Explanipedia

Dysregulation of SELENOI Is Associated with TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis Open

Finula I. Isik, Jasmin Galper, Russell Pickford, Nicolas Dzamko, YuHong Fu , et al. · 2025

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by progressive degeneration of motor neurons and accumulation of TAR DNA-binding protein 43 (TDP-43) in the brain. Increasing evidence indicates that…

Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy Open

Finula I. Isik, YuHong Fu, Russell Pickford, Qi Cheng, Yue Yang , et al. · 2025

Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α‐synuclein aggregates. In Parkinson's disease, increases in monounsatur…

Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs Open

Julie A.I. Thoms, Feng Yan, Henry R. Hampton, Sarah Davidson, Swapna Joshi , et al. · 2025

Hypomethylating agents are frontline therapies for myelodysplastic neoplasms (MDS), yet clinical responses remain unpredictable. We conducted a phase 2 trial comparing injectable and oral azacitidine (AZA) administered over one or three we…

The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia Open

Cara E. Toscan, Hannah McCalmont, Amir Ashoorzadeh, Xiaojing Lin, Zhe Fu , et al. · 2024

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that expresses high levels of the enzyme aldo-keto reductase family 1 member C3 (AKR1C3). To exploit this finding, we developed a novel prodrug, ACHM-025…

Mapping the lipidomic secretome of the early equine embryo Open

Edwina F Lawson, Russell Pickford, R. John Aitken, Zamira Gibb, Christopher G. Grupen , et al. · 2024

The lipidomic secretions of embryos provide a unique opportunity to examine the cellular processes of the early conceptus. In this study we profiled lipids released by the early equine conceptus, using high-resolution mass spectrometry to …

Biotransformation of 6:2/4:2 fluorotelomer alcohols by Dietzia aurantiaca J3: Enzymes and proteomics Open

Shefali Bhardwaj, Matthew Lee, Denis M. O’Carroll, James A. McDonald, Keith Osborne , et al. · 2024

Per- and polyfluoroalkyl substances (PFAS) are recalcitrant synthetic organohalides known to negatively impact human health. Short-chain fluorotelomer alcohols are considered the precursor of various perfluorocarboxylic acids (PFCAs) in th…

Prediction of motor and non-motor Parkinson’s disease symptoms using serum lipidomics and machine learning: a 2-year study Open

Jasmin Galper, Giorgia Mori, Gordon McDonald, Diba Ahmadi Rastegar, Russell Pickford , et al. · 2024

Identifying biological factors which contribute to the clinical progression of heterogeneous motor and non-motor phenotypes in Parkinson’s disease may help to better understand the disease process. Several lipid-related genetic risk factor…

Soluble metal porphyrins - Zero-valent zinc system for effective reductive defluorination of branched per and polyfluoroalkyl substances (PFASs) Open

Jun Sun, Tsz Tin Yu, Maryam Mirabediny, Matthew Lee, Adele M. Jones , et al. · 2024

Nano zero-valent metals (nZVMs) have been extensively utilized for decades in the reductive remediation of groundwater contaminated with chlorinated organic compounds, owing to their robust reducing capabilities, simple application, and co…

A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson’s disease Open

YuHong Fu, Russell Pickford, Jasmin Galper, Katherine Phan, Ping Wu , et al. · 2024

Electrochemical degradation of a C6-perfluoroalkyl substance (PFAS) using a simple activated carbon cathode Open

Diana Ackerman Grunfeld, Adele M. Jones, Jun Sun, Song Thao Le, Russell Pickford , et al. · 2023

This scoping study investigates the ability of an inexpensive, commercially available granular activated carbon (GAC) to sorb and conduct electrical charge to achieve reductive defluorination of PFAS.

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia Open

Ernest Moles, Christopher B. Howard, Pie Huda, Mawar Karsa, Hannah McCalmont , et al. · 2023

High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and tolerability of ch…

PEMT Mediates Hepatitis C Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication Open

Mosleh Mohammad Abomughaid, Enoch Tay, Russell Pickford, Chandra S. Malladi, Scott Read , et al. · 2023

The hepatitis C virus (HCV) relies on cellular lipid pathways for virus replication and also induces liver steatosis, but the mechanisms involved are not clear. We performed a quantitative lipidomics analysis of virus-infected cells by com…

Human tear metabolites associated with nucleoside-signalling pathways in bacterial keratitis Open

Gauri Shankar Shrestha, Ajay Kumar Vijay, Fiona Stapleton, Andrew White, Russell Pickford , et al. · 2023

Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis Open

Katherine Phan, Ying He, Surabhi Bhatia, Russell Pickford, Gordon McDonald , et al. · 2022

Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and loss of various muscular functions. Dyslipidaemia is prevalent in amyotrophic lateral sclerosis with ab…

In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial Open

John E. Pimanda, Julie A.I. Thoms, Henry R. Hampton, Sarah Davidson, Swapna Joshi , et al. · 2022

Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain Open

YuHong Fu, Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford , et al. · 2022

Assessing the efficacy of albendazole against hookworm in Vietnam using quantitative PCR and sodium nitrate flotation Open

C. Dyer, Naomi E. Clarke, Dinh Ng Nguyen, H.M.P. Dilrukshi Herath, Sze Fui Hii , et al. · 2022

Preventive chemotherapy (PC), consisting of the regular distribution of anthelmintics to populations or groups of populations at risk, is the primary tool used to control soil-transmitted helminth (STH) infections. This strategy, whilst co…

Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease Open

Jasmin Galper, Nicholas Dean, Russell Pickford, Simon J.G. Lewis, Glenda M. Halliday , et al. · 2022

Many genetic risk factors for Parkinson’s disease have lipid-related functions and lipid-modulating drugs such as statins may be protective against Parkinson’s disease. Moreover, the hallmark Parkinson’s disease pathological protein, α-syn…

Sex-specific lipid dysregulation in the Abca7 knockout mouse brain Open

YuHong Fu, Ying He, Katherine Phan, Russell Pickford, Young‐Bum Kim , et al. · 2022

Alzheimer’s disease is a devastating neurodegenerative disease that affects more women than men. The pathomechanism underlying the sex disparity, especially in the brain, is unclear. ABCA7 is one of the strongest susceptibility genes for A…

Aerobic biotransformation of 6:2 fluorotelomer sulfonate by Dietzia aurantiaca J3 under sulfur-limiting conditions Open

Valentina Méndez, Sophie I. Holland, Shefali Bhardwaj, James A. McDonald, Stuart J. Khan , et al. · 2022

The polyfluorinated alkyl substance 6:2 fluorotelomer sulfonate (6:2 FTS) has been detected in diverse environments impacted by aqueous film-forming foams used for firefighting. In this study, a bacterial strain (J3) using 6:2 FTS as a sul…

Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia Open

Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, YuHong Fu , et al. · 2021

Tear metabolite expression in bacterial keratitis: Outcomes of an untargeted approach Open

Gauri Shankar Shrestha, Ajay Kumar Vijay, Fiona Stapleton, Andrew White, Russell Pickford , et al. · 2021

Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes Open

Yue Liu, Anbupalam Thalamuthu, Karen A. Mather, John D. Crawford, Marina Ulanova , et al. · 2021

Simultaneous Fe3O4 Nanoparticle Formation and Catalyst-Driven Hydrothermal Cellulose Degradation Open

Alexander Wotton, Tracey Yeung, Sreenu Jennepalli, Zhi Li Teh, Russell Pickford , et al. · 2021

Breakdown and utilization of cellulose are critical for the bioenergy sector; however, current cellulose-to-energy conversion schemes often consume large quantities of unrecoverable chemicals, or are expensive, due to the need for enzymes …

Metabolomics shows the Australian dingo has a unique plasma profile Open

Sonu Yadav, Russell Pickford, Robert A. Zammit, J. William O. Ballard · 2021

Dingoes occupy a wide range of the Australian mainland and play a crucial role as an apex predator with a generalist omnivorous feeding behaviour. Dingoes are ecologically, phenotypically and behaviourally distinct from modern breed dogs a…

Cover Feature: Heterologous Expression of an Unusual Ketosynthase, SxtA, Leads to Production of Saxitoxin Intermediates in Escherichia coli (5/2021) Open

Angela H. Soeriyadi, Rabia Mazmouz, Russell Pickford, Bakir Al‐Sinawi, Ralf Kellmann , et al. · 2021

Saxitoxins are neurotoxic alkaloids produced by cyanobacteria and dinoflagellates. Due to their antagonism of voltage-gated sodium channels, they are desirable candidates for drug development as anaesthetics and muscle relaxants. We descri…

Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation Open

Nicky Jonkhout, Sonia Cruciani, Helaine Graziele Santos Vieira, Julia Tran, Huanle Liu , et al. · 2021

RNA modifications are dynamic chemical entities that expand the RNA lexicon and regulate RNA fate. The most abundant modification present in mRNAs, N6-methyladenosine (m⁶A), has been implicated in neurogenesis and memory formati…

Human Tear Metabolomics Using Liquid Chromatography-Q Exactive-HF Mass Spectrometry Open

Gauri Shankar Shrestha, Ajay Kumar Vijay, Fiona Stapleton, Russell Pickford, Nicole Carnt · 2021

Aim To putatively identify and characterise human tear metabolites in a normal subject on an untargeted platform of liquid chromatography-Q exactive-HF mass spectrometry. Methods Four samples of unstimulated tears were collected from both …

Metabolomics shows the Australian dingo has a unique plasma profile Open

Sonu Yadav, Russell Pickford, Robert A. Zammit, J. William O. Ballard · 2020

Dingoes have not been artificially selected in the past 3,500 years. They occupy a wide range of the Australian mainland and play a crucial role as an apex predator with a generalist omnivorous feeding behaviour. In contrast, humans have s…

Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation Open

Nicky Jonkhout, Sonia Cruciani, Helaine Graziele Santos Vieira, Julia Tran, Huanle Liu , et al. · 2020

RNA modifications are dynamic chemical entities that regulate RNA fate, and an avenue for environmental response in neuronal function. However, which RNA modifications may be playing a role in neuronal plasticity and environmental response…

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