Ruth Arnon
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View article: Repurposing of Glatiramer Acetate to Treat Heart Diseases
Repurposing of Glatiramer Acetate to Treat Heart Diseases Open
Myocardial injury may ultimately lead to adverse ventricular remodeling and development of heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the slow pace and substantial costs of developing new therape…
Amyloid Precursor Protein and Tau Peptides Linked Together Ameliorate Loss of Cognition in an Alzheimer’s Disease Animal Model Open
The major proteins involved in Alzheimer’s disease (AD) are amyloid precursor protein (APP) and Tau. We demonstrate that APP1 (390–412) and Tau1 (19–34), linked together with either a flexible or a rigid peptide bridge, are able to inhibit…
View article: Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis
Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis Open
Axonal and neuronal pathologies are a central constituent of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), induced by the myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. In this stu…
Astrocytes in Multiple Sclerosis—Essential Constituents with Diverse Multifaceted Functions Open
In multiple sclerosis (MS), astrocytes respond to the inflammatory stimulation with an early robust process of morphological, transcriptional, biochemical, and functional remodeling. Recent studies utilizing novel technologies in samples f…
Peptide Interference with APP and Tau Association: Relevance to Alzheimer’s Disease Amelioration Open
The two major proteins involved in Alzheimer’s disease (AD) are the amyloid precursor protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other. Four possible peptides APP1 (390–412), APP2 (713–730), Tau1 (…
View article: Cognitive impairment in an animal model of multiple sclerosis and its amelioration by glatiramer acetate
Cognitive impairment in an animal model of multiple sclerosis and its amelioration by glatiramer acetate Open
The severe motor impairment in the MS animal model experimental autoimmune encephalomyelitis (EAE) obstructs the assessment of cognitive functions. We developed an experimental system that evaluates memory faculties in EAE-affected mice, i…
<span>A</span>strocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis Open
To elucidate mechanisms contributing to cortical pathology in multiple sclerosis (MS), we investigated neurovascular aberrations, in particular the association of astrocytes with cortical neurons and blood vessels, in mice induced with exp…
View article: Can remyelination be enhanced by immunomodulatory therapeutic modality?
Can remyelination be enhanced by immunomodulatory therapeutic modality? Open
An essential challenge for multiple sclerosis (MS) therapy is not only to ameliorate the inflammatory aspect of the disease, but to promote repair and remyelination. Glatiramer acetate (GA, Copaxone), an approved MS treatment, has been sho…
View article: Ephraim Katchalski-Katzir. 16 May 1916 — 30 May 2009
Ephraim Katchalski-Katzir. 16 May 1916 — 30 May 2009 Open
Ephraim Katchalski-Katzir was a leading researcher in the development of polyamino acids, which allowed new insights into the reactions and behaviour of proteins. His work developed pathways into the exploration and investigation of antige…
Astrocyte morphology is confined by cortical functional boundaries in mammals ranging from mice to human Open
Cortical blood flow can be modulated by local activity across a range of species; from barrel-specific blood flow in the rodent somatosensory cortex to the human cortex, where BOLD-fMRI reveals numerous functional borders. However, it appe…
Author response: Astrocyte morphology is confined by cortical functional boundaries in mammals ranging from mice to human Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Cortical blood flow can be modul…