Ruth A Purcell
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View article: Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination Open
Solid tumor malignancy (STM) patients experience increased risk of breakthrough SARS-CoV-2 infection owing to reduced COVID-19 vaccine immunogenicity. However, the underlying immunological causes of impaired neutralization remain poorly ch…
View article: Historic 1994 influenza vaccine cohorts reveal breadth of antibody and B cell responses towards three decades of future influenza A and B viruses
Historic 1994 influenza vaccine cohorts reveal breadth of antibody and B cell responses towards three decades of future influenza A and B viruses Open
Influenza vaccination is the best way to combat annual influenza epidemics, yet the breadth of vaccine-induced humoral immunity towards decades of future differentially-evolving influenza A and B viruses is unclear. Using historic 1994 inf…
View article: Genetic markers of enhanced functional antibody responses to COVID-19 vaccination
Genetic markers of enhanced functional antibody responses to COVID-19 vaccination Open
Primary COVID-19 vaccination induced increased S2-specific IgG in G1m1,17+/+ vaccinees, facilitating enhanced anti-viral FcγR engagement and suggesting immunogenetics may be a valuble consideration for next-generation vaccine de…
View article: Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination Open
Solid tumor malignancy (STM) patients experience increased risk of breakthrough SARS-CoV-2 infection owing to reduced COVID-19 vaccine immunogenicity. However, the underlying immunological causes of impaired neutralization remain poorly ch…
View article: Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant Open
Repeated mRNA COVID-19 vaccination increases spike-specific immunoglobulin G4 (IgG4) titers. Here, we characterized the influence of increased IgG4 titers on a range of Fc-mediated responses. Elevated spike-specific IgG4 reduced binding to…
View article: Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination
Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination Open
Objectives Bacille Calmette–Guérin (BCG) vaccination has off‐target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune …
View article: Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents
Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents Open
Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti‐Ig detection reagents, consequently confounding interpretation of antibody responses, pa…
View article: Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections
Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections Open
Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plasma antib…
View article: Mucosal antibody responses following Vaxzevria vaccination
Mucosal antibody responses following Vaxzevria vaccination Open
Mucosal antibodies play a key role in protection against breakthrough COVID‐19 infections and emerging viral variants. Intramuscular adenovirus‐based vaccination (Vaxzevria) only weakly induces nasal IgG and IgA responses, unless vaccinees…
View article: Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants
Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants Open
View article: Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations
Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations Open
Vaccine efficacy determined within the controlled environment of a clinical trial is usually substantially greater than real-world vaccine effectiveness. Typically, this results from reduced protection of immunologically vulnerable populat…
View article: Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities Open
View article: Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough
Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough Open
Summary Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plas…
View article: Altered affinity to ACE2 and reduced Fc functional antibodies to SARS-CoV-2 RBD variants
Altered affinity to ACE2 and reduced Fc functional antibodies to SARS-CoV-2 RBD variants Open
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants remains a formidable challenge to worldwide public health. The receptor binding domain (RBD) of the SARS-CoV-2 spike protein is a hotspot for mutations,…