Ruth E. Carmichael
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View article: Peroxisome dynamics and inter-organelle interactions in neuronal health and disease
Peroxisome dynamics and inter-organelle interactions in neuronal health and disease Open
Peroxisomes are essential organelles, present in all nucleated cells, with key roles in lipid and redox homeostasis. They are important for maintaining healthy cell function, with defects in peroxisome biogenesis and/or metabolism leading …
View article: Seventy years of peroxisome research: current advances and future perspectives
Seventy years of peroxisome research: current advances and future perspectives Open
sponsorship: We thank the University of Bochum, Springer Nature and Spirochrome AG for their support of this meeting. We also thank the members of the organising team, Meike Jade, Bernhild Erdmann, Samantha Jeng, Tomasz Jeziorek (Ruhr Univ…
View article: The peroxisome: an update on mysteries 3.0
The peroxisome: an update on mysteries 3.0 Open
Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in cellular lipid metabolism, such as the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as the regulation of cellular redox b…
View article: Organelle Membrane Extensions in Mammalian Cells
Organelle Membrane Extensions in Mammalian Cells Open
Organelles within eukaryotic cells are not isolated static compartments, instead being morphologically diverse and highly dynamic in order to respond to cellular needs and carry out their diverse and cooperative functions. One phenomenon e…
View article: First person – Tina Angelika Schrader and Ruth Carmichael
First person – Tina Angelika Schrader and Ruth Carmichael Open
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Tina Angelika Schrader and Ruth Carmic…
View article: Fission Impossible (?)—New Insights into Disorders of Peroxisome Dynamics
Fission Impossible (?)—New Insights into Disorders of Peroxisome Dynamics Open
Peroxisomes are highly dynamic and responsive organelles, which can adjust their morphology, number, intracellular position, and metabolic functions according to cellular needs. Peroxisome multiplication in mammalian cells involves the con…
View article: PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor
PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor Open
Peroxisome membrane dynamics and division are essential to adapt the peroxisomal compartment to cellular needs. The peroxisomal membrane protein PEX11β (also known as PEX11B) and the tail-anchored adaptor proteins FIS1 (mitochondrial fissi…
View article: Determinants of Peroxisome Membrane Dynamics
Determinants of Peroxisome Membrane Dynamics Open
Organelles within the cell are highly dynamic entities, requiring dramatic morphological changes to support their function and maintenance. As a result, organelle membranes are also highly dynamic, adapting to a range of topologies as the …
View article: The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1 Open
Mitochondria are unavoidably subject to organellar stress resulting from exposure to a range of reactive molecular species. Consequently, cells operate a poorly understood quality control programme of mitophagy to facilitate elimination of…
View article: Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2 Open
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated p…
View article: A Functional SMAD2/3 Binding Site in the PEX11β Promoter Identifies a Role for TGFβ in Peroxisome Proliferation in Humans
A Functional SMAD2/3 Binding Site in the PEX11β Promoter Identifies a Role for TGFβ in Peroxisome Proliferation in Humans Open
In mammals, peroxisomes perform crucial functions in cellular metabolism, signaling and viral defense which are essential to the viability of the organism. Molecular cues triggered by changes in the cellular environment induce a dynamic re…
View article: Maintaining social contacts: The physiological relevance of organelle interactions
Maintaining social contacts: The physiological relevance of organelle interactions Open
Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed "membrane contact sites" (MCSs), represents an intriguing strategy for organ…
View article: Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2 Open
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated p…
View article: Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation
Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation Open
Peroxisomes are highly dynamic subcellular compartments with important functions in lipid and ROS metabolism. Impaired peroxisomal function can lead to severe metabolic disorders with developmental defects and neurological abnormalities. R…
View article: The SUMO Protease SENP3 regulates Mitochondrial Autophagy mediated by Fis1
The SUMO Protease SENP3 regulates Mitochondrial Autophagy mediated by Fis1 Open
Mitochondria are unavoidably subject to organellar stress resulting from exposure to a range of reactive molecular species. Consequently, cells operate a poorly understood quality control programme of mitophagy to facilitate elimination of…