Explanipedia

Analysis of depression prevalence and associated influencing factors in maintenance hemodialysis patients Open

Li Cao, Yongming Wu, Ruzhi Deng, Xinwen Zhang, Hehua Li , et al. · 2025

Background Hemodialysis is a common and effective treatment method for end-stage renal disease, but it is associated with adverse reactions, which may impair patients’ daily functioning and contribute to psychological burden. This study ai…

Corneal eccentricity and related factors in Chinese children and adolescents with astigmatism Open

Lei Zhou, Jieli Mao, Min Cao, C.-W. Wu, Mei Zhu , et al. · 2025

Müller-Lyer Illusion in Adults Increases with Age but Is Not Affected by Mild Visual Acuity Loss Open

Bichi Chen, Na Lin, Li Tian, Junfeng Mao, Maoyuan Yang , et al. · 2025

The intensity of Müller-Lyer illusion in adults is modulated by age but resistant to mild visual acuity loss, implicating its utility in studying visual-cognitive integration.

Intraocular pressure following long-term scleral lens wear in Chinese eyes Open

Maoyuan Yang, Feifu Wang, Aiqin Xu, Yang Qing, Ming He Cao , et al. · 2025

On average, IOP remained stable (mean changes < ± 0.3 mmHg) in Chinese participants with regular and irregular corneas following three months of scleral lens wear. Future long-term scleral lens studies examining changes in IOP with the len…

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1 Open

Na Sun, Yong‐Bing Wang, Jing Huang, Ruzhi Deng, Hui‐Yu He , et al. · 2025

Pulmonary vascular remodeling, which current therapeutic targets fail to alleviate disease severity, plays a key role in pulmonary arterial hypertension (PAH). Irisin is identified as a protective factor involved in regulating inflammation…

Machine learning-driven prediction of cycloplegic refractive error in Chinese children Open

Bichi Chen, Li Tian, Feng Tian, Yang Qing, Ying Ruan , et al. · 2025

Objective To develop and validate machine learning (ML) models for predicting cycloplegic spherical equivalent refraction (SER) using non-cycloplegic parameters, addressing challenges in pediatric ophthalmic assessments. Methods A prospect…

Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension Open

Xuan Gao, Youli Fan, Guanying Wang, Jiangjiang Xu, Ruzhi Deng , et al. · 2025

Sleep and mental status as key factors to asthenopia in Chinese adults Open

Na Lin, Xin Chen, Xiaotian Wu, Faming Tian, Maoyuan Yang , et al. · 2025

AIM: To investigate the occurrence of eye asthenopia in Chinese adults and pinpoint the factors contributing to it using a 17-item Asthenopia Survey Questionnaire (ASQ-17). METHODS: A total of 2509 Chinese adults aged 18 and above from 30 …

Nonlinear effects of humidex on risk for asthenopia among adults: a national cross-sectional survey in China Open

Xiaotian Wu, Xin Chen, Felicia F. Tian, Maoyuan Yang, Fan Lü , et al. · 2025

Introduction The health effects of ambient humidity and temperature are well-established. However, few studies have investigated the relationship between humidity, temperature, and asthenopia. Our goal was to quantify the impact of humidit…

How to Study the Effects of Dietary Lipids on the Small Intestinal Microbiome? Methodological Design and Evaluation of the Human HealThy fAt, haPpy mIcRobiome (TAPIR) Proof-of-Concept Study Open

Lonneke JanssenDuijghuijsen, Katrien Fransen, Ruzhi Deng, Corine Perenboom, Nicole de Wit , et al. · 2025

Breaking the Stigma! Unobtrusively Probe Symptoms in Depression Disorder Diagnosis Dialogue Open

Jieming Cao, Chen Huang, Yanan Zhang, Ruzhi Deng, Jincheng Zhang , et al. · 2025

Stigma has emerged as one of the major obstacles to effectively diagnosing depression, as it prevents users from open conversations about their struggles. This requires advanced questioning skills to carefully probe the presence of specifi…

Breaking the Stigma! Unobtrusively Probe Symptoms in Depression Disorder Diagnosis Dialogue Open

Jieming Cao, Chen Huang, Yanan Zhang, Ruzhi Deng, Jincheng Zhang , et al. · 2025

Distinct EEG Microstate Dynamics Characterize Major Depressive Disorder with and without Comorbid Anxiety Symptoms: Potential Neurophysiological Biomarkers for Subtyping Open

Yun Yi, Ruzhi Deng, Yuhua Wei, Hehua Li, Limei Pan , et al. · 2025

Prevalence and determinants of asthenopia among ophthalmologists in China: a national cross-sectional survey Open

Na Lin, Yu Zhu, Xiaotian Wu, Maoyuan Yang, Fan Lü , et al. · 2023

Introduction The role of ophthalmologists is defined by tasks requiring visual effort, emphasizing the importance of examining their condition within the realm of occupational visual health. Our goal was to explore the occurrence of asthen…

Low vision aids and age are associated with Müller-Lyer illusion in congenital visually impaired children Open

Na Lin, Bichi Chen, Maoyuan Yang, Fan Lü, Ruzhi Deng · 2023

Background The correlation between visual impairment and Müller-Lyer illusion is not yet elucidated. This study aimed to explore the connection between visual status, age, and the intensity of Müller-Lyer illusion in congenitally visually …

Repeatability and agreement of AOCT-1000 M, RTVue XR and IOL master 500 in measuring corneal thickness mapping and axial length applying principle of optical coherence tomography Open

Hailong Ni, Suzhong Xu, Li Tian, Jieli Mao, Jing Li , et al. · 2023

Development of a new 17-item Asthenopia Survey Questionnaire using Rasch analysis Open

Na Lin, Maoyuan Yang, Tian Li, Zhihua Li, Jie‐Li Mao , et al. · 2023

AIM: To develop the 17-item Asthenopia Survey Questionnaire (ASQ)-17 by Rasch analysis, and to generate a predictiveness score. METHODS: Totally 739 participants were recruited and 680 were involved in the result analysis in this prospecti…

[Mechanisms mediating the inhibitory effects of quercetin against phthalates-induced testicular oxidative damage in rats]. Open

Lei Liu, Ruzhi Deng, Wei Zhou, Mingxi Lin, Xia Liu , et al. · 2023

Quercetin treatment inhibits MPEs-induced oxidative testicular damage in rats possibly by direct scavenging of free radicals to lower testicular oxidative stress and restore the regulation of the Nrf2 signaling pathway.

Metrics of anterior sclera in normal Chinese adults: Anterior segment imaging using the swept-source optical coherence tomography Running Open

Na Lin, Yunqi Sun, Maoyuan Yang, Bichi Chen, Jieli Mao , et al. · 2023

Background: To measure the corneoscleral limbus and anterior sclera parameters of normal Chinese adults by swept-source optical coherence tomography (OCT). Methods: In this cross-sectional study, a total of 56 Chinese subjects with ametrop…

Performance of the AIDRScreening system in detecting diabetic retinopathy in the fundus photographs of Chinese patients: a prospective, multicenter, clinical study Open

Yaowen Yang, Jianying Pan, Miner Yuan, Kunbei Lai, Huirui Xie , et al. · 2022

The automated AIDRScreening system can detect RDR with high accuracy, but cannot detect maculopathy. The implementation of the AIDRScreening system may increase the efficiency of DR screening.

A new antioxidant made from a pterostilbene functionalized graphene nanocomposite as an efficient treatment for dry eye disease Open

Mimi Lin, Xueqin Sun, Sihao Ye, Youyi Chen, Jing Gao , et al. · 2022

Dry eye disease is a common condition that affects the eyes. It is caused by problems with the tear film and the tear dynamics. Dry eye can be caused by an increase in the amount of reactive oxygen species (ROS) in the corneal epithelium. …

Development of a new 17-item Asthenopia Survey Questionnaire(ASQ-17) using Rasch Analysis Open

Na Lin, Xiaoman Li, Li Tian, Zhihua Li, Jieli Mao , et al. · 2022

Purpose To develop a new 17-item Asthenopia Survey Questionnaire(ASQ-17) by Rasch analysis, and to evaluate a score to predict for its clinical application. Methods This cross-sectional study was conducted in the Eye Hospital of Wenzhou Me…

Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment Open

Wuhe Chen, Frank Thorn, Ruzhi Deng, Xiaoman Li, Jiangtao Lou , et al. · 2020

Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials …

Development of a Simple and Quick Method to Assess Base Editing in Human Cells Open

Xiujuan Lv, Kairui Qiu, Tianxiang Tu, Xiaoxue He, Yuchen Peng , et al. · 2020

The effect of a Computer Lens Filter on visual performance in subjects with retinitis pigmentosa Open

Zhangmei Guo, Lingzhi Ni, Na Lin, Yu Zhu, Longfei Jiang , et al. · 2020

Background： Retinitis pigmentosa (RP) patients usually complain about nyctalopia and reduced dark adaptation which cause their visual discomfort. In this study we aimed to explore the effects of a UV reduction Computer Lens Filter (CLF) on…

The Needs for Visual Improvement of Patients Presented at Low-Vision Center in Wenzhou, China Open

Xiaoman Li, Guofu Chen, Ruzhi Deng, Na Lin, Lingzhi Ni , et al. · 2019

Purpose . To characterize the needs for visual improvement of new-visit patients with low vision. Methods . This cross-sectional study collected detailed information of patients presented at low-vision center of the Eye Hospital of Wenzhou…

Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation Open

Ruzhi Deng, Xin Chen, Yun Zhang, Fang Bian, Ning Gao , et al. · 2019

The effect of a Computer Lens Filter on visual performance in subjects with retinitis pigmentosa Open

Zhangmei Guo, Lingzhi Ni, Na Lin, Yu Zhu, Longfei Jiang , et al. · 2019

Background：Retinitis pigmentosa (RP) patients uauslly complained nyctalopia and poor dark adaptation which caused their visual discomfort, in this study we aimed to explore the effects of a Computer Lens Filter (CLF) on contrast sensitivit…

A new efficient and comprehensive asthenopia questionnaire Open

Ruzhi Deng, Yanyan Lin, Jiafan Zhang, Yu Zhu, Jingwei Zheng , et al. · 2019

Background: There has been no standardized questionnaire and objective criterion for assessing and diagnosing asthenopia so far. This study aimed to design a valid and reliable questionnaire to determine the various causes of asthenopia fo…

Short-Term Effects of Overnight Orthokeratology on Corneal Sensitivity in Chinese Children and Adolescents Open

Wanqing Jin, Jiangping Ye, Jiafan Zhang, Yu Zhu, Frank Thorn , et al. · 2018

Purpose . To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods . Thirty subjects wore overnight OK lenses in both eyes for 3 months and were asses…

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