Ruth R. Hagen
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View article: HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes
HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes Open
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in n…
View article: Historic 1994 influenza vaccine cohorts reveal breadth of antibody and B cell responses towards three decades of future influenza A and B viruses
Historic 1994 influenza vaccine cohorts reveal breadth of antibody and B cell responses towards three decades of future influenza A and B viruses Open
Influenza vaccination is the best way to combat annual influenza epidemics, yet the breadth of vaccine-induced humoral immunity towards decades of future differentially-evolving influenza A and B viruses is unclear. Using historic 1994 inf…
View article: Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua
Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua Open
Human pregnancy presents a unique physiological state that allows for growth of an antigenically dissimilar foetus and requires specific adaptations of the immune system. The immune system plays an important role in establishing and mainta…
View article: Methotrexate treatment hampers induction of vaccine-specific CD4 T cell responses in patients with IMID
Methotrexate treatment hampers induction of vaccine-specific CD4 T cell responses in patients with IMID Open
Objectives Methotrexate (MTX) is one of the most commonly used medications to treat rheumatoid arthritis (RA). However, the effect of MTX treatment on cellular immune responses remains incompletely understood. This raises concerns about th…
View article: SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years
SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Open
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-Co…
View article: T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination
T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination Open
Background Messenger RNA (mRNA) vaccines provide robust protection against SARS-CoV-2 in healthy individuals. However, immunity after vaccination of patients with multiple sclerosis (MS) treated with ocrelizumab (OCR), a B cell-depleting a…
View article: Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples
Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples Open
View article: mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses
mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses Open
SARS-CoV-2-specific CD8+ T cells recognize conserved viral peptides and in the absence of cross-reactive antibodies form an important line of protection against emerging viral variants as they ameliorate disease severity. SARS-C…
View article: Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273
Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273 Open
Background: Patients affected by different types of autoimmune diseases, including common conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated with immunosuppressants to suppress disease activity. It …
View article: Author response: Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273
Author response: Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273 Open
Article Figures and data Abstract Editor's evaluation Introduction Materials and methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: Patients a…
View article: Polyfunctional pathogen-specific CD4 <sup>+</sup> T cells reside in the lungs and tumors of NSCLC patients
Polyfunctional pathogen-specific CD4 <sup>+</sup> T cells reside in the lungs and tumors of NSCLC patients Open
Local T cell responses are required for optimal protection of the lungs against airborne pathogens. This localized protection is mediated by various immune cells, including resident memory T cells (T RM ). While human lung CD8 + T RM line …
View article: Parallel detection of <scp>SARS‐CoV</scp>‐2 epitopes reveals dynamic immunodominance profiles of <scp>CD8</scp><sup>+</sup> T memory cells in convalescent <scp>COVID</scp>‐19 donors
Parallel detection of <span>SARS‐CoV</span>‐2 epitopes reveals dynamic immunodominance profiles of <span>CD8</span><sup>+</sup> T memory cells in convalescent <span>COVID</span>‐19 donors Open
Objectives High‐magnitude CD8 + T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8 + T cell‐mediated protection are not well understood. The antigenic breadth and the immunod…
View article: Metastastatic basal cell carcinoma – A case report
Metastastatic basal cell carcinoma – A case report Open
The basal cell carcinoma (BCC) is the most common malignant skin tumor. It is characterized by a local-infiltrative and destructive growth, metastatic spread is extremely rare. Its rarest form is the sklerodermiform subtype. It shows spurs…
View article: Clinical and molecular analysis of sinunasal melanomas
Clinical and molecular analysis of sinunasal melanomas Open
Sinunasal melanoma (SNM) is a rare and aggressive disease with a 5-year survival rate of 25 %. The therapy standard is surgery with adjuvant radiotherapy. However, immune checkpoint inhibitors (ICIs) are increasingly used in the treatment …