Ruth Shalgi
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View article: Engineering mice for female-biased progeny without impacting genetic integrity and litter size
Engineering mice for female-biased progeny without impacting genetic integrity and litter size Open
Generating mammalian gametes with a skewed sex ratio has thus far eluded empirical confirmation. The utilization of such genetically engineered organisms would offer the potential to curtail the necessity for culling animals of undesirable…
View article: The direct effect of SARS-CoV-2 virus vaccination on human ovarian granulosa cells explains menstrual irregularities
The direct effect of SARS-CoV-2 virus vaccination on human ovarian granulosa cells explains menstrual irregularities Open
Following administration of the SARS-CoV-2 vaccine, many women worldwide reported short-term menstrual irregularities. Although menstrual bleeding, “the fifth vital sign”, is experienced by more than 300 million people on any given day wor…
View article: Engineering mice for female-biased progeny without impacting genetic integrity and litter size
Engineering mice for female-biased progeny without impacting genetic integrity and litter size Open
Generating mammalian gametes with a skewed sex ratio has thus far eluded empirical confirmation. The utilization of such genetically engineered organisms would offer the potential to curtail the necessity for culling animals of undesirable…
View article: Supplementary Figures 1 through 3 from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia
Supplementary Figures 1 through 3 from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia Open
Figure 1: schematic representation of experimental design Figure 2: Histological manifestation of treated uteri at the short-term setting Figure 3: uterine characteristics following "rPEDF prevention" regimen
View article: Data from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia
Data from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia Open
Tamoxifen is a cornerstone component of adjuvant endocrine therapy for patients with hormone-receptor–positive breast cancer. Its significant adverse effects include uterine hyperplasia, polyps, and increased risk of endometrial cancer. Ho…
View article: Supplementary Figures 1 through 3 from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia
Supplementary Figures 1 through 3 from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia Open
Figure 1: schematic representation of experimental design Figure 2: Histological manifestation of treated uteri at the short-term setting Figure 3: uterine characteristics following "rPEDF prevention" regimen
View article: Data from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia
Data from Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia Open
Tamoxifen is a cornerstone component of adjuvant endocrine therapy for patients with hormone-receptor–positive breast cancer. Its significant adverse effects include uterine hyperplasia, polyps, and increased risk of endometrial cancer. Ho…
View article: Nutrition Alters the Stiffness of Adipose Tissue and Cell Signaling
Nutrition Alters the Stiffness of Adipose Tissue and Cell Signaling Open
Adipose tissue is a complex organ composed of various cell types and an extracellular matrix (ECM). The visceral adipose tissue (VAT) is dynamically altered in response to nutritional regimens that lead to local cues affecting the cells an…
View article: The Role of PEDF in Reproductive Aging of the Ovary
The Role of PEDF in Reproductive Aging of the Ovary Open
Reproductive aging is characterized by a decline in ovarian function and in oocytes’ quantity and quality. Pigment epithelium-derived factor (PEDF), a pivotal player in ovarian angiogenic and oxidative balance, was evaluated for its involv…
View article: Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity
Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity Open
Background: Gonadal toxicity following chemotherapy is an important issue among the population of young cancer survivors. The inhibitor of DNA topoisomerase I, irinotecan (CPT-11), is widely used for several cancer types. However, little i…
View article: Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation
Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation Open
Fertilization triggers physiological degradation of maternal-mRNAs, which are then replaced by embryonic transcripts. Ample evidence suggests that Argonaut 2 (AGO2) is a possible post-fertilization regulator of maternal-mRNAs degradation; …
View article: Pretreatment with gonadotropin-releasing hormone antagonist protects against chemotherapy-induced testicular damage in mice
Pretreatment with gonadotropin-releasing hormone antagonist protects against chemotherapy-induced testicular damage in mice Open
Background: Testicular toxicity following chemotherapy is of increasing importance with the continuous improvement of survival rates. Gonadotropin-releasing hormone (GnRH) was suggested to protect testis against such toxicity; however, its…
View article: Anti-HER2/neu Antibody Reduces Chemotherapy-Induced Ovarian Toxicity—From Bench to Bedside
Anti-HER2/neu Antibody Reduces Chemotherapy-Induced Ovarian Toxicity—From Bench to Bedside Open
Background: Trastuzumab, a humanized anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, is considered a standard treatment in addition to chemotherapy in the adjuvant setting for HER2/neu-positive breast cancer, yet its imp…
View article: Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity
Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity Open
Breast cancer is diagnosed in ~0.3% of pregnant women. Studies that have addressed gestational and neonatal outcomes of chemotherapy during pregnancy have demonstrated increased gestational complications including preeclampsia and intraute…
View article: Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features
Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features Open
Polycystic ovary syndrome (PCOS), one of the most common female endocrine disorder, is a prevalent cause of infertility. Hyperandrogenism is a key feature in PCOS and is correlated with increased expression of VEGF and cytokines in the ova…
View article: miR-125a Induces HER2 Expression and Sensitivity to Trastuzumab in Triple-Negative Breast Cancer Lines
miR-125a Induces HER2 Expression and Sensitivity to Trastuzumab in Triple-Negative Breast Cancer Lines Open
The EGFR/HER2 signaling network is an effective therapeutic target for HER2-positive cancers, which are known for their aggressive biological course. Evidence indicates that the EGFR/HER2 network plays a role in the aggressive basal-like s…
View article: Pre-ovulatory intercellular regulation of miR-125a-3p within mouse ovarian follicles
Pre-ovulatory intercellular regulation of miR-125a-3p within mouse ovarian follicles Open
miR-125a-3p, a post-transcription regulator of Fyn kinase, is expressed in mouse pre-ovulatory follicles; its expression within the follicle decreases toward ovulation. Our aim was to follow the synthesis of miR-125a-3p and regulation of i…
View article: Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models
Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models Open
PCOS is the most common endocrinopathy in women; associated with obesity and insulin resistance (IR). IR leads to accumulation of advanced-glycation-end-products (AGEs) and their receptor, RAGE. PCOS patients have increased levels of vascu…
View article: Treosulfan induces distinctive gonadal toxicity compared with busulfan
Treosulfan induces distinctive gonadal toxicity compared with busulfan Open
Treosulfan (L-treitol-1,4-bis-methanesulfonate) has been increasingly incorporated as a main conditioning protocol for hematopoietic stem cell transplantation in pediatric malignant and non-malignant diseases. Treosulfan presents lower tox…
View article: Premature ovarian aging in <i>BRCA</i> carriers: a prototype of systemic precocious aging?
Premature ovarian aging in <i>BRCA</i> carriers: a prototype of systemic precocious aging? Open
Our results suggest a link between BRCA mutation, accelerated ovarian aging and systemic aging-related pathophysiology.
View article: The Dual Role of PEDF in the Pathogenesis of OHSS: Negating Both Angiogenic and Inflammatory Pathways
The Dual Role of PEDF in the Pathogenesis of OHSS: Negating Both Angiogenic and Inflammatory Pathways Open
Our findings provide a framework that correlates down-regulation of OHSS symptoms caused by PEDF with both angiogenic and inflammatory pathways.
View article: Pigment epithelium-derived factor regulation by human chorionic gonadotropin in granulosa cells
Pigment epithelium-derived factor regulation by human chorionic gonadotropin in granulosa cells Open
Human chorionic gonadotropin (hCG) is a known trigger of ovarian hyperstimulation syndrome (OHSS), a potentially life-threatening complication of assisted reproduction. Administration of hCG results in the release of vascular endothelial g…
View article: Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia
Pigment Epithelium–Derived Factor Alleviates Tamoxifen-Induced Endometrial Hyperplasia Open
Tamoxifen is a cornerstone component of adjuvant endocrine therapy for patients with hormone-receptor–positive breast cancer. Its significant adverse effects include uterine hyperplasia, polyps, and increased risk of endometrial cancer. Ho…