Hao Wang
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View article: Bridging Efficacy and Adherence in Glucagon-Like Peptide-1 Receptor Agonist Therapy: The Emerging Role of Oral Agents
Bridging Efficacy and Adherence in Glucagon-Like Peptide-1 Receptor Agonist Therapy: The Emerging Role of Oral Agents Open
View article: Identification of C1QA as a prognostic marker and regulator of immunosuppressive neutrophils in early-stage lung adenocarcinoma through integrated bioinformatics analyses
Identification of C1QA as a prognostic marker and regulator of immunosuppressive neutrophils in early-stage lung adenocarcinoma through integrated bioinformatics analyses Open
View article: IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR
IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR Open
View article: Efficacy and safety of thoracic radiotherapy combined with anti-angiogenic therapy and immunochemotherapy for advanced non-small cell lung cancer patients: a retrospective study
Efficacy and safety of thoracic radiotherapy combined with anti-angiogenic therapy and immunochemotherapy for advanced non-small cell lung cancer patients: a retrospective study Open
Purpose To assess the efficacy and safety of radiotherapy combined with anti-angiogenic therapy, immune checkpoint inhibitors, and chemotherapy for advanced non-small cell lung cancer (NSCLC). Methods Patients who have received at least tw…
View article: Efficacy and survival analysis of neoadjuvant chemotherapy combined with immunotherapy in locally advanced resectable Siewert type II adenocarcinoma of the esophagogastric junction
Efficacy and survival analysis of neoadjuvant chemotherapy combined with immunotherapy in locally advanced resectable Siewert type II adenocarcinoma of the esophagogastric junction Open
Background Neoadjuvant chemotherapy combined with immunotherapy (nCI) has achieved significant results in esophageal and gastric cancers, but its efficacy in Siewert type II adenocarcinoma of the esophagogastric junction (AEG) remains uncl…
View article: A novel bladder phenotype in junctional epidermolysis bullosa: a case report
A novel bladder phenotype in junctional epidermolysis bullosa: a case report Open
Background Junctional epidermolysis bullosa (JEB) is a rare inherited blistering disorder, and its urological spectrum remains poorly defined. Case Presentation A 19-month-old boy carrying compound heterozygous ITGB4 mutations (p.R252C, p.…
View article: Adherence Patterns of Oral vs Injectable GLP-1 Receptor Agonists: A National Real-World Analysis of Commercial Claims Data, 2010–2021
Adherence Patterns of Oral vs Injectable GLP-1 Receptor Agonists: A National Real-World Analysis of Commercial Claims Data, 2010–2021 Open
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly important in managing type 2 diabetes and obesity, but their effectiveness is limited by adherence challenges. While once-weekly injectable formulations may …
View article: Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer’s disease via modulating neuroinflammation
Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer’s disease via modulating neuroinflammation Open
Background Alzheimer’s disease (AD) is a neurodegenerative disease characterized by memory deficit and has emerged as a growing global health concern. Phosphodiesterase-8 (PDE8) is a cyclic adenosine monophosphate (cAMP)-specific hydrolase…
View article: Interferon Regulatory Factors as a Potential Therapeutic Target for Neuroinflammation: A Focus on Alzheimer’s Disease
Interferon Regulatory Factors as a Potential Therapeutic Target for Neuroinflammation: A Focus on Alzheimer’s Disease Open
Interferon Regulatory Factors (IRFs) are critical modulators of immune and inflammatory responses, yet their roles in Alzheimer’s disease (AD) and other neurodegenerative disorders remain incompletely understood. While IRFs are recognized …
View article: Combining machine learning and single-cell sequencing to identify key immune genes in sepsis
Combining machine learning and single-cell sequencing to identify key immune genes in sepsis Open
View article: Signalling<i>via</i>CD131 regulates pulmonary inflammation, alveolar cell death and emphysema in COPD
Signalling<i>via</i>CD131 regulates pulmonary inflammation, alveolar cell death and emphysema in COPD Open
Background COPD is a heterogenous disease where chronic inflammation is implicated in airway remodelling and emphysema. The CD131 receptor is indispensable for signalling by the β common (βc) family of cytokines encompassing granulocyte−ma…
View article: TLR7 Promotes Acute Inflammatory-Driven Lung Dysfunction in Influenza-Infected Mice but Prevents Late Airway Hyperresponsiveness
TLR7 Promotes Acute Inflammatory-Driven Lung Dysfunction in Influenza-Infected Mice but Prevents Late Airway Hyperresponsiveness Open
Severe lower respiratory tract disease following influenza A virus (IAV) infection is characterized by excessive inflammation and lung tissue damage, and this can impair lung function. The effect of toll-like receptor 7 (TLR7), which detec…
View article: Diagnostic value of impulse oscillometry in chronic obstructive pulmonary disease: a multicentre, retrospective, observational study
Diagnostic value of impulse oscillometry in chronic obstructive pulmonary disease: a multicentre, retrospective, observational study Open
Objectives Diagnosis and assessment of chronic obstructive pulmonary disease (COPD) rely extensively on spirometry, which necessitates patient cooperation. The clinical value of impulse oscillometry (IOS) as a non-volitional method in pati…
View article: Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome
Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome Open
DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohor…
View article: Technological Advances Are Associated With Better Clinical Outcomes of Percutaneous Coronary Intervention in Patients With Unprotected Left Main Disease
Technological Advances Are Associated With Better Clinical Outcomes of Percutaneous Coronary Intervention in Patients With Unprotected Left Main Disease Open
Background Few large‐scale studies have evaluated the effectiveness of percutaneous coronary intervention (PCI) technological advances in the treatment of patients with unprotected left main coronary artery disease (LM‐CAD). We aim to iden…
View article: Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages
Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages Open
Macrophages are unique immune cells attracting growing attention as a potential candidate for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme or gene‐edit macrophages hold potential across a spectrum …
View article: Improvements in advanced hepatocellular carcinoma to repeat implementation of primary protocol after cancer progression occurs following sequential systemic therapy and a clinical trial: A case report
Improvements in advanced hepatocellular carcinoma to repeat implementation of primary protocol after cancer progression occurs following sequential systemic therapy and a clinical trial: A case report Open
Introduction: Systemic therapy is recommended for patients with advanced hepatocellular carcinoma (aHCC). However, drug resistance occurs over time when patients receive systemic therapy, resulting in cancer progression. Due to the lack of…
View article: Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice
Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice Open
Background Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. However, a causal l…
View article: Adjuvant Transarterial Chemoembolization Plus Immunotherapy for Huge Hepatocellular Carcinoma: A Propensity Score Matching Cohort Study
Adjuvant Transarterial Chemoembolization Plus Immunotherapy for Huge Hepatocellular Carcinoma: A Propensity Score Matching Cohort Study Open
PA-TACE plus PD-1 inhibitors could improve survival outcomes for huge HCC patients.
View article: The Correlation between Changes in Serum Sodium and Hospital Mortality in Critically Ill Children with Acute Kidney Injury
The Correlation between Changes in Serum Sodium and Hospital Mortality in Critically Ill Children with Acute Kidney Injury Open
For critically ill patients with acute kidney injury (AKI), early warning and intervention can be achieved through monitoring serum sodium levels. However, the normal range of serum sodium levels in AKI patients in the intensive care unit …
View article: Anti-Cancer Agents Associated Diarrhea: Current Status and Prospects
Anti-Cancer Agents Associated Diarrhea: Current Status and Prospects Open
Cancer stands as one of the major threats to human life. Ensuring the safety of drugs is paramount, and the impact of adverse reactions on patients’ quality of life and prognosis should not be underestimated. Diarrhea is a common clinical …
View article: Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis
Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis Open
Background The objective of this study is to investigate the clinical and pathological differences between patients with IgA nephropathy (IgAN) and IgA vasculitis associated nephritis (IgAVN). Methods A total of 253 patients with IgAN and …
View article: Advances in the regulatory mechanisms of mTOR in necroptosis
Advances in the regulatory mechanisms of mTOR in necroptosis Open
The mammalian target of rapamycin (mTOR), an evolutionarily highly conserved serine/threonine protein kinase, plays a prominent role in controlling gene expression, metabolism, and cell death. Programmed cell death (PCD) is indispensable f…
View article: Altered expression of inflammation-associated molecules in striatum: an implication for sensitivity to heavy ion radiations
Altered expression of inflammation-associated molecules in striatum: an implication for sensitivity to heavy ion radiations Open
Background and objective Heavy ion radiation is one of the major hazards astronauts face during space expeditions, adversely affecting the central nervous system. Radiation causes severe damage to sensitive brain regions, especially the st…
View article: Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade
Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade Open
View article: Postoperative Adjuvant Transarterial Chemoembolization Plus Immunotherapy for Solitary Huge Hepatocellular Carcinoma without Macrovascular Invasion
Postoperative Adjuvant Transarterial Chemoembolization Plus Immunotherapy for Solitary Huge Hepatocellular Carcinoma without Macrovascular Invasion Open
Background and purpose The prognosis of patients with huge hepatocellular carcinoma (huge HCC, diameter ≥ 10 cm) is poor owing to the high early recurrence rate. This study aimed to explore the clinical value of postoperative adjuvant tran…
View article: Depletion of mTOR ameliorates CD4+ T cell pyroptosis by promoting autophagy activity in septic mice
Depletion of mTOR ameliorates CD4+ T cell pyroptosis by promoting autophagy activity in septic mice Open
A reduction in the number of CD4+ T cells is a central part of the immunosuppression phase of sepsis and leads to impaired immune defense ability and increased mortality. Pyroptosis, a newly discovered programmed cell…
View article: TLR7 promotes chronic airway disease in RSV-infected mice
TLR7 promotes chronic airway disease in RSV-infected mice Open
Respiratory syncytial virus (RSV) commonly infects the upper respiratory tract (URT) of humans, manifesting with mild cold or flu-like symptoms. However, in infants and the elderly, severe disease of the lower respiratory tract (LRT) often…
View article: Modulating functionally-distinct vagus nerve fibers using microelectrodes and kilohertz frequency electrical stimulation
Modulating functionally-distinct vagus nerve fibers using microelectrodes and kilohertz frequency electrical stimulation Open
Modulation of functionally distinct nerve fibers with bioelectronic devices provides a therapeutic opportunity for various diseases. In this study, we began by developing a computational model including four major subtypes of myelinated fi…
View article: Regulation of microglia polarization after cerebral ischemia
Regulation of microglia polarization after cerebral ischemia Open
Stroke ranks second as a leading cause of death and permanent disability globally. Microglia, innate immune cells in the brain, respond rapidly to ischemic injury, triggering a robust and persistent neuroinflammatory reaction throughout th…