Ruixiang Chen
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View article: Efficacy and safety of anlotinib in the treatment of brain metastases from non-small cell lung cancer: a systematic review and meta-analysis
Efficacy and safety of anlotinib in the treatment of brain metastases from non-small cell lung cancer: a systematic review and meta-analysis Open
Background The presence of brain metastases is a significant factor contributing to the failure of lung cancer therapies. This study aims to systematically assess the efficacy and safety of anlotinib in the treatment of brain metastases re…
View article: Molecular Mechanism by Which the BrFIT2–BrbHLH–BrIRT1 Module Synergistically Regulates Iron Absorption in <i>Brassica rapa</i> ssp. <i>Pekinensis</i>
Molecular Mechanism by Which the BrFIT2–BrbHLH–BrIRT1 Module Synergistically Regulates Iron Absorption in <i>Brassica rapa</i> ssp. <i>Pekinensis</i> Open
Iron is essential for plant photosynthesis and human health, yet Brassica rapa ssp. pekinensis exhibits significantly lower iron content compared to other leafy vegetables, and its iron uptake mechanisms are not well understood. This study…
View article: Immersive AR-assisted assemblies for self-building strategies using prefabricated timber components
Immersive AR-assisted assemblies for self-building strategies using prefabricated timber components Open
Augmented reality (AR) technology has the potential to play a pivotal role in on-site construction activities by providing workers with hands-free access to virtual content and information through interactive experiences overlayed on the r…
View article: A real-world pharmacovigilance study of lorazepam based on the FDA adverse event reporting system database
A real-world pharmacovigilance study of lorazepam based on the FDA adverse event reporting system database Open
Lorazepam is extensively used to treat anxiety disorders and anxiety associated with depression. This study evaluates the safety of lorazepam based on real-world data from the U.S. Food and Drug Administration Adverse Event Reporting Syste…
View article: Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity
Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity Open
Significant data suggest that cerebral accumulation of the amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD), however, Aβ can exist in multiple different forms and it is not clear which of these contribute to the …
View article: NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3
NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3 Open
NRXN3 plays a crucial role in maintaining chemotherapy-induced pyroptosis in ICC. Targeting the NRXN3/RSK1/FBXO1/caspase-3 axis emerges as a promising strategy for ICC treatment, with the potential to improve chemosensitivity and survival.
View article: Fast inverse lithography based on a model-driven block stacking convolutional neural network
Fast inverse lithography based on a model-driven block stacking convolutional neural network Open
In the realm of lithography, optical proximity correction (OPC) is a crucial resolution enhancement technique that optimizes the transmission function of photomasks on a pixel-based level to effectively counter optical proximity effects (O…
View article: Theoretical demonstration of partially coherent Fourier light field microscopy for single-shot three-dimensional imaging
Theoretical demonstration of partially coherent Fourier light field microscopy for single-shot three-dimensional imaging Open
Fourier light field microscopy (FLFM) has emerged as a valuable tool for single-shot three-dimensional imaging largely due to its ability to reduce reconstruction artifacts and facilitate efficient parallel processing. However, existing re…
View article: Identification of a pyroptosis-related gene prognostic signature in patients with hepatocellular carcinoma
Identification of a pyroptosis-related gene prognostic signature in patients with hepatocellular carcinoma Open
We developed and verified a prognostic risk model based on PRGs for patients with HCC, which may provide a robust tool for predicting outcomes in this setting.
View article: Fast inverse lithography based on a model-driven block stacking convolutional neural network
Fast inverse lithography based on a model-driven block stacking convolutional neural network Open
In the realm of lithography, Optical Proximity Correction (OPC) is a crucial resolution enhancement technique that optimizes the transmission function of photomasks on a pixel-based to effectively counter Optical Proximity Effects (OPE). H…
View article: Controllable orbital-to-spin angular momentum conversion in tight focusing of spatiotemporal vortex wavepacket
Controllable orbital-to-spin angular momentum conversion in tight focusing of spatiotemporal vortex wavepacket Open
In this paper, we investigate the tight focusing of the radially polarized spatiotemporal vortex (STV) wavepackets. We find that, by changing the initial phase of the incident polarization state, the intensity envelope of the tightly focus…
View article: Improvement of X-ray Photoelectric Conversion Performance of MAPbI3 Perovskite Crystals by Ionic Liquid Treatment
Improvement of X-ray Photoelectric Conversion Performance of MAPbI3 Perovskite Crystals by Ionic Liquid Treatment Open
Although perovskite has great potential in optoelectronic devices, the simultaneous satisfaction of material stability and high performance is still an issue that needs to be solved. Most perovskite optoelectronic devices use quantum dot s…
View article: CircPCNXL2 promotes tumor growth and metastasis by interacting with STRAP to regulate ERK signaling in intrahepatic cholangiocarcinoma
CircPCNXL2 promotes tumor growth and metastasis by interacting with STRAP to regulate ERK signaling in intrahepatic cholangiocarcinoma Open
Background circular RNAs (circRNAs) have been reported to exert important effects in the progression of numerous cancers. However, the functions of circRNAs in intrahepatic cholangiocarcinoma (ICC) are still unclear. Methods circPCNXL2 (ha…
View article: Predicting the unpredictable: a robust nomogram for predicting recurrence in patients with ampullary carcinoma
Predicting the unpredictable: a robust nomogram for predicting recurrence in patients with ampullary carcinoma Open
Objective To screen the risk factors affecting the recurrence risk of patients with ampullary carcinoma (AC)after radical resection, and then to construct a model for risk prediction based on Lasso-Cox regression and visualize it. Methods …
View article: Dual-color emissive OLED with orthogonal polarization modes
Dual-color emissive OLED with orthogonal polarization modes Open
Linearly polarized organic light-emitting diodes have become appealing functional expansions of polarization optics and optoelectronic applications. However, the current linearly polarized diodes exhibit low polarization performance, cost-…
View article: Effectiveness of PD1/PD-L1 combined with anti-angiogenic drugs in patients with advanced nonsmall cell lung cancer: A systematic review and meta-analysis
Effectiveness of PD1/PD-L1 combined with anti-angiogenic drugs in patients with advanced nonsmall cell lung cancer: A systematic review and meta-analysis Open
Background: Protein-1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) therapy have become an important treatment approach for patients with advanced nonsmall cell lung cancer (NSCLC), but primary or secondary resistance remains a chall…
View article: USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma
USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma Open
Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential in cholangiocarcinoma (CCA) has not been explored. Herein…
View article: Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia: A systematic review and meta-analysis
Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia: A systematic review and meta-analysis Open
Background: Caffeic acid tablets (CFA) are a proprietary Chinese medicine in treating thrombocytopenia. The efficacy and safety of CFA compared with other platelet-raising drugs for the treatment of thrombocytopenia have been widely report…
View article: CircCRIM1 promotes intrahepatic cholangiocarcinoma progression by inhibiting ferroptosis via miR-124-5p/TXNRD1 axis
CircCRIM1 promotes intrahepatic cholangiocarcinoma progression by inhibiting ferroptosis via miR-124-5p/TXNRD1 axis Open
Background and aim: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant subtype of cholangiocarcinoma (CCA) with a poor prognosis and limited therapeutic effectiveness, prompting further study to develop novel therapies for ICC. Tu…
View article: Dual-color emissive OLED with orthogonal polarization modes
Dual-color emissive OLED with orthogonal polarization modes Open
Linearly polarized organic light-emitting diodes (LP-OLEDs) have become an appealing functional expansion in polarization optics and optoelectronic applications. However, this current LP-OLED generally presents comprehensively lower polari…
View article: Inverse Energy Flux in Tight Focusing of Vector Vortex Beam
Inverse Energy Flux in Tight Focusing of Vector Vortex Beam Open
In this paper, we focus on the study of the negative energy flow in the tight focusing of a radially polarized vortex beam. We know that, because of the coupling of the polarization state and the vortex charge, the on-axis energy flow in t…
View article: Surface Vertical Multi-Emission Laser with Distributed Bragg Reflector Feedback from CsPbI3 Quantum Dots
Surface Vertical Multi-Emission Laser with Distributed Bragg Reflector Feedback from CsPbI3 Quantum Dots Open
Quantum dots (QDs) laser has become an important way to solve micro-application problems in many fields. However, single wavelength distributed Bragg reflector (DBR) has many limitations in practical applications, such as signal transmissi…
View article: Efficacy of metformin adjunctive therapy as the treatment for non-diabetic patients with advanced non-small cell lung cancer: A Systematic review and Meta-analysis
Efficacy of metformin adjunctive therapy as the treatment for non-diabetic patients with advanced non-small cell lung cancer: A Systematic review and Meta-analysis Open
Background: Currently, the anticancer effects of metformin on different types of lung cancer have been frequently studied. However, the relationship between metformin and prognosis in nondiabetic patients with lung cancer remains controver…
View article: Hadron spectra and pion form factor in dynamical holographic QCD model with anomalous 5D mass of scalar field*
Hadron spectra and pion form factor in dynamical holographic QCD model with anomalous 5D mass of scalar field* Open
The simplest version of the dynamical holographic QCD model is described by adding the KKSS model action on a dilaton-graviton coupled background, in which the AdS metric is deformed by the gluon condensation and further deformed by the c…
View article: Genome-wide identification of NHX (Na+/H+ antiporter) gene family in Cucurbita L. and functional analysis of CmoNHX1 under salt stress
Genome-wide identification of NHX (Na+/H+ antiporter) gene family in Cucurbita L. and functional analysis of CmoNHX1 under salt stress Open
Soil salinization, which is the accumulation of salt in soil, can have a negative impact on crop growth and development by creating an osmotic stress that can reduce water uptake and cause ion toxicity. The NHX gene family plays an importa…
View article: Shaping focal field by grafted polarization
Shaping focal field by grafted polarization Open
In this paper, we propose a novel (to our knowledge) vector beam by combining the radially polarized beams with the different polarization orders, which is called the grafted polarization vector beam (GPVB). Compared with the tight focusin…
View article: NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1 Open
Cholangiocarcinoma (CCA) is the second most common primary hepatic malignancy and associated with poor prognosis. Lack of therapeutic methods for CCA and insensitivity of targeted therapy and immunotherapy make its treatment challenging. N…