Ryan A. Brady
YOU?
Author Swipe
View article: Impacts of ribosomal RNA sequence variation on gene expression and phenotype
Impacts of ribosomal RNA sequence variation on gene expression and phenotype Open
Since the framing of the Central Dogma, it has been speculated that physically distinct ribosomes within cells may influence gene expression and cellular physiology. While heterogeneity in ribosome composition has been reported in bacteria…
View article: β-Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism
β-Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism Open
Templated synthesis of proteins containing non-natural amino acids (nnAAs) promises to expand the chemical space available to biological therapeutics and materials, but existing technologies are still limiting. Addressing these limitations…
Sculpting DNA-based synthetic cells through phase separation and phase-targeted activity Open
Synthetic cells, like their biological counterparts, require internal compartments with distinct chemical and physical properties where different functionalities can be localized. Inspired by membrane-less compartmentalization in biologica…
Influence of hydrophobic moieties on the crystallization of amphiphilic DNA nanostructures Open
Three-dimensional crystalline frameworks with nanoscale periodicity are valuable for many emerging technologies, from nanophotonics to nanomedicine. DNA nanotechnology has emerged as a prime route for constructing these materials, with mos…
Reaction–Diffusion Patterning of DNA-Based Artificial Cells Open
Biological cells display complex internal architectures with distinct micro environments that establish the chemical heterogeneity needed to sustain cellular functions. The continued efforts to create advanced cell mimics, namely, artifici…
Reaction-diffusion patterning of DNA-based artificial cells Open
Biological cells display complex internal architectures, with distinct micro environments that establish the chemical heterogeneity needed to sustain cellular functions. The continued efforts to create advanced cell mimics – artificial cel…
How lipids affect the energetics of co-translational alpha helical membrane protein folding Open
Membrane proteins need to fold with precision in order to function correctly, with misfolding potentially leading to disease. The proteins reside within a hydrophobic lipid membrane and must insert into the membrane and fold correctly, gen…
Cation-Responsive and Photocleavable Hydrogels from Noncanonical Amphiphilic DNA Nanostructures Open
Thanks to its biocompatibility, versatility, and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering, and drug delivery. Of …
Cation-responsive and photocleavable hydrogels from non-canonical amphiphilic DNA nanostructures Open
Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering and drug delivery. Of pa…
Cation-responsive and photocleavable hydrogels from non-canonical amphiphilic DNA nanostructures Open
Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering and drug delivery. Of pa…
Cation and light-responsive frameworks from non-canonical amphiphilic DNA nanostructures Open
Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering and drug delivery. Of pa…
Cation and light-responsive frameworks from non-canonical amphiphilic DNA nanostructures Open
Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering and drug delivery. Of pa…
Emerging Two-Dimensional Crystallization of Cucurbit[8]uril Complexes: From Supramolecular Polymers to Nanofibers Open
The binding of imidazolium salts to cucurbit[8]uril, CB[8], triggers a stepwise self-assembly process with semiflexible polymer chains and crystalline nanostructures as early- and late-stage species, respectively. In such a process, which …
Membrane Scaffolds Enhance the Responsiveness and Stability of DNA-Based Sensing Circuits Open
Target-induced DNA strand displacement is an excellent candidate for developing analyte-responsive DNA circuitry to be used in clinical diagnostics and synthetic biology. While most available technologies rely on DNA circuitry free to diff…
Research data supporting "Flexibility defines structure in crystals of amphiphilic DNA nanostars" Open
Zip folder containing raw 2D SAXS patterns of aggregates of each of the cholesterol functionalised DNA nanostar designs presented in the main text, in both buffer conditions tested. All SAXS data were collected at the Diamond Light Source,…
Research data supporting "Amphiphilic-DNA Platform for the Design of Crystalline Frameworks with Programmable Structure and Functionality" Open
Figure4_X: Confocal microscopy z-stacks and images of C-star aggregates soaked in fluorescent molecule X, used for the penetration assay presented in figure 4 of the associated publication. Figure 5: Confocal microscopy z-stacks and images…
Flexibility defines structure in crystals of amphiphilic DNA nanostars. Open
DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and b…
Amphiphilic-DNA Platform for the Design of Crystalline Frameworks with Programmable Structure and Functionality Open
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, al…
An Amphiphilic-DNA Platform for the Design of Crystalline Frameworks with Programmable Structure and Functionality Open
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, al…
An Amphiphilic-DNA Platform for the Design of Crystalline Frameworks with Programmable Structure and Functionality Open
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, al…
Crystalline frameworks self-assembled from amphiphilic DNA nanostructures Open
Many emerging technologies would greatly benefit from reliable methods for the production of functional materials with well-defined 3D nanoscale structure. Conceptually, approaches to produce such architectures are divided into two broad c…
Crystallization of Amphiphilic DNA C-Stars Open
Many emerging technologies require materials with well-defined three-dimensional nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building …
Research data supporting "Synthesis and Optical Properties of Lead-Free Cesium Tin Halide Perovskite Nanocrystals" Open
The uploaded data is the basis for all figures presented in the manuscript and the Supporting Information
Synthesis and Optical Properties of Lead-Free Cesium Tin Halide Perovskite Nanocrystals Open
Metal halide perovskite crystal structures have emerged as a class of optoelectronic materials, which combine the ease of solution processability with excellent optical absorption and emission qualities. Restricting the physical dimensions…