Explanipedia

High-protein oral nutritional supplement use in patients with cancer reduces complications and length of hospital stay: a systematic review and meta-analysis Open

Marta Delsoglio, R. Capener, Trevor Smith, Mhairi Donald, Gary P. Hubbard , et al. · 2025

Introduction Oral nutritional supplements (ONS) have been reported to improve nutritional status, quality of life and clinical outcomes in many patient groups. This systematic review investigated the effects of high-protein ONS (HPONS), ≥2…

Management of type 1 (acute) intestinal failure Open

Priya Mistry, Hannah Leach, Elizabeth Buse, Trevor Smith · 2025

Intestinal failure (IF) is defined as ‘the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/o…

Scalable Cost-Optimized HPC Cluster on Google Cloud Platform Open

Doğukan Teber, Tristan Kosciuch, Elchin Jafarov, Benjamin Maglio, Brendan M. Rogers , et al. · 2025

High-Performance Computing (HPC) clusters are essential for researchers handling complex computational tasks and big data analysis; yet, access to these powerful resources remains constrained. Most researchers rely on shared super-computin…

Randomised Trial Shows Readymade Oral Nutritional Supplements in Older Malnourished People in the Community Improve Total Nutrient Intakes and Meet More Dietary Reference Values Without Reducing Intake from the Diet Open

Marinos Elia, Trevor Smith, Abbie L. Cawood, Emily R. Walters, R.J. Stratton · 2025

Background: There is little information about the effectiveness of oral nutritional supplements (ONS) in combatting nutrient inadequacies in primary care, where most malnutrition exists. Aim: To examine the extent to which readymade ONS ad…

Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra‐Articular Injections of Biologic Agents Open

Johanna M. Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian , et al. · 2025

Objective Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic inject…

Human-Centered Design and Iterative Refinement of Tools and Methods to Implement a Surveillance and Risk Prediction System for Clinical Deterioration in Ambulatory Cancer Care Open

Daniel J. France, Paromita Nath, Jason Slagle, Shilo Anders, Megan E. Salwei , et al. · 2025

Background A common cause of preventable harm is the failure to detect and appropriately respond to clinical deterioration. Timely intervention is needed, particularly in medically complex patients, to mitigate the effects of adverse event…

Understanding health inequalities through emergency department walk-in data Open

Christopher Johnes, Trevor Smith · 2024

Introduction: Emergency Departments are under considerable pressure, with the number of attendances increasing alongside a considerable backlog of patients waiting for treatment. Across England, A&E attendances and emergency admissions in …

Damage to medical complexes in the Gaza Strip during the Israel–Hamas war: a geospatial analysis Open

Danielle N. Poole, Daniel Andersen, Nathaniel A. Raymond, Rob Grace, Trevor Smith , et al. · 2024

Introduction Medical facilities are civilian objects specially protected during armed conflict by international humanitarian law (IHL). These protections are customarily applied regardless of the conflict, parties or contexts involved. Att…

Gastroenterology trainee experience, confidence and satisfaction in nutrition training: a cross-sectional survey in the UK Open

Stephanie Sartain, Charlotte Wong, Emma Murray, Suneil A Raju, Amy Woods , et al. · 2024

Introduction Nutrition is an essential part of gastroenterology specialist training. There is limited evidence of trainee experience in this area. The shorter training programme introduced in 2022 may lead to reduced exposure to this subsp…

Follow-up of patients with coeliac disease: Experience from a virtual clinic Open

Adam McCulloch, Andrew A.F. Sanderson, John P. Wyatt, M. Abosamra, M. Dingwall , et al. · 2023

A systematic review and meta-analysis of the effects of community use of oral nutritional supplements on clinical outcomes Open

A.L. Cawood, Sorrel Burden, Trevor Smith, R.J. Stratton · 2023

The impact of oral nutritional supplements (ONS) on patients with complications (disease related morbidity) requires further exploration. This systematic review included 44 randomised controlled trials (RCT) (29 RCT surgical, 15 RCT medica…

United Kingdom artificial nutrition database: The changing landscape of adult home parenteral support Open

Mani Naghibi, Alexandros Toskas, James Willsmore, Trevor Smith, Sarah Jane Hughes , et al. · 2023

Background The United Kingdom nutrition database monitors the changing landscape of adult home parenteral nutrition support (HPS) to inform clinicians and policy makers of the need for this life‐saving treatment. Methods The UK database is…

A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort Open

Michael R. Ardern‐Jones, Hang Phan, Florina Borca, Matthew Stammers, James Batchelor , et al. · 2023

Background The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that …

Long overdue: undergraduate nutrition education for medical students Open

Bernard M. Corfe, Trevor Smith, Nicola Heslehurst, Jeremy M. D. Nightingale, Sue Kenneally , et al. · 2022

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Optimisation of COVID‐19 diagnostic pathways in acute hospital admissions to prevent nosocomial transmission Open

Robert Livingstone, Alexander Woodhead, Megha Bhandari, James A. Dias, Trevor Smith , et al. · 2022

Introduction In the management of acute hospital admissions during the COVID‐19 pandemic, safe patient cohorting depends on robust admission diagnostic strategies. It is essential that screening strategies are sensitive and rapid, to preve…

Impact of direct-access IBD physician delivered endoscopy on clinical outcomes: a pre-implementation and post-implementation study Open

Matthew Stammers, Sohail Rahmany, Louise Downey, Florina Borca, Clare Harris , et al. · 2022

Introduction Patients with suspected inflammatory bowel disease (IBD) referred from primary care often face diagnostic and treatment delays. This study aimed to compare a novel direct-access IBD endoscopy pathway with the traditional care …

Routine molecular point-of-care testing for SARS-CoV-2 reduces hospital-acquired COVID-19 Open

Robert Livingstone, Hlaing Lin, Nathan J. Brendish, Stephen Poole, Alex Tanner , et al. · 2022

Transitioning from Intravenous to Subcutaneous Vedolizumab in Patients with Inflammatory Bowel Disease [TRAVELESS] Open

Esther Ventress, David Young, Sohail Rahmany, Clare Harris, Marion Bettey , et al. · 2021

Background and Aims Subcutaneous [SC] vedolizumab presents the opportunity for inflammatory bowel disease [IBD] patients to manage their treatment at home. There are currently no data on the process of transitioning patients established on…

PMO-15 Transitioning from intravenous to subcutaneous vedolizumab in patients with inflammatory bowel disease (TRAVELESS) Open

Esther Ventress, Sohail Rahmany, David Young, Marion Bettey, Clare Harris , et al. · 2021

Introduction In May 2020, subcutaneous (SC) vedolizumab was approved for use in Inflammatory Bowel Disease (IBD). Patients with IBD have a number of risk factors for a poor outcome from SARS-CoV-2 infection and managing this risk by reduci…

Powered Respirators Are Effective, Sustainable, and Cost-Effective Personal Protective Equipment for SARS-CoV-2 Open

Alasdair Munro, Jacqui Prieto, Emmanouil Mentzakis, Mohammed Dibas, Nitin Mahobia , et al. · 2021

Objectives: The provision of high-quality personal protective equipment (PPE) has been a critical challenge during the COVID-19 pandemic. We evaluated an alternative strategy, mass deployment of a powered air-purifying respirator (PeRSo), …

Secondary haemophagocytic lymphohistiocytosis in hospitalised COVID-19 patients as indicated by a modified HScore is infrequent and high scores do not associate with increased mortality Open

Michael R. Ardern‐Jones, Matthew Stammers, Hang Phan, Florina Borca, Anastasia Koutalopoulou , et al. · 2021

Supporting people who have eating and drinking difficulties Open

Karen Porter, Nicola Burch, Claire Campbell, Christopher Danbury, Charles Foster , et al. · 2021

Eating and drinking are essential for maintenance of nutrition and hydration, but are also important for pleasure and social interactions. The ability to eat and drink hinges on a complex and coordinated system, resulting in significant po…

A novel hyperinflammation clinical risk tool, HI5-NEWS2, predicts mortality following early dexamethasone use in an observational cohort of hospitalised COVID-19 patients Open

Michael R. Ardern‐Jones, Hang Phan, Florina Borca, Matthew Stammers, James Batchelor , et al. · 2021

Background The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that …

Malnutrition risk in hospitalised COVID-19 patients receiving CPAP Open

Pete Turner, Hugh Montgomery, Mike Stroud, G. Grimble, Trevor Smith · 2021

Diabetes Insipidus: Pathogenesis, Diagnosis, and Clinical Management Open

Cody M Mutter, Trevor Smith, Olivia Menze, Mariah Zakharia, Hoang Nguyen · 2021

O69 Outcome of direct access IBD physician delivered endoscopy for general practice referrals with suspected IBD Open

Sohail Rahmany, Matthew Stammers, Louise Downey, Trevor Smith, Richard Felwick , et al. · 2021

Introduction: patients with suspected IBD referred by primary care (GP) are traditionally seen in gastroenterology outpatient clinics followed by endoscopic investigations. This 2 phase model leads to delay in diagnosis and treatment, incr…

P286 Hit and miss? The monitoring of intestinal failure associated liver disease Open

Melissa Zhao, Emily J. Clarke, Thomas Hollingworth, Janisha Patel, Trevor Smith , et al. · 2021

Introduction Intestinal failure associated liver disease (IFALD) is a complication in patients with intestinal failure (IF) on home parenteral nutrition (HPN). It can progress to cirrhosis requiring a combined liver-intestinal transplant w…

A Novel Hyperinflammation Clinical Risk Tool, HI5-NEWS2, Predicts Mortality Following Early Dexamethasone Use in an Observational Cohort of Hospitalised COVID-19 Patients Open

Michael R. Ardern‐Jones, Hang Phan, Florina Borca, Matthew Stammers, James Batchelor , et al. · 2021

P168 Tofacitinib in ulcerative colitis: early real-world experience in Southampton Open

David Young, Esther Ventress, Richard Harris, Martin B. McDonnell, Marion Bettey , et al. · 2021

Introduction The landscape of medical therapies for severe ulcerative colitis is widening. Tofacitinib, the first oral therapy and Janus kinase (JAK) inhibitor to be approved for this indication, was licensed in the EU in August 2018 and w…

P285 Are there new tools to assess fibrosis in IFALD? Open

Melissa Zhao, Emily J. Clarke, Thomas Hollingworth, Janisha Patel, Trevor Smith , et al. · 2021

Introduction Intestinal failure associated liver disease (IFALD) refers to liver injury due to intestinal failure (IF) and parenteral nutrition (PN). This presents as steatosis and cholestasis which can lead to fibrosis and cirrhosis. ESPE…

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