR-signaling pathway rendering cancer cells resistant to receptor tyrosine kinase inhibitor (RTKi) imatinib mesylate (IM) (Gleevec) despite of absence of secondary …
View article: Population Genomics of Two Closely Related Anhydrobiotic Midges Reveals Differences in Adaptation to Extreme Desiccation
Population Genomics of Two Closely Related Anhydrobiotic Midges Reveals Differences in Adaptation to Extreme Desiccation Open
The sleeping chironomid Polypedilum vanderplanki is capable of anhydrobiosis, a striking example of adaptation to extreme desiccation. Tolerance to complete desiccation in this species is associated with emergence of multiple paralogs of p…
View article: ZENBU-Reports: a graphical web-portal builder for interactive visualization and dissemination of genome-scale data
ZENBU-Reports: a graphical web-portal builder for interactive visualization and dissemination of genome-scale data Open
In the genomic era, data dissemination and visualization is an integral part of scientific publications and research projects involving international consortia producing massive genome-wide data sets, intra-organizational collaborations, o…
View article: Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology Open
View article: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology Open
In this study we use comparative genomics to uncover a gene with uncharacterized function ( 1700011H14Rik/C14orf105/CCDC198 ), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusuall…
View article: Additional file 7 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 7 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 7: Table S6. Gametologue genes impact on differential expression estimates between male and female fibroblasts
View article: Additional file 2 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 2 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 2: Table S1. Embryonic fibroblast samples statistics.
View article: Additional file 6 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 6 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 6: Table S5. Dimorphic gene enrichment per chromosome (Fisher exact test for DE genes FDR < 0.05 vs expressed genes)
View article: Additional file 8 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 8 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 8: Table S7. CAGE peaks annotation and differential expression analysis (male vs female)
View article: Additional file 3 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 3 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 3: Table S2. Transcribed promoters identification in birds fibroblasts.
View article: Additional file 4 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 4 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 4: Table S3. Numbers of differentially expressed genes between males and females samples
View article: Additional file 5 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 5 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 5: Table S4. Sex chromosome gene expression contribution to sex differences of fibroblast cultures
View article: Additional file 9 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Additional file 9 of Dosage compensation of Z sex chromosome genes in avian fibroblast cells Open
Additional file 9: Table S8. Effect of medium on RPS6 expression. Differential expression analysis for DMEM/10�S vs DMEM/F12/10�S
View article: Sex modulates the human genome regulatory network during heart failure and aging.
Sex modulates the human genome regulatory network during heart failure and aging. Open
Heart failure and other cardiomyopathies have distinct presentations in males versus females that are often overlooked, leading to ineffective treatment and the growing mortality from heart diseases. Understanding the sex dimorphism in the…
View article: Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells
Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells Open
We investigated the features of the morphology and cytokine profiles of neuroblastoma SH-SY5Y cells, bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs), and peripheral blood mononuclear cells (PBMCs) in double (BM-MSCs + SH-SY5Y …
View article: Upper cortical layer–driven network impairment in schizophrenia
Upper cortical layer–driven network impairment in schizophrenia Open
Schizophrenia is one of the most widespread and complex mental disorders. To characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) of >220,000 neurons from the dorsolateral prefrontal cortex of pa…
View article: Data related to "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al.
Data related to "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al. Open
This is Data for "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al., 2022 This repository contains: Supplementary Dataset Tables 1-4 (Supplementary_Dataset_Tables_1-4.xlsx). They contain DE gen…
View article: Data related to "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al.
Data related to "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al. Open
This is Data for "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al., 2022 This repository contains: Supplementary Dataset Tables 1-4 (Supplementary_Dataset_Tables_1-4.xlsx). They contain DE gen…