Ruud Duijkers
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View article: The Value of Soluble Urokinase Plasminogen Activator Receptor (suPAR) as Predictive Tool in Hospitalised Patients With Community‐Acquired Pneumonia (CAP)
The Value of Soluble Urokinase Plasminogen Activator Receptor (suPAR) as Predictive Tool in Hospitalised Patients With Community‐Acquired Pneumonia (CAP) Open
Background Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker elevated in severely ill patients, but its prognostic value in community‐acquired pneumonia (CAP) remains unclear. This study aimed to evaluate suPAR's prog…
View article: Biomarker guided antibiotic stewardship in community acquired pneumonia: A randomized controlled trial
Biomarker guided antibiotic stewardship in community acquired pneumonia: A randomized controlled trial Open
Background In community-acquired pneumonia (CAP), the role of biomarkers to shorten duration of antibiotic treatment has not been firmly established. We assessed the effectiveness of active feedback of treatment algorithms based on procalc…
View article: Implementation of biomarkers in the management of Community-Acquired Pneumonia
Implementation of biomarkers in the management of Community-Acquired Pneumonia Open
Chapter 1: We developed a real-time PCR test to detect pneumococci. The test was accurate both in vitro and oropharyngeal patient samples. It showed good reliability and has a detection threshold of 1-10 DNA copies per reaction, with a ver…
View article: Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial
Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial Open
BCG vaccination does not protect older adults with comorbidities against COVID-19, COVID-19 hospitalization, or clinically relevant RTIs.
View article: Validating a clinical prediction score for Legionella-related community acquired pneumonia
Validating a clinical prediction score for Legionella-related community acquired pneumonia Open
View article: Relationship between biomarkers and findings on low-dose computed tomography in hospitalised patients with acute exacerbation of COPD
Relationship between biomarkers and findings on low-dose computed tomography in hospitalised patients with acute exacerbation of COPD Open
Background Acute exacerbations of COPD (AECOPD) and community acquired pneumonia (CAP) often coexist. Although chest radiographs may differentiate between these diagnoses, chest radiography is known to underestimate the incidence of CAP in…
View article: COPD-Lower Respiratory Tract Infection Visual Analogue Score (c-LRTI-VAS) validation in stable and exacerbated patients with COPD
COPD-Lower Respiratory Tract Infection Visual Analogue Score (c-LRTI-VAS) validation in stable and exacerbated patients with COPD Open
Background We developed the chronic obstructive pulmonary disease (COPD)-Lower Respiratory Tract Infection-Visual Analogue Score (c-LRTI-VAS) in order to easily quantify symptoms during exacerbations in patients with COPD. This study aimed…
View article: CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions
CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions Open
The role of antibiotics in acute exacerbations of chronic obstructive pulmonary disease (COPD) is controversial and a biomarker identifying patients who benefit from antibiotics is mandatory. We performed a randomised, controlled trial in …
View article: Feasibility of a quantitative polymerase chain reaction assay for diagnosing pneumococcal pneumonia using oropharyngeal swabs
Feasibility of a quantitative polymerase chain reaction assay for diagnosing pneumococcal pneumonia using oropharyngeal swabs Open
View article: Blood eosinophilia as a marker of early and late treatment failure in severe acute exacerbations of COPD
Blood eosinophilia as a marker of early and late treatment failure in severe acute exacerbations of COPD Open