Ruth Peters
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View article: Associations of blood pressure parameters with cognitive decline and dementia: a systematic review of reviews
Associations of blood pressure parameters with cognitive decline and dementia: a systematic review of reviews Open
Background Evidence syntheses on the associations between blood pressure (BP) parameters and cognitive decline and/or dementia have taken different methodological approaches and targeted different BP parameters and outcomes. The aim of thi…
View article: A critical review and classification of dementia risk assessment tools to inform dementia risk reduction
A critical review and classification of dementia risk assessment tools to inform dementia risk reduction Open
Addressing modifiable dementia risk factors requires reliable risk assessment methods. We aimed to synthesise knowledge on risk scores for all cause dementia, Alzheimer's disease (AD) and vascular dementia, classify them according to targe…
View article: Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study
Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study Open
Introduction Studies on the association between lipid levels and lipid-lowering treatment and the risk of dementia and/or cognitive decline (CD) have shown conflicting results and are few in individuals with type 2 diabetes (T2D). The aim …
View article: Statistical analysis plan for the STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER) study: a randomised, open label, controlled trial in subjects with persistent neurological symptoms after COVID-19 infection
Statistical analysis plan for the STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER) study: a randomised, open label, controlled trial in subjects with persistent neurological symptoms after COVID-19 infection Open
We outline the statistical análysis plan (SAP) for the STatin TReatment for COVID-19 to Optimise NeuroloGical (STRONGER) study. STRONGER is an international, investigator-initiated and conducted, multicentre, prospective, randomised, open …
View article: Combined mind–body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial
Combined mind–body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial Open
Health and Medical Research Fund.
View article: STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection
STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection Open
Introduction Increasing awareness of the high frequency, wide spectrum and disabling nature of symptoms that can persist following COVID-19 infection has prompted the investigation of management strategies. Our study aims to determine the …
View article: Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE
Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE Open
HLFs are associated with lower risks of major macrovascular and microvascular events and lower rates of death in high-risk adults with T2D.
View article: Maintaining level of modifiable dementia risk scores is associated with better cognitive outcomes than increasing risk scores: A population-based prospective cohort study
Maintaining level of modifiable dementia risk scores is associated with better cognitive outcomes than increasing risk scores: A population-based prospective cohort study Open
Efforts to maintain a brain healthy lifestyle could reduce the risk for MCI or dementia, and slow cognitive decline.
View article: Decentralised clinical trials for medications to reduce the risk of dementia: consensus report and guidance
Decentralised clinical trials for medications to reduce the risk of dementia: consensus report and guidance Open
Background Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralised clinical trials in dementia. There are many potential benefits associated with decentralise…
View article: A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies
A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies Open
The DemNCD is the first tool to predict both dementia and multiple cardio-metabolic diseases using comprehensive risk factors and provided similar predictive accuracy to existing risk tools. It has similar predictive accuracy as tools desi…
View article: Ageing and Decision-making: A systematic review and meta-analysis
Ageing and Decision-making: A systematic review and meta-analysis Open
Objectives This systematic review aimed to synthesise the evidence on potential differences in financial, social, health and safety-related decision-making between younger and older adults. Methods Trial, experimental, and prospective stud…
View article: Contrast Sensitivity, Visual Field, Color Vision, Motion Perception, and Cognitive Impairment: A Systematic Review
Contrast Sensitivity, Visual Field, Color Vision, Motion Perception, and Cognitive Impairment: A Systematic Review Open
View article: Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance
Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance Open
INTRODUCTION Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentrali…
View article: Levels of frailty and frailty progression in older urban- and regional-living First Nations Australians
Levels of frailty and frailty progression in older urban- and regional-living First Nations Australians Open
View article: A 10-week intergenerational program bringing together community-living older adults and preschool children (INTERACTION): a pilot feasibility non-randomised clinical trial
A 10-week intergenerational program bringing together community-living older adults and preschool children (INTERACTION): a pilot feasibility non-randomised clinical trial Open
Background Social isolation and low levels of physical activity are strong drivers for frailty, which is linked to poor health outcomes and transition to long-term care. Frailty is multifactorial, and thus an integrated approach is needed …
View article: ASSOCIATION BETWEEN BLOOD PRESSURE VARIABILITY WITH DEMENTIA AND COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS
ASSOCIATION BETWEEN BLOOD PRESSURE VARIABILITY WITH DEMENTIA AND COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
View article: Umbrella review and Delphi study on modifiable factors for dementia risk reduction
Umbrella review and Delphi study on modifiable factors for dementia risk reduction Open
A 2013 systematic review and Delphi consensus study identified 12 modifiable risk and protective factors for dementia, which were subsequently merged into the “LIfestyle for BRAin health” (LIBRA) score. We systematically evaluated whether …
View article: What do we still need to know about antihypertensives and dementia prevention?
What do we still need to know about antihypertensives and dementia prevention? Open
There is a substantial evidence base linking higher blood pressures to an increased risk of cognitive decline and dementia and an increasingly strong evidence base showing reduced dementia risk with blood pressure lowering. Several clinica…
View article: NOT ALL CREATED EQUAL: THE IMPACTS OF POSITIVE, NEGATIVE, AND PARTNER RELATIONSHIPS ON COGNITION IN LATELIFE
NOT ALL CREATED EQUAL: THE IMPACTS OF POSITIVE, NEGATIVE, AND PARTNER RELATIONSHIPS ON COGNITION IN LATELIFE Open
Background Social engagement has been linked to higher cognitive function in later life and it is a well evidenced protective factor against dementia and cognitive decline. However, far less is understood about how the type, quality and qu…
View article: Perspectives of older adults and general practitioners on ageing and cognitive decline in primary care within the context of a decentralised antihypertensive dementia prevention trial
Perspectives of older adults and general practitioners on ageing and cognitive decline in primary care within the context of a decentralised antihypertensive dementia prevention trial Open
Background Blood pressure (BP) lowering is the most promising strategy for dementia risk reduction. 1 However, few clinical trials have been designed to evaluate the impact of BP lowering on dementia as a primary endpoint, and concerns per…
View article: Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease
Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease Open
Importance There are ongoing concerns about the benefits of intensive vs standard blood pressure (BP) treatment among adults with orthostatic hypotension or standing hypotension. Objective To determine the effect of a lower BP treatment go…
View article: Use of Antihypertensives, Blood Pressure, and Estimated Risk of Dementia in Late Life
Use of Antihypertensives, Blood Pressure, and Estimated Risk of Dementia in Late Life Open
Importance The utility of antihypertensives and ideal blood pressure (BP) for dementia prevention in late life remains unclear and highly contested. Objectives To assess the associations of hypertension history, antihypertensive use, and b…
View article: Work engagement, psychological empowerment and relational coordination in long‐term care: A mixed‐method examination of nurses' perceptions and experiences
Work engagement, psychological empowerment and relational coordination in long‐term care: A mixed‐method examination of nurses' perceptions and experiences Open
Nurse engagement, empowerment and strong relationships among staff, residents and families, are essential to attract and retain a suitably qualified and skilled nursing workforce for safe, quality care. There is, however, limited research …
View article: CogDrisk, ANU-ADRI, CAIDE, and LIBRA Risk Scores for Estimating Dementia Risk
CogDrisk, ANU-ADRI, CAIDE, and LIBRA Risk Scores for Estimating Dementia Risk Open
Importance While the Australian National University–Alzheimer Disease Risk Index (ANU-ADRI), Cardiovascular Risk Factors, Aging, and Dementia (CAIDE), and Lifestyle for Brain Health (LIBRA) dementia risk tools have been widely used, a larg…
View article: Preferences and Perspectives of Australian General Practitioners Towards a New “Four-in-One” Risk Assessment Tool for Preventative Health: The LEAD! GP Project
Preferences and Perspectives of Australian General Practitioners Towards a New “Four-in-One” Risk Assessment Tool for Preventative Health: The LEAD! GP Project Open
Background: Dementia risk reduction is a public health priority and general practitioners (GPs) play a pivotal role in preventative healthcare. Therefore, risk assessment tools should be designed with GPs’ preferences and perspectives in m…
View article: Protocol development to study launch: The Australian‐multidomain approach to reduce dementia risk by protecting brain health With lifestyle intervention (AU‐ARROW) study
Protocol development to study launch: The Australian‐multidomain approach to reduce dementia risk by protecting brain health With lifestyle intervention (AU‐ARROW) study Open
Background The Finnish Geriatric Intervention Study (FINGER) reported that a multidomain lifestyle intervention could provide an effective and accessible means of protecting against age‐related cognitive decline and dementia. This led to t…
View article: Higher systolic blood pressure in early‐mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non‐carriers. Results from the DIAN study
Higher systolic blood pressure in early‐mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non‐carriers. Results from the DIAN study Open
BACKGROUND The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal‐dominant Alzheimer's disease mutation carriers (MCs…
View article: Testing times for dementia: a community survey identifying contemporary barriers to risk reduction and screening
Testing times for dementia: a community survey identifying contemporary barriers to risk reduction and screening Open
Background Advances in pharmacological and non-pharmacological dementia interventions may mean future dementia prevention incorporates a combination of targeted screening and lifestyle modifications. Elucidating potential barriers which ma…
View article: Validation of the CogDrisk Instrument as Predictive of Dementia in Four General Community-Dwelling Populations
Validation of the CogDrisk Instrument as Predictive of Dementia in Four General Community-Dwelling Populations Open
View article: Frequency of coexistent eye diseases and cognitive impairment or dementia: a systematic review and meta-analysis
Frequency of coexistent eye diseases and cognitive impairment or dementia: a systematic review and meta-analysis Open