Ruth E. McDowell
YOU?
Author Swipe
View article: Metabolic blockade of glycolysis diminishes autoreactive CD4 T cell differentiation in Type 1 diabetes 4521
Metabolic blockade of glycolysis diminishes autoreactive CD4 T cell differentiation in Type 1 diabetes 4521 Open
Description Type 1 diabetes (T1D) is a result of pancreatic β-cell destruction by autoreactive T cells. Proinflammatory Th1 CD4 T cells prefer glycolysis for maintaining effector responses. We hypothesize that metabolic inhibition of glyco…
View article: GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion Open
Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act as cellular signals to regulate pancreatic β-cell fun…
View article: GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion Open
Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act as cellular signals to regulate pancreatic β-cell fun…
View article: GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion Open
Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act as cellular signals to regulate pancreatic β-cell fun…
View article: Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation
Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation Open
The inflammatory response is an obstacle to success in both allogeneic and autologous islet transplantation. In autologous islet transplantation (AIT), however, the recipient is also the donor, permitting pretreatment of donor/recipient fo…
View article: IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes
IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes Open
View article: Platelet glycolytic metabolism correlates with hemodynamic severity in pulmonary arterial hypertension
Platelet glycolytic metabolism correlates with hemodynamic severity in pulmonary arterial hypertension Open
Group 1 pulmonary hypertension (PH), i.e., pulmonary arterial hypertension (PAH), is associated with a metabolic shift favoring glycolysis in cells comprising the lung vasculature as well as skeletal muscle and right heart. We sought to de…
View article: Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance
Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance Open
The current study reveals a HFD-ART interaction that increases inflammatory transcriptional pathways and impairs glucose metabolism, energy balance, and metabolic dysfunction.