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View article: Non-amyloid specific treatment for transthyretin cardiac amyloidosis: a clinical consensus statement of the ESC Heart Failure Association
Non-amyloid specific treatment for transthyretin cardiac amyloidosis: a clinical consensus statement of the ESC Heart Failure Association Open
This clinical consensus statement, developed by the Heart Failure Association of the European Society of Cardiology, offers a detailed review of the non-specific management of transthyretin amyloid cardiomyopathy (ATTR-CM). This progressiv…
View article: A new staging system for hereditary transthyretin amyloidosis in the era of specific amyloidosis therapies
A new staging system for hereditary transthyretin amyloidosis in the era of specific amyloidosis therapies Open
Objectives Currently, there are two prognosis staging systems validated for transthyretin amyloidosis (ATTR). We sought to develop a new staging system dedicated to hereditary transthyretin amyloidosis (ATTRv) patients on specific treatmen…
View article: Cardio-oncology blitz registry offers real-world data in a gastrointestinal cancer population
Cardio-oncology blitz registry offers real-world data in a gastrointestinal cancer population Open
Abstract Cardiovascular (CV) disease in patients with cancer remains a common challenge for both patients and clinicians, and its presence increases the risk of cardiotoxicity, with an impact on prognosis. However, there is limited data on…
View article: Cardiac function and mechanics in systemic sclerosis: a systematic review and meta-analysis
Cardiac function and mechanics in systemic sclerosis: a systematic review and meta-analysis Open
Objectives The study aimed to evaluate differences in conventional, tissue Doppler imaging (TDI) and speckle-tracking echocardiographic (STE) parameters of all cardiac chambers between SSc patients and healthy controls. Methods A study sea…
View article: Diagnostic Criteria and Disease Staging for Desmoplakin Cardiomyopathy
Diagnostic Criteria and Disease Staging for Desmoplakin Cardiomyopathy Open
Background Desmoplakin (DSP) cardiomyopathy, caused by variants in the gene DSP , is a unique subtype of cardiomyopathy distinct from typical dilated or arrhythmogenic right ventricular cardiomyopathies. Specific diagnostic and disease sta…
View article: Diagnostic Accuracy of Bisphosphonate Scintigraphy in Glu54GlnATTR Cardiomyopathy
Diagnostic Accuracy of Bisphosphonate Scintigraphy in Glu54GlnATTR Cardiomyopathy Open
Background: Bisphosphonate scintigraphy (BS) is a recognized tool for diagnosing amyloid transthyretin cardiomyopathy (ATTR-CA). However, its sensitivity for rare transthyretin (TTR) variants, like Glu54Gln, remains underexplored. Methods:…
View article: Clinical Characteristics and Prognosis of Patients with End-Stage Hypertrophic Cardiomyopathy from a Tertiary Center Cohort: Systolic Dysfunction and Advanced Diastolic Dysfunction
Clinical Characteristics and Prognosis of Patients with End-Stage Hypertrophic Cardiomyopathy from a Tertiary Center Cohort: Systolic Dysfunction and Advanced Diastolic Dysfunction Open
Background: Hypertrophic cardiomyopathy (HCM) is a genetic disorder marked by myocardial hypertrophy, leading to diastolic and systolic dysfunction and heart failure. Traditionally, the burn-out stage is defined by systolic dysfunction, bu…
View article: Aorta-right atrium tunnel and mitral valve prolapse complicated with flail leaflet: a case report of a multimodality approach for an accurate diagnosis
Aorta-right atrium tunnel and mitral valve prolapse complicated with flail leaflet: a case report of a multimodality approach for an accurate diagnosis Open
Background An aorta-right atrial tunnel (ARAT) is a rare congenital cardiac anomaly that connects the aorta at any coronary sinus to the right atrium. Its cause remains unclear and may involve abnormal origins of the coronary arteries. The…
View article: Clinical management of female patients with Fabry disease based on expert consensus
Clinical management of female patients with Fabry disease based on expert consensus Open
Fabry disease is an X-linked lysosomal storage disorder that causes accumulation of glycosphingolipids in body tissues and fluids, leading to progressive organ damage and life-threatening complications. It can affect both males and females…
View article: How to assess myocardial inflammation using cardiac magnetic resonance imaging
How to assess myocardial inflammation using cardiac magnetic resonance imaging Open
View article: From Molecular to Radionuclide and Pharmacological Aspects in Transthyretin Cardiac Amyloidosis
From Molecular to Radionuclide and Pharmacological Aspects in Transthyretin Cardiac Amyloidosis Open
Amyloidosis is a rare pathology characterized by protein deposits in various organs and tissues. Cardiac amyloidosis (CA) can be caused by various protein deposits, but transthyretin amyloidosis (ATTR) and immunoglobulin light chain (AL) a…
View article: Key priorities for the implementation of the 2023 ESC Guidelines for the management of cardiomyopathies in low-resource settings
Key priorities for the implementation of the 2023 ESC Guidelines for the management of cardiomyopathies in low-resource settings Open
ESC Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource sett…
View article: Association between Left Atrial Function and Survival in Systemic Sclerosis
Association between Left Atrial Function and Survival in Systemic Sclerosis Open
Systemic sclerosis (SSc) is a multisystemic autoimmune disorder in which cardiac involvement is frequent and portends negative prognosis. Left ventricular (LV) diastolic dysfunction is one of the most common cardiac alterations in these pa…
View article: How to conduct clinical research in cardiovascular imaging: a primer for clinical cardiologists and researchers—a statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC
How to conduct clinical research in cardiovascular imaging: a primer for clinical cardiologists and researchers—a statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC Open
This statement from the European Association of Cardiovascular Imaging (EACVI) of the ESC aims to address the fundamental principles that guide clinical research in the field of cardiovascular imaging. It provides clinical researchers, car…
View article: Arrhythmogenic right ventricular cardiomyopathies (ARVC): Diagnostic challenges from imaging to genetics
Arrhythmogenic right ventricular cardiomyopathies (ARVC): Diagnostic challenges from imaging to genetics Open
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary cardiomyopathy, predominantly affecting young males, regardless of their ethnicity. Due to its variable penetrance, females usually have milder and less malignant pheno…
View article: Successful TAVI-in-TAVI for degenerated bioprosthetic aortic valve with severe stenosis-a case report
Successful TAVI-in-TAVI for degenerated bioprosthetic aortic valve with severe stenosis-a case report Open
Aortic stenosis is one of the leading causes of valvular disease requiring surgery or transcatheter intervention, with a rising prevalence due to the aging population. Current guidelines recommend transcatheter aortic valve implantation (T…
View article: Low foetal heart rate, a potentially ominous finding: case report
Low foetal heart rate, a potentially ominous finding: case report Open
Background Congenital long QT syndrome (LQTS) type 1 is characterized by abnormally prolonged ventricular repolarization caused by inherited defects in cardiac potassium channels. Patients are predisposed to ventricular arrhythmias and eve…
View article: Fabry disease phenotyping in women from the complete Romanian cohort – time for early diagnostic awareness
Fabry disease phenotyping in women from the complete Romanian cohort – time for early diagnostic awareness Open
Fabry disease (FD) is an X-linked rare disorder caused by mutations in the GLA gene. Women with FD have been less enrolled in studies and less treated compared with men. The aim of the present study is to describe the complete phenotype of…
View article: Complex management of Fabry cardiomyopathy: a case report on the use of alcohol septal ablation and chaperone therapy
Complex management of Fabry cardiomyopathy: a case report on the use of alcohol septal ablation and chaperone therapy Open
Background Cardiac involvement in Fabry disease (FD) usually manifests as a concentric left ventricular hypertrophy with rare cases developing left ventricular outflow tract obstruction (LVOTO), symptoms varying from fatigue and exercise a…
View article: Embarazo en mujeres portadoras de variantes genéticas de miocardiopatía dilatada
Embarazo en mujeres portadoras de variantes genéticas de miocardiopatía dilatada Open
View article: Cardiac amyloidosis is not a single disease: a multiparametric comparison between the light chain and transthyretin forms
Cardiac amyloidosis is not a single disease: a multiparametric comparison between the light chain and transthyretin forms Open
Aims Systemic amyloidosis represents a heterogeneous group of diseases resulting from amyloid fibre deposition. The purpose of this study is to establish a differential diagnosis algorithm targeted towards the two most frequent subtypes of…
View article: Association between left atrial function and outcome in systemic sclerosis
Association between left atrial function and outcome in systemic sclerosis Open
Purpose: Systemic sclerosis (SSc) is a multisystemic autoimmune disorder in which cardiac involvement is frequent and portends negative prognosis. Left ventricular (LV) diastolic dysfunction is one of the most common cardiac alterations in…
View article: #2199 Kidney involvement aspects in women with Fabry disease from the Romanian cohort
#2199 Kidney involvement aspects in women with Fabry disease from the Romanian cohort Open
Background and Aims Fabry disease (FD) is an X-linked rare lysosomal storage disease causing progressive nervous system, kidney and heart disorders. Progressive kidney impairment is common, and an important cause of morbidity and mortality…
View article: Pregnancy in women with dilated cardiomyopathy genetic variants
Pregnancy in women with dilated cardiomyopathy genetic variants Open
Cardiac complications during pregnancy and postpartum were common in patients with genetic DCM and were primarily related to HF. Despite apparently good tolerance of pregnancy in unaffected genetic carriers, pregnancy may act as a trigger …
View article: Genetic Characterization of Dilated Cardiomyopathy in Romanian Adult Patients
Genetic Characterization of Dilated Cardiomyopathy in Romanian Adult Patients Open
Dilated cardiomyopathy (DCM) represents a group of disorders affecting the structure and function of the heart muscle, leading to a high risk of heart failure and sudden cardiac death (SCD). DCM frequently involves an underlying genetic et…
View article: Too young for an acquired cardiomyopathy? Cobalt metallosis as a cardiac amyloidosis mimicker
Too young for an acquired cardiomyopathy? Cobalt metallosis as a cardiac amyloidosis mimicker Open
Metallosis with subsequent cardiac involvement is a possible long‐term complication of hip arthroplasty. We report the case of a young female referred to our centre for the suspicion of cardiac amyloidosis presenting with low electrocardio…
View article: Phospholamban p.Leu39* Cardiomyopathy Compared with Other Sarcomeric Cardiomyopathies: Age-Matched Patient Cohorts and Literature Review
Phospholamban p.Leu39* Cardiomyopathy Compared with Other Sarcomeric Cardiomyopathies: Age-Matched Patient Cohorts and Literature Review Open
Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic disorder, most often caused by sarcomeric gene mutations, with a small proportion due to variants in non-sarcomeric loci. Phospholamban (PLN) is a phosphoprotein associated with …
View article: Sex-specific difference in cardiac function in patients with systemic sclerosis: association with cardiovascular outcomes
Sex-specific difference in cardiac function in patients with systemic sclerosis: association with cardiovascular outcomes Open
Background Cardiovascular involvement is one of the leading causes of mortality in systemic sclerosis (SSc) and is reported to be higher in men as compared with women. However, the cause of this difference is largely unknown. The objective…
View article: Proposed diagnostic criteria for arrhythmogenic cardiomyopathy: European Task Force consensus report
Proposed diagnostic criteria for arrhythmogenic cardiomyopathy: European Task Force consensus report Open
View article: A rare cause of mixed hypertrophic and dilated phenotype cardiomyopathy – the MELAS syndrome
A rare cause of mixed hypertrophic and dilated phenotype cardiomyopathy – the MELAS syndrome Open
Introduction MELAS is a systemic hereditary condition that can present as hypertrophic or mixed hypertrophic and dilated phenotype cardiomyopathy in young individuals, although a late-onset form is also described in the literature. Genetic…