Explanipedia

Recent Systemic Antifungal Exposure and Nonsusceptible Candida in Hospitalized Patients, South Africa, 2012–2017 Open

Charlotte Rabault, Liliwe Shuping, Ruth Mpembe, Vanessa Quan, Fanny Lanternier , et al. · 2025

Candida bloodstream infections, and their increasing antifungal resistance, are a global concern. In this cross-sectional study, we analyzed 2,443 culture-confirmed candidemia cases reported in South Africa during 2012-2017 to assess the e…

High Prevalence of Candida auris Colonization during Protracted Neonatal Unit Outbreak, South Africa Open

Liliwe Shuping, Tsidiso G. Maphanga, Serisha D. Naicker, Ruth Mpembe, Nqobile Ngoma , et al. · 2023

One third of patients were colonized by Candida auris during a point-prevalence survey in a neonatal unit during an outbreak in South Africa. The sensitivity of a direct PCR for rapid colonization detection was 44% compared with culture. T…

In Vitro Antifungal Activity of Manogepix and Other Antifungal Agents against South African Candida auris Isolates from Bloodstream Infections Open

Tsidiso G. Maphanga, Ruth Mpembe, Serisha D. Naicker, Nelesh P. Govender · 2022

Since C. auris was first detected in South Africa in 2009, health care-associated transmission events and large outbreaks have led to this pathogen accounting for more than 1 in 10 cases of candidemia. A large proportion of South African C…

In Vitro Antifungal Resistance of Candida auris Isolates from Bloodstream Infections, South Africa Open

Tsidiso G. Maphanga, Serisha D. Naicker, Stanford Kwenda, José F. Muñoz, Erika van Schalkwyk , et al. · 2021

Candida auris is a multidrug-resistant fungal pathogen that is endemic in South African hospitals. We tested bloodstream C. auris isolates that were submitted to a reference laboratory for national laboratory-based surveillance for candide…

An outbreak of cutaneous abscesses caused by Panton-Valentine leukocidin-producing methicillin-susceptible Staphylococcus aureus among gold mine workers, South Africa, November 2017 to March 2018 Open

Husna Ismail, Nelesh P. Govender, Ashika Singh-Moodley, Erika van Schalkwyk, Liliwe Shuping , et al. · 2020

Background We aimed to describe an outbreak of cutaneous abscesses caused by Panton-Valentine leukocidin (PVL)-producing methicillin-susceptible Staphylococcus aureus (MSSA) among gold mine workers. Methods In February 2018, we retrospecti…

Decreasing fluconazole susceptibility of clinical South African Cryptococcus neoformans isolates over a decade Open

Serisha D. Naicker, Ruth Mpembe, Tsidiso G. Maphanga, Thokozile G. Zulu, Daniel DeSanto , et al. · 2020

Fluconazole MIC50 and MIC90 values were two-fold higher in 2017 compared to 2007-2008. Although there are no breakpoints, higher fluconazole doses may be required to maintain efficacy of standard treatment regimens for cryptococcal meningi…

Human Blastomycosis in South Africa Caused byBlastomyces percursusandBlastomyces emzantsisp. nov., 1967 to 2014 Open

Tsidiso G. Maphanga, Monica Birkhead, José F. Muñoz, Mushal Allam, Thokozile G. Zulu , et al. · 2020

We reevaluated 20 cases of blastomycosis diagnosed in South Africa between 1967 and 2014, with Blastomyces dermatitidis considered to be the etiological agent, in light of newly described species and the use of more advanced technologies. …

Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016–20171 Open

Erika van Schalkwyk, Ruth Mpembe, Juno Thomas, Liliwe Shuping, Husna Ismail , et al. · 2019

Candida auris is an invasive healthcare-associated fungal pathogen. Cases of candidemia, defined as illness in patients with Candida cultured from blood, were detected through national laboratory-based surveillance in South Africa during 2…

Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016–20171 Open

Erika van Schalkwyk, Ruth Mpembe, Juno Thomas, Liliwe Shuping, Husna Ismail , et al. · 2019

Candida auris is an invasive healthcare-associated fungal pathogen. Cases of candidemia, defined as illness in patients with Candida cultured from blood, were detected through national laboratory-based surveillance in South Africa during 2…

Candida aurisin South Africa, 2012–2016 Open

Nelesh P. Govender, Rindidzani E. Magobo, Ruth Mpembe, Mabatho Mhlanga, Phelly Matlapeng , et al. · 2018

To determine the epidemiology of Candida auris in South Africa, we reviewed data from public- and private-sector diagnostic laboratories that reported confirmed and probable cases of invasive disease and colonization for October 2012-Novem…

Candida aurisin South Africa, 2012–2016 Open

Nelesh P. Govender, Rindidzani E. Magobo, Ruth Mpembe, Mabatho Mhlanga, Phelly Matlapeng , et al. · 2018

To determine the epidemiology of Candida auris in South Africa, we reviewed data from public- and private-sector diagnostic laboratories that reported confirmed and probable cases of invasive disease and colonization for October 2012–Novem…

Large Outbreaks of Fungal and Bacterial Bloodstream Infections in a Neonatal Unit, South Africa, 2012–2016 Open

Erika van Schalkwyk, Samantha Iyaloo, Serisha D. Naicker, Tsidiso G. Maphanga, Ruth Mpembe , et al. · 2018

Candidemia is a major cause of healthcare-associated infections. We describe a large outbreak of Candida krusei bloodstream infections among infants in Gauteng Province, South Africa, during a 4-month period; a series of candidemia and bac…

In Vitro Antifungal Susceptibility of Yeast and Mold Phases of Isolates of Dimorphic Fungal Pathogen Emergomycesafricanus (Formerly Emmonsia sp.) from HIV-Infected South African Patients Open

Tsidiso G. Maphanga, Erika Britz, Thokozile G. Zulu, Ruth Mpembe, Serisha D. Naicker , et al. · 2017

Disseminated emmonsiosis is an important AIDS-related mycosis in South Africa that is caused by Emergomyces africanus , a newly described and renamed dimorphic fungal pathogen. In vitro antifungal susceptibility data can guide management. …

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