Rūta Prakapaitė
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View article: Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic <i>Escherichia coli</i> in human urine
Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic <i>Escherichia coli</i> in human urine Open
Urinary tract infections (UTIs) are among the most common infectious diseases, causing over 400 million cases and 260,000 deaths annually. Women are disproportionately affected, with ∼50% experiencing at least one UTI during their lifetime…
View article: Synthesis and Characterization of Sulfonamide‐Imidazole Hybrids with In Vitro Antiproliferative Activity against Anthracycline‐Sensitive and Resistant H69 Small Cell Lung Cancer Cells
Synthesis and Characterization of Sulfonamide‐Imidazole Hybrids with In Vitro Antiproliferative Activity against Anthracycline‐Sensitive and Resistant H69 Small Cell Lung Cancer Cells Open
A series of novel sulfonamide‐imidazole hybrid derivatives are synthesized, and their antiproliferative properties are evaluated. The global challenge of cancer, highlighted by rising morbidity and mortality rates, is further intensified b…
View article: Integrated Analysis of Patient Networks and Plasmid Genomes to Investigate a Regional, Multispecies Outbreak of Carbapenemase-Producing Enterobacterales Carrying Both <i>bla</i> IMP and <i>mcr-9</i> Genes
Integrated Analysis of Patient Networks and Plasmid Genomes to Investigate a Regional, Multispecies Outbreak of Carbapenemase-Producing Enterobacterales Carrying Both <i>bla</i> IMP and <i>mcr-9</i> Genes Open
Background Carbapenemase-producing Enterobacterales (CPE) are challenging in healthcare, with resistance to multiple classes of antibiotics. This study describes the emergence of imipenemase (IMP)–encoding CPE among diverse Enterobacterale…
View article: Molecular Epidemiology of Group B Streptococci in Lithuania Identifies Multi-Drug Resistant Clones and Sporadic ST1 Serotypes Ia and Ib
Molecular Epidemiology of Group B Streptococci in Lithuania Identifies Multi-Drug Resistant Clones and Sporadic ST1 Serotypes Ia and Ib Open
Streptococcus agalactiae (Group B Streptococcus, GBS) is a leading cause of neonatal infections. Yet, detailed assessment of the genotypic and phenotypic factors associated with GBS carriage, mother-to-baby transmission, and GBS infection …
View article: A New Sugar for an Old Phage: a c-di-GMP-Dependent Polysaccharide Pathway Sensitizes <i>Escherichia coli</i> for Bacteriophage Infection
A New Sugar for an Old Phage: a c-di-GMP-Dependent Polysaccharide Pathway Sensitizes <i>Escherichia coli</i> for Bacteriophage Infection Open
Because bacterial surface glycans are in direct contact with the environment they can provide essential protective functions during infections or against competing bacteria. But such structures are also “Achilles’ heels” since they can ser…
View article: Integrated analysis of patient networks and plasmid genomes reveals a regional, multi-species outbreak of carbapenemase-producing Enterobacterales carrying both<i>bla</i><sub>IMP</sub>and<i>mcr-9</i>genes
Integrated analysis of patient networks and plasmid genomes reveals a regional, multi-species outbreak of carbapenemase-producing Enterobacterales carrying both<i>bla</i><sub>IMP</sub>and<i>mcr-9</i>genes Open
Background Carbapenemase-producing Enterobacterales (CPE) are challenging in the healthcare setting, with resistance to multiple classes of antibiotics and a high associated mortality. The incidence of CPE is rising globally, despite enhan…
View article: A new sugar for an old phage: A c-di-GMP dependent polysaccharide pathway sensitizes <i>E. coli</i> for bacteriophage infection
A new sugar for an old phage: A c-di-GMP dependent polysaccharide pathway sensitizes <i>E. coli</i> for bacteriophage infection Open
Bacteriophages are ubiquitous parasites of bacteria and major drivers of bacterial ecology and evolution. Despite an ever-growing interest in their biotechnological and therapeutic applications, detailed knowledge of the molecular mechanis…
View article: Molecular Characterization of Uropathogenic Escherichia coli Reveals Emergence of Drug Resistant O15, O22 and O25 Serogroups
Molecular Characterization of Uropathogenic Escherichia coli Reveals Emergence of Drug Resistant O15, O22 and O25 Serogroups Open
Background and Objectives: Uropathogenic Escherichia coli (UPEC) are common pathogens causing urinary tract infections (UTIs). We aimed to investigate the relationship among clinical manifestation, serogroups, phylogenetic groups, and anti…
View article: 2600. Mannose-Binding Lectin Polymorphisms are Important Modulating Factors in Community- and Hospital-Acquired Pneumonia Caused by Legionella spp.
2600. Mannose-Binding Lectin Polymorphisms are Important Modulating Factors in Community- and Hospital-Acquired Pneumonia Caused by Legionella spp. Open
Background Community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) are the leading causes of death from infection in developed countries. Mannose-binding lectin (MBL) is a C-type serum lectin that plays a central role in t…
View article: Molecular Characterisation of Uropathogenic Escherichia coli Reveals Emergence of Drug Resistant O15, O22, and O25 Serogroups
Molecular Characterisation of Uropathogenic Escherichia coli Reveals Emergence of Drug Resistant O15, O22, and O25 Serogroups Open
Background Uropathogenic Escherichia coli (UPEC) are common pathogens causing urinary tract infections (UTIs). We aimed to investigate the relationship among clinical manifestation, serogroups, phylogenetic groups, and antimicrobial resist…
View article: Vaizdo ontologiniai būviai. ikona kaip tikrovės steigimas
Vaizdo ontologiniai būviai. ikona kaip tikrovės steigimas Open
Straipsnyje kalbama apie prezentaciją, reprezentaciją ir simuliaciją kaip vaizdo ontologinius būvius. Šiems būviams įvardyti ir apibūdinti pasitelkiami Christopho Wulfo, Jeano Luco Mariono, Jeano Baudrillardo tekstai. Aptariamas vaizdo ir …