Ryan C. Chai
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View article: Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone
Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone Open
In inflammation, circulating neutrophils indirectly damage the skeleton by inducing formation of bone-resorbing osteoclasts. However, neutrophil progenitors in marrow have no known physiological function. A bone-protective role for the neu…
View article: Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease
Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease Open
Musculoskeletal diseases are a major global health burden. Development of new bone-active therapies is hindered by limited understanding of the complex interactions between the cells and genes that regulate the skeleton. To unravel this co…
View article: Bone niches in the regulation of tumour cell dormancy
Bone niches in the regulation of tumour cell dormancy Open
View article: Temporal patterns of osteoclast formation and activity following withdrawal of RANKL inhibition
Temporal patterns of osteoclast formation and activity following withdrawal of RANKL inhibition Open
Rebound bone loss following denosumab discontinuation is an important clinical challenge. Current treatment strategies to prevent this fail to suppress the rise and overshoot in osteoclast-mediated bone resorption. In this study, we use a …
View article: The potential of the proteome to predict fracture
The potential of the proteome to predict fracture Open
View article: ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor–ligand interactions that specify cell fate
ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor–ligand interactions that specify cell fate Open
Motivation Cell fate is commonly studied by profiling the gene expression of single cells to infer developmental trajectories based on expression similarity, RNA velocity, or statistical mechanical properties. However, current approaches d…
View article: ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor-ligand interactions that specify cell fate
ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor-ligand interactions that specify cell fate Open
Cell fate is commonly studied by profiling the gene expression of single cells to infer developmental trajectories based on expression similarity, RNA velocity, or statistical mechanical properties. However, current approaches do not recov…
View article: Single-Cell RNA Sequencing: Unravelling the Bone One Cell at a Time
Single-Cell RNA Sequencing: Unravelling the Bone One Cell at a Time Open
View article: Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease Open
View article: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption Open
View article: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption Open
View article: Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease
Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease Open
Osteocytes are master regulators of the skeleton. We mapped the transcriptome of osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and molecular programs that control this complex cellular-network. We d…
View article: A niche-dependent myeloid transcriptome signature defines dormant myeloma cells
A niche-dependent myeloid transcriptome signature defines dormant myeloma cells Open
The era of targeted therapies has seen significant improvements in depth of response, progression-free survival, and overall survival for patients with multiple myeloma. Despite these improvements in clinical outcome, patients inevitably r…
View article: Author Correction: An atlas of genetic influences on osteoporosis in humans and mice
Author Correction: An atlas of genetic influences on osteoporosis in humans and mice Open
View article: An atlas of genetic influences on osteoporosis in humans and mice
An atlas of genetic influences on osteoporosis in humans and mice Open
View article: An Atlas of Human and Murine Genetic Influences on Osteoporosis
An Atlas of Human and Murine Genetic Influences on Osteoporosis Open
Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone mineral density (BMD). We undertook a comprehensive assessment of human genetic determinants of bone density in 426,824 individuals, identifying a total o…
View article: Melphalan modifies the bone microenvironment by enhancing osteoclast formation
Melphalan modifies the bone microenvironment by enhancing osteoclast formation Open
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor developme…
View article: Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency
Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency Open
Mevalonate kinase (MVK) deficiency (MKD) is a rare, autosomal-recessive autoinflammatory disease that presents in its milder form as hyper-IgD syndrome (HIDS), and in the most severe cases as mevalonic aciduria (MVA).1 It is widely assumed…
View article: Histone deacetylase activity mediates acquired resistance towards structurally diverse <scp>HSP</scp> 90 inhibitors
Histone deacetylase activity mediates acquired resistance towards structurally diverse <span>HSP</span> 90 inhibitors Open
Heat shock protein 90 ( HSP 90) regulates multiple signalling pathways critical for tumour growth. As such, HSP 90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the sa…
View article: Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency (Letter to the Editor)
Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency (Letter to the Editor) Open
View article: Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases
Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases Open
Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate–cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin‐1β (IL‐1β). It is …
View article: A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients
A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients Open
View article: Additional file 3: Table S3. of A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients
Additional file 3: Table S3. of A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients Open
Summary of results for the detection of HPV-16-specific DNA and RNA in oral rinse of patients with p16INK4a-negative HNSCC (XLSX 38Â kb)
View article: Additional file 2: Table S2. of A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients
Additional file 2: Table S2. of A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients Open
Summary of results for the detection of HPV-16-specific DNA and RNA in oral rinse of patients with p16INK4a-positive HNSCC (XLSX 41Â kb)
View article: The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis
The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis Open
View article: Current trends in the etiology and diagnosis of <scp>HPV</scp>‐related head and neck cancers
Current trends in the etiology and diagnosis of <span>HPV</span>‐related head and neck cancers Open
Human papilloma virus ( HPV ) infection is a major risk factor for a distinct subset of head and neck squamous cell carcinoma ( HNSCC ). The current review summarizes the epidemiology of HNSCC and the disease burden, the infectious cycle o…