Ryan Braumann
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View article: Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy
Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy Open
Background Polygenic risk scores (PRS) for coronary artery disease (CAD) potentially improve cardiovascular risk prediction. However, their relationship with histopathologic features of CAD has never been examined systematically. Methods F…
View article: Genetic Variants Associated With Unexplained Sudden Cardiac Death in Adult White and African American Individuals
Genetic Variants Associated With Unexplained Sudden Cardiac Death in Adult White and African American Individuals Open
In this large genetic association study of community cases of unexplained SCD, nearly 20% of patients carried P/LP variants, suggesting that genetics may contribute to a significant number of cases of unexplained SCD. Our findings regardin…
View article: Vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans: impact on healing
Vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans: impact on healing Open
Aims Vascular calcification is routinely encountered in percutaneous coronary intervention (PCI) and severe coronary calcification is a known predictor of in-stent restenosis and stent thrombosis. However, the histopathologic mechanisms be…
View article: Genetics of Unexplained Sudden Cardiac Death in Adult Caucasian and African American Individuals Living in the State of Maryland
Genetics of Unexplained Sudden Cardiac Death in Adult Caucasian and African American Individuals Living in the State of Maryland Open
Background Unexplained-sudden cardiac death (SCD) describes SCD with no cause identified after a comprehensive autopsy and toxicologic examination. Genetic testing helps to diagnose inherited cardiac diseases in unexplained-SCD, however, t…
View article: CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis Open
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but import…
View article: Very Late Pathological Responses to Cobalt–Chromium Everolimus‐Eluting, Stainless Steel Sirolimus‐Eluting, and Cobalt–Chromium Bare Metal Stents in Humans
Very Late Pathological Responses to Cobalt–Chromium Everolimus‐Eluting, Stainless Steel Sirolimus‐Eluting, and Cobalt–Chromium Bare Metal Stents in Humans Open
Background The “very late” clinical outcomes for durable polymer drug‐eluting stents and bare metal stents ( BMSs ) have been shown to be dissimilar in clinical studies. Conceptually, the long‐term vascular compatibility of BMSs is still r…
View article: Heart-resident macrophages: are they involved in the rhythm of every beat?
Heart-resident macrophages: are they involved in the rhythm of every beat? Open
Macrophages are one of the main components of the innate immune system and play a major role in cardiovascular disease (1,2). These cells are derived from blood monocytes and differentiate into tissue macrophages. They are well known for t…