Ri‐Yao Yang
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View article: Transcriptome Analysis of Potato (Solanum tuberosum L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance
Transcriptome Analysis of Potato (Solanum tuberosum L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance Open
Early blight, caused by the pathogen Alternaria solani, is a major fungal disease impacting potato production globally, with reported yield losses of up to 40% in susceptible varieties. As one of the most common diseases affecting potatoes…
View article: Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion
Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion Open
Background Despite the remarkable clinical outcomes of epidermal growth factor receptor (EGFR)-targeted therapies in patients with lung cancer, therapeutic resistance eventually develops. This study elucidates the role of galectin-9 (Gal-9…
View article: Galectin-12 in the Regulation of Sebocyte Proliferation, Lipid Metabolism, and Immune Responses
Galectin-12 in the Regulation of Sebocyte Proliferation, Lipid Metabolism, and Immune Responses Open
Galectin-12, a member of the galectin family of glycan-binding proteins, exhibits restricted tissue distribution, primarily in adipocytes and sebocytes. In sebocytes, it modulates the cell cycle, influences lipid metabolism through interac…
View article: Genetic and Phenotypic Architecture of Brain Glymphatic System
Genetic and Phenotypic Architecture of Brain Glymphatic System Open
Background The glymphatic system plays a crucial role in clearing metabolic waste from the brain, facilitating waste exchange between cerebrospinal fluid and interstitial fluid, and supporting brain homeostasis. However, quantifying glymph…
View article: All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer
All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer Open
As a double-stranded RNA–editing enzyme and an interferon-stimulated gene, double-stranded RNA-specific adenosine deaminase (ADAR1) suppresses interferon signaling and contributes to immunotherapy resistance. Suppression of ADAR1 overcomes…
View article: Supplementary Figure from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
Supplementary Figure from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function Open
Supplementary Figure from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
View article: Data from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
Data from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function Open
Targeting immune checkpoints such as programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has transformed cancer treatment, with durable clinical responses across a wide range of tumor types. However, a high percentage…
View article: Data from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
Data from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function Open
Targeting immune checkpoints such as programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has transformed cancer treatment, with durable clinical responses across a wide range of tumor types. However, a high percentage…
View article: Supplementary Figure from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
Supplementary Figure from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function Open
Supplementary Figure from Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
View article: Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity Open
Although current cancer immunotherapies that target PD-1/PD-L1 immune checkpoint to reinvigorate exhausted T cells have achieved impressive clinical outcomes, only a small proportion of patients respond. New therapeutic targets are therefo…
View article: Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity
Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity Open
Anthracyclines are a class of conventionally and routinely used first-line chemotherapy drugs for cancer treatment. In addition to the direct cytotoxic effects, increasing evidence indicates that the efficacy of the drugs also depends on i…
View article: Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death
Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death Open
Antibodies that target immune checkpoint proteins such as programmed cell death protein 1, programmed death ligand 1, and cytotoxic T-lymphocyte-associated antigen 4 in human cancers have achieved impressive clinical success; however, a si…
View article: Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2
Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2 Open
Enhanced sebocyte proliferation is associated with the pathogenesis of human skin diseases related to sebaceous gland hyperfunction and androgens, which are known to induce sebocyte proliferation, are key mediators of this process. Galecti…
View article: Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity Open
Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a major breakthrough in cancer treatment. PD-1 is an inhibitory receptor expressed on the surface of…
View article: Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Open
[This corrects the article on p. 2621 in vol. 10, PMID: 32905506.].
View article: Galectin-12 in Cellular Differentiation, Apoptosis and Polarization
Galectin-12 in Cellular Differentiation, Apoptosis and Polarization Open
Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recogn…
View article: Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing.
Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing. Open
The ataxia telangiectasia and Rad3-related (ATR) kinase plays a crucial role in maintaining genome stability in response to DNA damage. Once activated, ATR acts via its downstream target to arrest the cell cycle, promote DNA repair, and en…
View article: Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis
Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis Open
As a member of the galectin family of animal lectins, galectin-12 is preferentially expressed in adipocytes and leukocytes. In adipocytes, galectin-12 is associated with lipid droplets and regulates lipid metabolism and energy balance, whe…
View article: Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis
Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis Open
Galectin-12, a member of the galectin family of β-galactoside-binding animal lectins, is preferentially expressed in adipocytes and required for adipocyte differentiation in vitro. This protein was recently found to regulate lipolysis, who…