Ruth E. Trevaks
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View article: Effect of Aspirin on Development of First and Recurrent Primary Cutaneous Keratinocyte Carcinomas in Older Australian Adults: Extended Follow-up of a Large Randomised Controlled Trial
Effect of Aspirin on Development of First and Recurrent Primary Cutaneous Keratinocyte Carcinomas in Older Australian Adults: Extended Follow-up of a Large Randomised Controlled Trial Open
Keratinocyte carcinomas (KC) are the most frequent cancers diagnosed in Australia and impart the largest economic cost of all cancers. Predisposed individuals tend to develop multiple KC over their lifetime. Data from the ASPirin in Reduci…
View article: The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults
The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults Open
Background Retinal vessel calibres (RVCs) are non-invasive markers of microvascular health and may serve as accessible indicators of cerebral small vessel disease (CSVD) and future cognitive impairment. This study examines whether RVCs are…
View article: Obstructive sleep apnea and cerebral small vessel disease in community-based older people: an aspirin in reducing events in the elderly imaging substudy
Obstructive sleep apnea and cerebral small vessel disease in community-based older people: an aspirin in reducing events in the elderly imaging substudy Open
Study Objectives Obstructive sleep apnea (OSA) may increase the risk of dementia. A potential pathway for this risk is through cerebral small vessel disease (CSVD). In the context of an existing randomized trial of aspirin for primary prev…
View article: Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy
Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy Open
Importance Obstructive sleep apnoea (OSA) may increase the risk of dementia; however, studies have reported variable findings. We investigated if undiagnosed OSA in healthy older adults is associated with cognitive decline, and whether low…
View article: Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration
Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration Open
Importance Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in old age. There is no proven intervention to prevent AMD and, apart from lifestyle, nutritional, and supplement advice, there is no interv…
View article: The association between sex hormones and the change in brain‐predicted age difference in older women
The association between sex hormones and the change in brain‐predicted age difference in older women Open
Objective The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating sex hormones in older women are associated with the baseline and longitudinal cha…
View article: Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function
Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function Open
Introduction Neuroimaging-based ‘brain age’ can identify individuals with ‘advanced’ or ‘resilient’ brain aging. Brain-predicted age difference (brain-PAD) is predictive of cognitive and physical health outcomes. However, it is unknown how…
View article: Sleep‐disordered breathing was associated with lower health‐related quality of life and cognitive function in a cross‐sectional study of older adults
Sleep‐disordered breathing was associated with lower health‐related quality of life and cognitive function in a cross‐sectional study of older adults Open
Background and objective The clinical significance of sleep‐disordered breathing (SDB) in older age is uncertain. This study determined the prevalence and associations of SDB with mood, daytime sleepiness, quality of life (QOL) and cogniti…
View article: Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals
Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals Open
Background: There is considerable variability in the rate at which we age biologically, and the brain is particularly susceptible to the effects of aging. Objective: We examined the test-retest reliability of brain age at one- and three-ye…
View article: The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study
The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study Open
Background Frailty is associated with chronic inflammation, which may be modified by aspirin. The purpose of this study was to determine whether low-dose aspirin reduces incident frailty in healthy older adult participants of the ASPirin i…
View article: 1195Brain-predicted age difference is associated with cognitive processing and delayed recall in later life
1195Brain-predicted age difference is associated with cognitive processing and delayed recall in later life Open
Background Brain age is a novel neuroimaging-based marker of ageing that uses machine learning to predict a person’s biological brain age. A higher brain age relative to chronological age (i.e., brain-predicted age difference [brain-PAD]) …
View article: Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults
Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults Open
Background Cerebrovascular events, dementia, and cancer can contribute to physical disability with activities of daily living (ADL). It is unclear whether low-dose aspirin reduces this burden in aging populations. In a secondary analysis, …
View article: Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos
Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos Open
Background: Processing speed, which can be assessed using the Symbol Digit Modalities Test (SDMT), is central to many brain functions. Processing speed declines with advanced age but substantial impairments are indicative of brain injury o…
View article: Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals
Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals Open
Objectives: The AHA/ACC-2017 hypertension guideline recommends an age-independent target blood pressure (BP) of less than 130/80 mmHg. In an elderly cohort without established cardiovascular disease (CVD) at baseline, we determined the imp…
View article: Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline
Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline Open
NCT01038583.
View article: Normative performance of older individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) according to ethno-racial group, gender, age and education level
Normative performance of older individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) according to ethno-racial group, gender, age and education level Open
Ethno-racial, age, gender and education-stratified normative data from this large cohort of community-dwelling older individuals will serve as important reference standards in Australia and the U.S. to assess cognition in older individuals.
View article: Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study
Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study Open
BACKGROUND Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in the understanding of the management of high BP in the aged. We explored antihypertensive t…
View article: Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study
Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study Open
This is a correction to:
\nThe Journals of Gerontology: Series A, Volume 72, Issue 11, November 2017, Pages 1586–1593, https://doi.org/10.1093/gerona/glw342
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\nIn the article “Baseline Characteristics of Participants in the ASPREE (ASPi…
View article: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly Open
The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo. (Funded by th…
View article: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly Open
Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer-related death. In the context of previous studies, this r…
View article: Effect of Aspirin on Disability-free Survival in the Healthy Elderly
Effect of Aspirin on Disability-free Survival in the Healthy Elderly Open
Aspirin use in healthy elderly persons did not prolong disability-free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrial…
View article: Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study
Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study Open
Findings from ASPREE will be generalizable to a healthier older population in both countries and will assess whether the broad benefits of daily low-dose aspirin in prolonging independent life outweigh the risks.