Ruth Namazzi
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View article: Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality
Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality Open
View article: Low prevalence of helminth infection in Ugandan children hospitalized with severe malaria
Low prevalence of helminth infection in Ugandan children hospitalized with severe malaria Open
Co-infection by intestinal helminths and Plasmodium spp. may be common in endemic communities. In 2003, Uganda instituted a national deworming program, with anti-helminth medication provided twice annually to children 6 months to 5 years o…
View article: Acute soft head syndrome and orbital compression syndrome in a child with sickle cell disease: a case report
Acute soft head syndrome and orbital compression syndrome in a child with sickle cell disease: a case report Open
View article: Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria
Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria Open
View article: The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial
The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial Open
Pharmacokinetic (PK)‐guided dosing of hydroxyurea for children with sickle cell anaemia (SCA) could optimize dosing and improve outcomes, but its feasibility has not been demonstrated in low‐resource settings where the majority of affected…
View article: clinical characteristsics of adolescents and adults with sickle cell disease and barriers to transition to adult care at Mulago Hospital Uganda; A mixed methods study
clinical characteristsics of adolescents and adults with sickle cell disease and barriers to transition to adult care at Mulago Hospital Uganda; A mixed methods study Open
View article: Natural killer cell function in children with severe malaria differs according to malaria transmission intensity
Natural killer cell function in children with severe malaria differs according to malaria transmission intensity Open
Memory-like Natural Killer (NK) cells with enhanced antibody-dependent cellular cytotoxicity (ADCC) have correlated with protection from uncomplicated malaria in prior studies. However, the role of NK cells in severe malaria (SM) has not b…
View article: The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial
The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial Open
Pharmacokinetic (PK)‐guided dosing of hydroxyurea for children with sickle cell anaemia (SCA) could optimize dosing and improve outcomes, but its feasibility has not been demonstrated in low‐resource settings where the majority of affected…
View article: Clinical characteristics of adolescents and adults with Sickle Cell Disease and barriers to transition to adult care at Mulago Hospital, Uganda: A mixed methods study
Clinical characteristics of adolescents and adults with Sickle Cell Disease and barriers to transition to adult care at Mulago Hospital, Uganda: A mixed methods study Open
Background Outcome of patients with sickle cell disease (SCD) has improved greatly over the past 60 years with several studies showing improved survival into adulthood due to advancement in medical care. A successful transition is critical…
View article: Neurocognitive gains among Ugandan children with sickle cell anemia on hydroxyurea: 18-month interim trial results
Neurocognitive gains among Ugandan children with sickle cell anemia on hydroxyurea: 18-month interim trial results Open
Children with sickle cell anemia (SCA) frequently develop progressive neurocognitive impairment. We aimed to determine effects of hydroxyurea therapy on neurocognitive function in Ugandan children with SCA by comparing levels at enrollment…
View article: Incident Stroke in Pediatric Sickle cell Anemia Despite Overall Improved Transcranial Doppler Velocity in a Ugandan Hydroxyurea Trial: Antecedent and ongoing risks
Incident Stroke in Pediatric Sickle cell Anemia Despite Overall Improved Transcranial Doppler Velocity in a Ugandan Hydroxyurea Trial: Antecedent and ongoing risks Open
Introduction Transcranial doppler ultrasound (TCD) screening for primary stroke prevention in children with sickle cell anemia (SCA) was established in higher-resource regions, targeting interventions for highest velocity (“abnormal”). We …
View article: Severe falciparum malaria in young children is associated with an increased risk of post-discharge hospitalization: a prospective cohort study
Severe falciparum malaria in young children is associated with an increased risk of post-discharge hospitalization: a prospective cohort study Open
In this malaria endemic region, children with the five most common forms of SM had higher rates of post-discharge hospitalization than asymptomatic community children, and > 80% of hospitalizations were due to severe malaria. Studies of po…
View article: Building capacity for pediatric hematological diseases in Sub-Saharan Africa
Building capacity for pediatric hematological diseases in Sub-Saharan Africa Open
The spectrum of hematological diseases in African children includes anemias, bleeding disorders, thromboses, and oncological diseases such as leukemias. Although data are limited, outcomes for these diseases are poorer in Africa. The deart…
View article: Artemisinin Partial Resistance in Ugandan Children With Complicated Malaria
Artemisinin Partial Resistance in Ugandan Children With Complicated Malaria Open
This study assesses artemisinin partial resistance, Pfkelch13 variations, and malaria recrudescence in Ugandan children with complicated malaria.
View article: Severe falciparum malaria in young children is associated with an increased risk of post-discharge readmission or death: A prospective cohort study
Severe falciparum malaria in young children is associated with an increased risk of post-discharge readmission or death: A prospective cohort study Open
View article: Low prevalence of soil transmitted helminth infection in Ugandan children hospitalized with severe malaria
Low prevalence of soil transmitted helminth infection in Ugandan children hospitalized with severe malaria Open
Co-infection by intestinal helminths and Plasmodium spp. may be common in endemic communities. Several studies have identified a relationship between helminth infection, Plasmodium spp. infection and malaria severity. However, the relation…
View article: Outcomes of pediatric in-hospital cardiac arrest in the emergency department of a tertiary referral hospital in Tanzania: a retrospective cohort study
Outcomes of pediatric in-hospital cardiac arrest in the emergency department of a tertiary referral hospital in Tanzania: a retrospective cohort study Open
View article: PDOC-08 THE CLINICAL CHARACTERISTICS OF CHILDREN WITH CRANIOPHARYNGIOMA AND THEIR MANAGEMENT IN UGANDA: A RETROSPECTIVE REVIEW
PDOC-08 THE CLINICAL CHARACTERISTICS OF CHILDREN WITH CRANIOPHARYNGIOMA AND THEIR MANAGEMENT IN UGANDA: A RETROSPECTIVE REVIEW Open
BACKGROUND Craniopharyngiomas are benign brain tumors that mostly arise in the sellar/suprasellar region. Histologically though benign, these tumors can locally infiltrate with involvement of surrounding structures. They have a 5-year surv…
View article: Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria
Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria Open
Background Recently, there has been an unexplained increase in the incidence of blackwater fever (BWF) in Eastern Uganda. In this study, we evaluated the association between immune complexes, glucose-6-phosphate dehydrogenase (G6PD) defici…
View article: The Ugandan sickle Pan-African research consortium registry: design, development, and lessons
The Ugandan sickle Pan-African research consortium registry: design, development, and lessons Open
Uganda has been able to develop a SCD registry consistent with data from Tanzania, Nigeria and Ghana. Our findings demonstrate that it's feasible to develop longitudinal SCD registries in sub-Saharan Africa. These registries will be crucia…
View article: CP-08. THE CLINICAL CHARACTERISTICS OF CHILDREN WITH CRANIOPHARYNGIOMA AND THEIR MANAGEMENT IN UGANDA: A RETROSPECTIVE REVIEW
CP-08. THE CLINICAL CHARACTERISTICS OF CHILDREN WITH CRANIOPHARYNGIOMA AND THEIR MANAGEMENT IN UGANDA: A RETROSPECTIVE REVIEW Open
BACKGROUND Craniopharyngiomas are benign brain tumors that mostly arise in the sellar/suprasellar region. Histologically though benign, these tumors can locally infiltrate with involvement of surrounding structures. They have a 5-year surv…
View article: Rapid gene fusion testing using the NanoString nCounter platform to improve pediatric leukemia diagnoses in Sub-Saharan Africa
Rapid gene fusion testing using the NanoString nCounter platform to improve pediatric leukemia diagnoses in Sub-Saharan Africa Open
Risk stratification and molecular targeting have been key to increasing cure rates for pediatric cancers in high-income countries. In contrast, precise diagnosis in low-resource settings is hindered by insufficient pathology infrastructure…
View article: Outcomes of in-hospital pediatric cardiac arrest in the emergency department of a tertiary referral hospital in Tanzania: a retrospective cohort study
Outcomes of in-hospital pediatric cardiac arrest in the emergency department of a tertiary referral hospital in Tanzania: a retrospective cohort study Open
Background: Cardiopulmonary resuscitation (CPR) is an emergency procedure performed to bring back the heart function following cardiac arrest. Despite the establishment of emergency department and training on Pediatric Advanced Life Suppor…
View article: Hydroxyurea reduces infections in children with sickle cell anemia in Uganda
Hydroxyurea reduces infections in children with sickle cell anemia in Uganda Open
After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea …
View article: sTREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury
sTREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury Open
Background Malaria is an important cause of mortality in African children. Identification of biomarkers to identify children at risk of mortality has the potential to improve outcomes. Methods We evaluated 11 biomarkers of host response in…
View article: DISP-17. BUILDING A MODEL PEDIATRIC NEURO-ONCOLOGY PROGRAM IN SUB-SAHARAN AFRICA AND ITS IMPACT
DISP-17. BUILDING A MODEL PEDIATRIC NEURO-ONCOLOGY PROGRAM IN SUB-SAHARAN AFRICA AND ITS IMPACT Open
BACKGROUND Central nervous system tumors are the most common solid tumors in children and the second commonest childhood cancer globally. We describe the establishment of the first dedicated comprehensive pediatric neuro-oncology treatment…
View article: OTHER-05 THE CHALLENGES IN MANAGING CHILDREN WITH PRIMARY CENTRAL NERVOUS SYSTEM TUMORS IN UGANDA
OTHER-05 THE CHALLENGES IN MANAGING CHILDREN WITH PRIMARY CENTRAL NERVOUS SYSTEM TUMORS IN UGANDA Open
BACKGROUND Pediatric central nervous system tumors (CNS) are the second commonest childhood malignancy and the commonest solid tumor in children. Brain tumors are the commonest cause of death among all childhood cancers. OBJECTIVES To desc…
View article: Renin as a Biomarker of Acute Kidney Injury and Mortality in Children With Severe Malaria or Sickle Cell Disease
Renin as a Biomarker of Acute Kidney Injury and Mortality in Children With Severe Malaria or Sickle Cell Disease Open
View article: Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria
Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria Open
View article: Viral, Bacterial, Metabolic, and Autoimmune Causes of Severe Acute Encephalopathy in Sub-Saharan Africa: A Multicenter Cohort Study
Viral, Bacterial, Metabolic, and Autoimmune Causes of Severe Acute Encephalopathy in Sub-Saharan Africa: A Multicenter Cohort Study Open