Ruth M. Hall
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View article: The <i>aphA1</i> kanamycin and neomycin resistance gene originated in <i>Klebsiella michiganensis</i>
The <i>aphA1</i> kanamycin and neomycin resistance gene originated in <i>Klebsiella michiganensis</i> Open
Background The origins of several antibiotic resistance genes have been traced to intrinsic genes present in bacterial chromosomes. The aphA1 gene, which confers resistance to the aminoglycosides kanamycin and neomycin, is commonly found i…
View article: Structure of the K49 capsular polysaccharide produced by the Acinetobacter baumannii ST10 carriage isolate, NL6
Structure of the K49 capsular polysaccharide produced by the Acinetobacter baumannii ST10 carriage isolate, NL6 Open
The K49 capsular polysaccharide (CPS) produced by the Acinetobacter baumannii ST10 carriage isolate, NL6, that carries KL49 at the CPS biosynthesis K locus, was studied by sugar analysis along with one- and two-dimensional 1H and 13C NMR s…
View article: Carbapenem-resistant Acinetobacter baumannii isolate BAL114 from Vietnam produces capsular polysaccharide with two forms of the K58 unit
Carbapenem-resistant Acinetobacter baumannii isolate BAL114 from Vietnam produces capsular polysaccharide with two forms of the K58 unit Open
Capsular polysaccharide (CPS) produced by two Acinetobacter baumannii isolates carrying the KL58 locus were recently determined and found to differ due to the presence of additional CPS biosynthesis genes found in prophage. Here, we have e…
View article: Genomic characteristics of the multiresistant <i>Acinetobacter baumannii</i> global clone 1 reference strain A297/RUH875
Genomic characteristics of the multiresistant <i>Acinetobacter baumannii</i> global clone 1 reference strain A297/RUH875 Open
Objectives Acinetobacter baumannii ST1, also known as global clone 1 (GC1), is a globally distributed lineage associated with antimicrobial resistance (AMR). The multiresistant isolate A297/RUH8751, recovered from a urinary tract infection…
View article: Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii
Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii Open
The multiply antibiotic-resistant lineage 1 of Acinetobacter baumannii global clone 1 (GC1) emerged in the 1970s, and subsequently more extensively resistant sublineages have emerged. Here, we examined the evolution of the extensively resi…
View article: SGI1 excludes IncA and IncC plasmids
SGI1 excludes IncA and IncC plasmids Open
SGI1 and its many variant forms are integrative mobilizable elements that rely on IncA or IncC plasmids for transfer functions. However, the coexistence of SGI1 with the plasmid is unstable in the longer term. Here, we have investigated th…
View article: Structure of the K58 capsular polysaccharide produced by Acinetobacter baumannii isolate MRSN 31468 includes Pse5Ac7Ac that is 4-O-acetylated by a phage-encoded acetyltransferase
Structure of the K58 capsular polysaccharide produced by Acinetobacter baumannii isolate MRSN 31468 includes Pse5Ac7Ac that is 4-O-acetylated by a phage-encoded acetyltransferase Open
Capsular polysaccharide (CPS), a heteropolymeric carbohydrate structure present on the cell surface of most isolates of the bacterial pathogen Acinetobacter baumannii, is a major virulence determinant. Here, the CPS produced by A. baumanni…
View article: An <i>Acinetobacter baumannii</i> nasal carriage isolate recovered from an asymptomatic patient in Vietnam is extensively antibiotic resistant and produces a rare K71 type capsule
An <i>Acinetobacter baumannii</i> nasal carriage isolate recovered from an asymptomatic patient in Vietnam is extensively antibiotic resistant and produces a rare K71 type capsule Open
Acinetobacter baumannii is a leading cause of multidrug-resistant bacterial infections worldwide, and the capsular polysaccharide (CPS) is a major virulence determinant. A previous study of A. baumannii from intubated and asymptomatic pati…
View article: Characterization of the carbapenem-resistant <i>Acinetobacter baumannii</i> clinical reference isolate BAL062 (CC2:KL58:OCL1): resistance properties and capsular polysaccharide structure
Characterization of the carbapenem-resistant <i>Acinetobacter baumannii</i> clinical reference isolate BAL062 (CC2:KL58:OCL1): resistance properties and capsular polysaccharide structure Open
The carbapenem-resistant Acinetobacter baumannii isolate BAL062 is a clinical reference isolate used in several recent experimental studies. It is from a ventilator-associated pneumonia (VAP) patient in an intensive care unit at the Hospit…
View article: A programmable seekRNA guides target selection by IS1111 and IS110 type insertion sequences
A programmable seekRNA guides target selection by IS1111 and IS110 type insertion sequences Open
IS 1111 and IS 110 insertion sequence (IS) family members encode an unusual DEDD transposase type and exhibit specific target site selection. The IS 1111 group include identifiable subterminal inverted repeats (sTIR) not found in the IS 11…
View article: Distribution and expression of the <i>aac</i>(6′)-<i>Im</i> (<i>aacA16</i>) aminoglycoside resistance gene
Distribution and expression of the <i>aac</i>(6′)-<i>Im</i> (<i>aacA16</i>) aminoglycoside resistance gene Open
Background The aac(6′)-Im (aacA16) amikacin, netilmicin and tobramycin resistance gene cassette had been circulating globally undetected for many years in a sublineage of Acinetobacter baumannii global clone 2. Objectives To identify sourc…
View article: Characterisation of the carbapenem-resistant<i>Acinetobacter baumannii</i>clinical reference isolate BAL062 (CC2:KL58:OCL1): resistance properties and capsular polysaccharide structure
Characterisation of the carbapenem-resistant<i>Acinetobacter baumannii</i>clinical reference isolate BAL062 (CC2:KL58:OCL1): resistance properties and capsular polysaccharide structure Open
The carbapenem resistant Acinetobacter baumannii isolate BAL062 is a clinical reference isolate used in several recent experimental studies. It is from a ventilator associated pneumonia (VAP) patient in an intensive care unit at the Hospit…
View article: A programmable seeker RNA guides target selection by IS<i>1111</i>and IS<i>110</i>type insertion sequences
A programmable seeker RNA guides target selection by IS<i>1111</i>and IS<i>110</i>type insertion sequences Open
SUMMARY IS 1111 and IS 110 insertion sequence (IS) family members encode an unusual DEDD transposase type and exhibit specific target site selection. The IS 1111 group include identifiable subterminal inverted repeats (sTIR) not found in t…
View article: Aminoglycoside resistance genes in early members of the <i>Acinetobacter baumannii</i> ST78A (SMAL, Italian clone) reside in an IS<i>26</i>-bounded island in the chromosome
Aminoglycoside resistance genes in early members of the <i>Acinetobacter baumannii</i> ST78A (SMAL, Italian clone) reside in an IS<i>26</i>-bounded island in the chromosome Open
Background The Acinetobacter baumannii isolate called SMAL, previously used to determine the structures of capsular polysaccharide and lipooligosaccharide, was recovered in Pavia, Italy in 2002 among the collection of aminoglycoside-resist…
View article: IS <i>26</i> and the IS <i>26</i> family: versatile resistance gene movers and genome reorganizers
IS <i>26</i> and the IS <i>26</i> family: versatile resistance gene movers and genome reorganizers Open
SUMMARY In Gram-negative bacteria, the insertion sequence IS 26 is highly active in disseminating antibiotic resistance genes. IS 26 can recruit a gene or group of genes into the mobile gene pool and support their continued dissemination t…
View article: Variation in the plasmid backbone and dif module content of R3-T33 Acinetobacter plasmids
Variation in the plasmid backbone and dif module content of R3-T33 Acinetobacter plasmids Open
The predominant type of plasmids found in Acinetobacter species encode a Rep_3 initiation protein and many of these carry their accessory genes in dif modules. Here, available sequences of the 14 members of the group of Rep_3 plasmids type…
View article: Using Population Segmentation to Identify Opportunities for Integrated Care in Ontario, Canada.
Using Population Segmentation to Identify Opportunities for Integrated Care in Ontario, Canada. Open
Ontario, Canada has introduced Ontario Health Teams (OHTs) to advance integrated care and population health management. There are currently 54 OHTs covering a population of nearly 14 Million individuals. The teams are expected to plan and …
View article: Revised structure of the polysaccharide from Acinetobacter baumannii LUH5551 assigned as the K63 type capsular polysaccharide
Revised structure of the polysaccharide from Acinetobacter baumannii LUH5551 assigned as the K63 type capsular polysaccharide Open
K63 capsular polysaccharide produced by Acinetobacter baumannii isolate LUH5551 (previously designated isolate O24) was re-examined using sugar analysis, Smith degradation, and one- and two-dimensional 1H and 13C NMR spectroscopy. Though p…
View article: The <i>Acinetobacter baumannii</i> K70 and K9 capsular polysaccharides consist of related K-units linked by the same Wzy polymerase and cleaved by the same phage depolymerases
The <i>Acinetobacter baumannii</i> K70 and K9 capsular polysaccharides consist of related K-units linked by the same Wzy polymerase and cleaved by the same phage depolymerases Open
The extensively antibiotic-resistant Acinetobacter baumannii GC1(ST1 IP ) isolate SGH0807 from Singapore carries the KL70 gene cluster. The structure of the K70 capsular polysaccharide (CPS) produced by SGH0807 was determined using sugar a…
View article: The extensively antibiotic resistant ST111 Acinetobacter baumannii isolate RBH2 carries an extensive mobile element complement of plasmids, transposons and insertion sequences
The extensively antibiotic resistant ST111 Acinetobacter baumannii isolate RBH2 carries an extensive mobile element complement of plasmids, transposons and insertion sequences Open
The complete genome of RBH2, a sporadic, carbapenem resistant ST111 Acinetobacter baumannii isolate from Brisbane, Australia was determined and analysed. RBH2 is extensively resistant and the chromosome includes two transposons carrying an…
View article: Acinetobacter baumannii GC2 Sublineage Carrying the <i>aac</i> ( <i>6</i> ′)- <i>Im</i> Amikacin, Netilmicin, and Tobramycin Resistance Gene Cassette
Acinetobacter baumannii GC2 Sublineage Carrying the <i>aac</i> ( <i>6</i> ′)- <i>Im</i> Amikacin, Netilmicin, and Tobramycin Resistance Gene Cassette Open
Aminoglycosides are important therapeutic options for treatment of Acinetobacter infections. Here, we show that a little-known aminoglycoside resistance gene, aac(6′)-Im ( aacA16 ), that confers amikacin, netilmicin, and tobramycin resista…
View article: The RuvABC Holliday Junction Processing System Is Not Required for IS <i>26</i> -Mediated Targeted Conservative Cointegrate Formation
The RuvABC Holliday Junction Processing System Is Not Required for IS <i>26</i> -Mediated Targeted Conservative Cointegrate Formation Open
In Gram-negative bacteria, the contribution of IS 26 to the spread of antibiotic resistance and other genes that provide cells with an advantage under specific conditions far exceeds that of any other known insertion sequence. This is like…
View article: Characterisation of an early South African multiply antibiotic-resistant global clone 1 Acinetobacter baumannii isolate
Characterisation of an early South African multiply antibiotic-resistant global clone 1 Acinetobacter baumannii isolate Open
LUH6050 represents an early form of the GC1 lineage 1, supplementing limited information about early isolates and isolates from Africa. These data contribute to the understanding of the emergence, evolution, and dissemination of the A. bau…
View article: Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities
Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities Open
A. baumannii is recognized as one of the most important nosocomial pathogens, and carbapenem-resistant strains pose a particularly difficult treatment challenge. Outbreaks linked to this pathogen are reported worldwide, particularly during…
View article: Insertion sequences related to ISAjo2 target pdif and dif sites and belong to a new IS family, the IS1202 family
Insertion sequences related to ISAjo2 target pdif and dif sites and belong to a new IS family, the IS1202 family Open
Several insertion sequences (IS) found in various Acinetobacter species exhibit target specificity. They are found, in the same orientation, 5 bp from the XerC binding site of the p dif sites associated with dif modules in Acinetobacter pl…
View article: Loss of a Branch Sugar in the Acinetobacter baumannii K3-Type Capsular Polysaccharide Due To Frameshifts in the <i>gtr6</i> Glycosyltransferase Gene Leads To Susceptibility To Phage APK37.1
Loss of a Branch Sugar in the Acinetobacter baumannii K3-Type Capsular Polysaccharide Due To Frameshifts in the <i>gtr6</i> Glycosyltransferase Gene Leads To Susceptibility To Phage APK37.1 Open
Lytic bacteriophage have potential for the treatment of otherwise untreatable extensively antibiotic-resistant bacteria. For Acinetobacter baumannii , most phage exhibit specificity for the type of capsular polysaccharide (CPS) produced on…
View article: The <i>Acinetobacter baumannii</i> website (Ab-web): a multidisciplinary knowledge hub, communication platform, and workspace
The <i>Acinetobacter baumannii</i> website (Ab-web): a multidisciplinary knowledge hub, communication platform, and workspace Open
Acinetobacter baumannii is a Gram-negative bacterium increasingly implicated in hospital-acquired infections and outbreaks. Effective prevention and control of such infections are commonly challenged by the frequent emergence of multidrug-…