Russell G. Kerr
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View article: Discovery of Acyl-Surugamide A2 from Marine Streptomyces albidoflavus RKJM-0023—A New Cyclic Nonribosomal Peptide Containing an N-ε-acetyl-L-lysine Residue
Discovery of Acyl-Surugamide A2 from Marine Streptomyces albidoflavus RKJM-0023—A New Cyclic Nonribosomal Peptide Containing an N-ε-acetyl-L-lysine Residue Open
We report the discovery of a novel cyclic nonribosomal peptide (NRP), acyl-surugamide A2, from a marine-derived Streptomyces albidoflavus RKJM-0023 (CP133227). The structure of acyl-surugamide A2 was elucidated using a combination of NMR s…
View article: Mechanism of action of pseudopteroxazole and pseudopterosin G: Diterpenes from marine origin
Mechanism of action of pseudopteroxazole and pseudopterosin G: Diterpenes from marine origin Open
Pseudopteroxazole (Ptx) and the pseudopterosins are marine natural products with promising antibacterial potential. While Ptx has attracted interest for its antimycobacterial activity, pseudopterosins are active against several clinically …
View article: RÁPIDA CONSTRUCCIÓN DE UNA LIBRERÍA DE LOS PRODUCTOS DE CULTIVO DE 14 BACTERIAS DEL PHYLUM FIRMICUTES SIMBIONTES DEL OCTOCORAL PSEUDOPTEROGORGIA ELISABETHAE DE LA ISLA DE PROVIDENCIA (CARIBE SUR-OCCIDENTAL)
RÁPIDA CONSTRUCCIÓN DE UNA LIBRERÍA DE LOS PRODUCTOS DE CULTIVO DE 14 BACTERIAS DEL PHYLUM FIRMICUTES SIMBIONTES DEL OCTOCORAL PSEUDOPTEROGORGIA ELISABETHAE DE LA ISLA DE PROVIDENCIA (CARIBE SUR-OCCIDENTAL) Open
El presente trabajo, describe el desarrollo de una estrategia metodológica para acelerar y simplificar la detección e identificación de los compuestos producidos en cuatro medios de cultivo diferentes, por 14 bacterias del phylum Firmicute…
View article: CCDC 2078962: Experimental Crystal Structure Determination
CCDC 2078962: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Investigation of the Impact of Bacterial Microencapsulation on Natural Product Discovery
Investigation of the Impact of Bacterial Microencapsulation on Natural Product Discovery Open
View article: Investigation of the impact of bacterial microencapsulation on natural product discovery
Investigation of the impact of bacterial microencapsulation on natural product discovery Open
View article: Investigation of the impact of bacterial microencapsulation on naturalproduct discovery
Investigation of the impact of bacterial microencapsulation on naturalproduct discovery Open
Developing more effective drugs for patient care seems significantly critical, due to an alarming increase rate of antibiotic resistance and spread of cancer in society. Despite the promising potential of environmental microorganisms to pr…
View article: Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
Discovery of Levesquamide B through Global Natural Product Social Molecular Networking Open
Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide f…
View article: Draft Genome Sequence of <i>Streptomyces</i> sp. Strain RKCA744, Isolated from the Arauca River, Colombia
Draft Genome Sequence of <i>Streptomyces</i> sp. Strain RKCA744, Isolated from the Arauca River, Colombia Open
Streptomyces sp. strain RKCA744 was isolated from sediment collected from the Arauca River, Colombia.
View article: Draft Genome Sequences of Three Streptomycetes Isolated from Frobisher Bay Marine Sediments
Draft Genome Sequences of Three Streptomycetes Isolated from Frobisher Bay Marine Sediments Open
Three Streptomyces strains (RKAG290, RKAG293, and RKAG337) were isolated from intertidal marine sediments of Frobisher Bay (Canada).
View article: Microencapsulation and in situ incubation methodology for the cultivation of marine bacteria
Microencapsulation and in situ incubation methodology for the cultivation of marine bacteria Open
Environmental microorganisms are important sources of biotechnology innovations; however, the discovery process is hampered by the inability to culture the overwhelming majority of microbes. To drive the discovery of new biotechnology prod…
View article: Effects of Matrix Composition and Temperature on Viability and Metabolic Activity of Microencapsulated Marine Bacteria
Effects of Matrix Composition and Temperature on Viability and Metabolic Activity of Microencapsulated Marine Bacteria Open
To enhance the discovery of novel natural products, various innovations have been developed to aid in the cultivation of previously unculturable microbial species. One approach involving the microencapsulation of bacteria has been gaining …
View article: Complete Genome Sequence of <i>Streptomyces</i> Phage ϕRKBJ001 Isolated from Prince Edward Island, Canada
Complete Genome Sequence of <i>Streptomyces</i> Phage ϕRKBJ001 Isolated from Prince Edward Island, Canada Open
We reported here the complete genome sequence of Streptomyces phage ϕRKBJ001 that was isolated from a saltwater marsh on Prince Edward Island, Canada, using the Streptomyces sp. strain RKBHB0173. Based on electron microscopy and genomic an…
View article: Synthesis of (+)-(R)-Tiruchanduramine
Synthesis of (+)-(R)-Tiruchanduramine Open
The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.
View article: Microfabrication of a micron-scale microbial-domestication pod for <i>in situ</i> cultivation of marine bacteria
Microfabrication of a micron-scale microbial-domestication pod for <i>in situ</i> cultivation of marine bacteria Open
Through the hyphenation of microfabrication, microfluidics and microbiology, we report the development of a μMicrobial-Domestication Pod (μMD Pod) for in situ cultivation of bacteria.
View article: Microencapsulation And Subsequent In-Situ Incubation Of Marine Bacteria For The Discovery Of Novel Natural Products
Microencapsulation And Subsequent In-Situ Incubation Of Marine Bacteria For The Discovery Of Novel Natural Products Open
Despite difficulty in successfully culturing the vast majority of microbes present within the natural world, microbes continue to be a significant source of natural products.Consequently, various methods, including, but not limited to, mod…
View article: Boron-containing capsaicinoids
Boron-containing capsaicinoids Open
This study reports on the preparation of eight new boron-containing capsaicinoids bearing long aliphatic chains, and initial bioactivities are reported.
View article: Comparative Microbiome and Metabolome Analyses of the Marine Tunicate Ciona intestinalis from Native and Invaded Habitats
Comparative Microbiome and Metabolome Analyses of the Marine Tunicate Ciona intestinalis from Native and Invaded Habitats Open
Massive fouling by the invasive ascidian Ciona intestinalis in Prince Edward Island (PEI, Canada) has been causing devastating losses to the local blue mussel farms. In order to gain first insights into so far unexplored factors that may c…
View article: Development of 3D Printed Drug-Eluting Scaffolds for Preventing Piercing Infection
Development of 3D Printed Drug-Eluting Scaffolds for Preventing Piercing Infection Open
Herein, novel drug-eluting, bio-absorbable scaffold intended to cover piercing studs is introduced. This “biopierce” will stay in human tissue following piercing, and will slowly release an antimicrobial agent to prevent infection while th…
View article: Optimization of Marine Bacteria Microencapsulation for the Discovery of Novel Marine Natural Products
Optimization of Marine Bacteria Microencapsulation for the Discovery of Novel Marine Natural Products Open
Marine natural products produced by microbes represent an indispensable resource for various biotechnological applications, including use as medicines, dietary supplements, personal care products and diagnostic agents.However, the discover…
View article: CCDC 2013466: Experimental Crystal Structure Determination
CCDC 2013466: Experimental Crystal Structure Determination Open
View article: Pseudopterosin and O-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma
Pseudopterosin and O-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma Open
Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in …
View article: Draft Genome Sequence of Streptomyces sp. Strain RKND-216, an Antibiotic Producer Isolated from Marine Sediment in Prince Edward Island, Canada
Draft Genome Sequence of Streptomyces sp. Strain RKND-216, an Antibiotic Producer Isolated from Marine Sediment in Prince Edward Island, Canada Open
Streptomyces sp. strain RKND-216 was isolated from marine sediment collected in Prince Edward Island, Canada, and produces a putatively novel bioactive natural product with antitubercular activity. The genome assembly consists of two conti…
View article: Discovery of Primarolides A and B from Marine Fungus Asteromyces cruciatus Using Osmotic Stress and Treatment with Suberoylanilide Hydroxamic Acid
Discovery of Primarolides A and B from Marine Fungus Asteromyces cruciatus Using Osmotic Stress and Treatment with Suberoylanilide Hydroxamic Acid Open
Advances in whole-genome sequencing of many fungal species has revealed the presence of numerous “silent” biosynthetic genes, highlighting their potential to produce a wide variety of natural products. These silent biosynthetic genes are r…
View article: Draft Genome Sequence of <i>Alteromonas</i> sp. Strain RKMC-009, Isolated from <i>Xestospongia muta</i> via <i>In Situ</i> Culturing Using an Isolation Chip Diffusion Chamber
Draft Genome Sequence of <i>Alteromonas</i> sp. Strain RKMC-009, Isolated from <i>Xestospongia muta</i> via <i>In Situ</i> Culturing Using an Isolation Chip Diffusion Chamber Open
We report the draft whole-genome sequence of Alteromonas sp. strain RKMC-009, which was isolated in situ from the sponge Xestospongia muta in San Salvador, The Bahamas, using an isolation chip (ichip). Automated biosynthetic gene cluster a…
View article: Terrosamycins A and B, Bioactive Polyether Ionophores from Streptomyces sp. RKND004 from Prince Edward Island Sediment
Terrosamycins A and B, Bioactive Polyether Ionophores from Streptomyces sp. RKND004 from Prince Edward Island Sediment Open
Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach cou…
View article: Discovery of a New Natural Product and a Deactivation of a Quorum Sensing System by Culturing a “Producer” Bacterium With a Heat-Killed “Inducer” Culture
Discovery of a New Natural Product and a Deactivation of a Quorum Sensing System by Culturing a “Producer” Bacterium With a Heat-Killed “Inducer” Culture Open
Herein we describe a modified bacterial culture methodology as a tool to discover new natural products via supplementing actinomycete fermentation media with autoclaved cultures of "inducer" microbes. Using seven actinomycetes and four ind…
View article: Microfluidic and cross-linking methods for encapsulation of living cells and bacteria - A review
Microfluidic and cross-linking methods for encapsulation of living cells and bacteria - A review Open
View article: Temperature and pH effect on glucose production from pretreated bagasse by a novel species of Citrobacter and other bacteria
Temperature and pH effect on glucose production from pretreated bagasse by a novel species of Citrobacter and other bacteria Open
View article: Characterization of Actinobacterial Communities from Arauca River Sediments (Colombia) Reveals Antimicrobial Potential Presented in Low Abundant Isolates
Characterization of Actinobacterial Communities from Arauca River Sediments (Colombia) Reveals Antimicrobial Potential Presented in Low Abundant Isolates Open
Introduction: New strategies have been arisen to set a rapid and effective screening for selection of microorganism with bioactive potential. This study suggests that combination of physicochemical pretreatments and taxonomic dereplication…