Rustam Ziganshin
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View article: Comparative Preclinical Evaluation of the Tumor-Targeting Properties of Radioiodine and Technetium-Labeled Designed Ankyrin Repeat Proteins for Imaging of Epidermal Growth Factor Receptor Expression in Malignant Tumors
Comparative Preclinical Evaluation of the Tumor-Targeting Properties of Radioiodine and Technetium-Labeled Designed Ankyrin Repeat Proteins for Imaging of Epidermal Growth Factor Receptor Expression in Malignant Tumors Open
Radionuclide molecular imaging of epidermal growth factor receptor (EGFR) expression might permit the selection of patients for EGFR-targeting therapies. Designed ankyrin repeat protein (DARPin) E01 with a high affinity to the ectodomain I…
View article: Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment
Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment Open
Spinal cord injury (SCI) is a medical challenge that results in the formation of a glial scar preventing recovery of axonal conductivity. Cytokines and chemokines significantly affect the pathogenesis of SCI and represent important targets…
View article: HOXB13 interactome in prostate cancer cells: biochemical and functional interactions between the transcription factors HOXB13 and TBX3
HOXB13 interactome in prostate cancer cells: biochemical and functional interactions between the transcription factors HOXB13 and TBX3 Open
Transcription factors represent one of the major groups of proteins, whose suppression leads to tumor growth arrest. Different types of cancer express a specific set of transcription factors that create and maintain unique patterns of gene…
View article: Hsp70 Peptides Induce TREM-1-Dependent and TREM-1-Independent Activation of Cytotoxic Lymphocytes
Hsp70 Peptides Induce TREM-1-Dependent and TREM-1-Independent Activation of Cytotoxic Lymphocytes Open
The novel data show that the Hsp70 protein is a potent activator of the immune system. Using limited trypsinolisis, we have identified the epitopes of Hsp70 responsible for TREM-1-dependent and TREM-1-independent cytotoxicity. The 11aa N9 …
View article: P01.34.B MEMBRANE-BOUND EPICHAPEROME SUPPORTS MOLECULAR NETWORKS FACILITATING GLIOBLASTOMA CELL MIGRATION AND INVASION
P01.34.B MEMBRANE-BOUND EPICHAPEROME SUPPORTS MOLECULAR NETWORKS FACILITATING GLIOBLASTOMA CELL MIGRATION AND INVASION Open
BACKGROUND Heat shock proteins (HSP), in particular representatives of the HSP70 and HSP90 families, which are the folding centers of almost all cell proteins, have a wide range of interactions,which includes many molecules involved in cel…
View article: P01.29.A GLIOBLASTOMA CELL MOTILITY AND INVASION IS REGULATED BY MEMBRANE-ASSOCIATED HEAT SHOCK PROTEIN HSP70
P01.29.A GLIOBLASTOMA CELL MOTILITY AND INVASION IS REGULATED BY MEMBRANE-ASSOCIATED HEAT SHOCK PROTEIN HSP70 Open
BACKGROUND Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor which characterized by a high ability to migrate and invade into surrounding brain tissue. The main problem in therapy is the tumor’s high invasiveness. Th…
View article: P01.22.B MEMBRANE-BOUND HEAT SHOCK PROTEINS: MHSP70 AS A TARGET FOR THERANOSTICS IN NEURO-ONCOLOGY
P01.22.B MEMBRANE-BOUND HEAT SHOCK PROTEINS: MHSP70 AS A TARGET FOR THERANOSTICS IN NEURO-ONCOLOGY Open
BACKGROUND Heat shock protein mHsp70 can be exposed on the surface of the plasma membrane of tumor cells. We demonstrate that mHsp70 of malignant brain tumors is required for high migratory and invasive activity of cancer cells and can ser…
View article: Development of quality control techniques of chemical precursor – recombinant protein with ankyrin repeats for radionuclide imaging of HER2 overexpression in malignant tumors
Development of quality control techniques of chemical precursor – recombinant protein with ankyrin repeats for radionuclide imaging of HER2 overexpression in malignant tumors Open
Introduction. Overexpression of the HER2 receptor is associated with aggressive cancer progression and poor prognosis. Traditional immunohistochemical diagnostics have a number of limitations, including invasiveness, inability to assess tu…
View article: The role of membrane-associated heat shock protein Hsp70 in migration of glioblastoma cell
The role of membrane-associated heat shock protein Hsp70 in migration of glioblastoma cell Open
Background . Membrane-associated heat shock protein Hsp70 (mHsp70) is selectively expressed in tu mor, but not in normal cells. The mHsp70 functions are not fully understood. Objective : to study the role of mHsp70 in glioblastoma cell mig…
View article: Adaptation of the Protocol for the Isolation of Biotinylated Protein Complexes for Drosophila melanogaster Tissues
Adaptation of the Protocol for the Isolation of Biotinylated Protein Complexes for Drosophila melanogaster Tissues Open
Proximity biotinylation, which utilizes various biotin ligating enzymes (BioID, TurboID, etc.), is widely used as a powerful tool for identifying novel protein–protein interactions. However, this method has a significant limitation: the us…
View article: Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy
Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy Open
View article: The new perspective on understanding the mechanisms of cardiovascular diseases development
The new perspective on understanding the mechanisms of cardiovascular diseases development Open
Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. From a modern point of view, endothelial dysfunction is considered as a key factor leading to the development of CVD. However, scientists have suggested that t…
View article: Glioblastoma cell motility and invasion is regulated by membrane-associated heat shock protein Hsp70
Glioblastoma cell motility and invasion is regulated by membrane-associated heat shock protein Hsp70 Open
View article: A green dichromophoric protein enabling foliage mimicry in arthropods
A green dichromophoric protein enabling foliage mimicry in arthropods Open
Molecular mechanisms underlying the green insect camouflage have puzzled researchers for over a century. Here, we isolated and identified a green water-soluble protein from the integument of bush-cricket Tettigonia cantans . De novo sequen…
View article: Growth physiology, genomics, and proteomics of Desulfurivibrio dismutans sp. nov., an obligately chemolithoautotrophic, sulfur disproportionating and ammonifying haloalkaliphile from soda lakes
Growth physiology, genomics, and proteomics of Desulfurivibrio dismutans sp. nov., an obligately chemolithoautotrophic, sulfur disproportionating and ammonifying haloalkaliphile from soda lakes Open
Elemental sulfur disproportionation combined with obligate autotrophy is a unique type of sulfur-based anaerobic metabolism known in a limited number of bacteria, primarily found among the members of Desulfobacterota phylum. Until recently…
View article: The divergent intron-containing actin in sponge morphogenetic processes
The divergent intron-containing actin in sponge morphogenetic processes Open
The ability of eukaryotic cells to orchestrate mechanical interactions from the subcellular to the organismal levels is mediated by their cytoskeleton. One of the key components of the eukaryotic cytoskeleton is actin, a highly conserved b…
View article: Supplementary Figure S5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Evaluation of biomarkers co-localization.
View article: Supplementary Figure S10 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S10 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Confocal microscopy images of primary glioblastoma cells from patients stained for mHsp70 and Nestin.
View article: Supplementary Table S3 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Table S3 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Characteristics of patients with brain metastases.
View article: Supplementary Table S5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Table S5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
List of proteins detected by mass spectrometric analysis of lipid rafts isolated from normal brain tissue (obtained from a patient with epilepsy).
View article: Video S6 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Video S6 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Cells of the TMS cell line in the well with the addition of a PES inhibitor on the matrigel matrix.
View article: Supplementary Figure S3 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S3 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Preparing a tumor sample for confocal microscopy.
View article: Video S4 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Video S4 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Migration of cells out of spheroids. TMS cell line, a well without the addition of inhibitors on a Poly-L-lysine matrix.
View article: Video S5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Video S5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Automatic cell tracking before the AI model is applied. TMS cell line, a well without the addition of inhibitors on a Poly-L-lysine matrix.
View article: Supplementary Figure S1 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S1 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Gating of mHsp70High cells (field R2) and mHsp70Low cells (field R3) by FACS.
View article: Supplementary Figure S2 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S2 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
CD133 expression in C6, T98G and U251 cell lines measured by flow cytometry.
View article: Supplementary Table S1 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Table S1 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Characteristics of adult patients with high-grade gliomas.
View article: Supplementary Figure S11 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S11 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Comparison of mean speed and track straightness on various matrices (PL, MG, FN) of patient-derived (non-sorted into high- and low-speed subpopulations) brain tumor cells treated with 1 µM PES or 50 nM JG-98.
View article: Supplementary Figure S8 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Figure S8 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Effect of Hsp70 inhibitors PES and JG-98 on cell viability analyzed using the MTT assay.
View article: Supplementary Table S2 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors
Supplementary Table S2 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors Open
Characteristics of pediatric patients with high-grade gliomas.