R.L. McDonald
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View article: A role for the volume regulated anion channel in volume regulation in the murine CNS cell line, CAD
A role for the volume regulated anion channel in volume regulation in the murine CNS cell line, CAD Open
Aim: The role of the volume regulated anion channel (VRAC) in a model CNS neuronal cell line, CAD, was investigated. Methods: Changes in cell volume following hypotonic challenges were measured using a video‐imaging technique. The effect o…
View article: Quantitative analysis of Na<sup>+</sup>‐Ca<sup>2+</sup> exchanger expression in guinea‐pig heart
Quantitative analysis of Na<sup>+</sup>‐Ca<sup>2+</sup> exchanger expression in guinea‐pig heart Open
In previous studies, regional variations in the expression of the Na + ‐Ca 2+ exchanger (NCX) have been examined qualitatively in human heart using the C2C12 monoclonal antibody [Wang, J., Schwinger, R.H., Frank, K., Muller‐Ehmsen, J., Mar…
View article: Block of human aorta Kir6.1 by the vascular K<sub>ATP</sub> channel inhibitor U37883A
Block of human aorta Kir6.1 by the vascular K<sub>ATP</sub> channel inhibitor U37883A Open
A human aorta cDNA library was screened at low stringency with a rat pancreatic Kir6.1 cDNA probe and a homologue of Kir6.1 (hKir6.1) was isolated and sequenced. Metabolic poisoning of Xenopus laevis oocytes with sodium azide and applicati…
View article: Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y<sub>2</sub> receptor
Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y<sub>2</sub> receptor Open
In order to stabilize the C‐terminal dodecapeptide of neuropeptide Y (NPY) we replaced Leu 28 and Thr 32 by Lys and Glu, respectively, and subsequently linked these residues by lactamization. This peptide analog of NPY shows a more than 10…
View article: Muscarinic (Mi) receptor‐mediated inhibition of K<sup>+</sup>‐evoked [<sup>3</sup>H]‐noradrenaline release from human neuroblastoma (SH‐SY5Y) cells via inhibition of L‐ and N‐type Ca<sup>2+</sup> channels
Muscarinic (Mi) receptor‐mediated inhibition of K<sup>+</sup>‐evoked [<sup>3</sup>H]‐noradrenaline release from human neuroblastoma (SH‐SY5Y) cells via inhibition of L‐ and N‐type Ca<sup>2+</sup> channels Open
1. Human neuroblastoma (SH-SY5Y) cells were preincubated with [3H]-noradrenaline ([3H]-NA) in the presence of 0.2 mM pargyline to examine the modulation of K(+)-evoked [3H]-NA release by muscarinic agonists. 2. Release of [3H]-NA evoked by…