Ruth S. Nelson
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View article: Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling
Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling Open
Deep molecular phenotyping of cells at transcriptomic and proteomic levels is an essential first step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances onl…
View article: In vivo TurboID labeling for paired proteomic and transcriptomic profiling of neurons and astrocytes
In vivo TurboID labeling for paired proteomic and transcriptomic profiling of neurons and astrocytes Open
Background Our group has developed the innovative proximity labeling cell‐type specific in vivo biotinylation of proteins (CIBOP) approach to quantify cell‐specific in vivo proteomic and transcriptomic signatures that may lead to identify …
View article: Representation Learning of Geometric Trees
Representation Learning of Geometric Trees Open
Geometric trees are characterized by their tree-structured layout and\nspatially constrained nodes and edges, which significantly impacts their\ntopological attributes. This inherent hierarchical structure plays a crucial\nrole in domains …
View article: Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC
Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC Open
View article: Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology
Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology Open
Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally…
View article: Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model
Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model Open
Background Perineuronal nets (PNNs) are extracellular matrix structures that surround neurons and proximal dendrites and regulate synaptic transmission, plasticity, and several facets of memory. PNNs are commonly associated with parvalbumi…
View article: In vivo TurboID proximity labeling to capture astrocyte proteomic and transcriptomic signatures under homeostatic and neuroinflammatory conditions
In vivo TurboID proximity labeling to capture astrocyte proteomic and transcriptomic signatures under homeostatic and neuroinflammatory conditions Open
Background Despite decades of research into the cellular and molecular contributions of brain cell types to Alzheimer’s disease (AD) pathogenesis, there are no glial‐specific disease‐modifying therapies. To address this, our group has deve…
View article: A neuropathologic feature of brain aging: multi-lumen vascular profiles
A neuropathologic feature of brain aging: multi-lumen vascular profiles Open
View article: Exploratory mass spectrometry of cerebrospinal fluid from persons with autopsy-confirmed LATE-NC
Exploratory mass spectrometry of cerebrospinal fluid from persons with autopsy-confirmed LATE-NC Open
Background : Common neuropathologies associated with dementia include Alzheimer’s disease neuropathologic change (ADNC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). Biofluid proteomics provides…
View article: Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort
Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort Open
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms of dementia (BPSD) commonly impair quality of life and complicate clinical management. To …
View article: Urinary Incontinence in a Community-Based Autopsy Cohort Is Associated with Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Changes
Urinary Incontinence in a Community-Based Autopsy Cohort Is Associated with Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Changes Open
Background: Dementia and urinary incontinence (UI) are etiologically complex clinical syndromes. Dementia and UI often occur in the same individuals, but underlying factors connecting them are incompletely understood. Objective: Query data…
View article: Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer’s disease pathology
Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer’s disease pathology Open
SUMMARY One of the earliest pathophysiological perturbations in Alzheimer’s Disease (AD) may arise from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early protein-level (proteomic) alterations in PV-INs can …
View article: Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms
Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms Open
Neurodegenerative diseases (NDs) involve complex cellular mechanisms that are incompletely understood. Emerging findings have revealed that disruption of nuclear processes play key roles in ND pathogenesis. The nucleus is a nexus for gene …
View article: Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts Open
View article: Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain
Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain Open
View article: Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brain
Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brain Open
Isolation and proteomic profiling of brain cell types, particularly neurons, pose several technical challenges which limit our ability to resolve distinct cellular phenotypes in neurological diseases. Therefore, we generated a novel mouse …
View article: The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases Open
Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged brains often is accompanied by the misfolding of other proteins, suggesting synergistic m…