Ryan C. Murphy
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View article: Intravascular Leukocyte Labeling Refines the Distribution of Myeloid Cells in the Lung in Models of Allergen-induced Airway Inflammation
Intravascular Leukocyte Labeling Refines the Distribution of Myeloid Cells in the Lung in Models of Allergen-induced Airway Inflammation Open
Innate immune cell populations are critical in asthma with different functional characteristics based on tissue location, which has amplified the importance of characterizing the precise number and location of innate immune populations in …
View article: Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma
Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma Open
Rationale: Indirect airway hyperresponsiveness (AHR) is a highly specific feature of asthma, but the underlying mechanisms responsible for driving indirect AHR remain incompletely understood. Objectives: To identify differences in gene exp…
View article: Sputum periostin is a biomarker of type 2 inflammation but not airway dysfunction in asthma
Sputum periostin is a biomarker of type 2 inflammation but not airway dysfunction in asthma Open
Accurate phenotypic and endotypic characterization of asthma is critical to inform treatment decisions, particularly for patients with eosinophilic or type-2 (T2) high asthma who are more responsive to inhaled corticosteroids and are candi…
View article: Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma
Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma Open
Background Eosinophils are implicated as effector cells in asthma, but the functional implications of the precise location of eosinophils in the airway wall is poorly understood. We aimed to quantify eosinophils in the different compartmen…
View article: Epithelial Gene Expression in Relationship to Intra-Epithelial Innate Immune Cell Infiltration in Asthma
Epithelial Gene Expression in Relationship to Intra-Epithelial Innate Immune Cell Infiltration in Asthma Open
Rationale: We recently used quantitative morphometry to precisely partition the quantity of mast cells (MCs) and eosinophils (EOS) to the airway epithelium and submucosa in individuals with and without asthma who were extensively character…
View article: Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma
Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma Open
The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant de…
View article: Exploring the origin and regulatory role of mast cells in asthma
Exploring the origin and regulatory role of mast cells in asthma Open
Purpose of review Mast cells have previously been thought to function solely as effector cells in asthma but more recent studies have indicated that mast cells may play a more central role in propagating and regulating lower airway inflamm…
View article: C-type natriuretic peptide analog treatment of craniosynostosis in a Crouzon syndrome mouse model
C-type natriuretic peptide analog treatment of craniosynostosis in a Crouzon syndrome mouse model Open
Activating mutations of fibroblast growth factor receptors (FGFRs) are a major cause of skeletal dysplasias, and thus they are potential targets for pharmaceutical intervention. BMN 111, a C-type natriuretic peptide analog, inhibits FGFR s…
View article: Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen
Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen Open
Phospholipase A2 (PLA2) enzymes regulate the formation of eicosanoids and lysophospholipids that contribute to allergic airway inflammation. Secreted PLA2 group X (sPLA2-X) was recently found to be increased in the airways of asthmatics an…
View article: The antiviral effects of <scp>RSV</scp> fusion inhibitor, <scp>MDT</scp>‐637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin
The antiviral effects of <span>RSV</span> fusion inhibitor, <span>MDT</span>‐637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin Open
Background Respiratory syncytial virus ( RSV ) viral load and disease severity associate, and the timing of viral load and disease run in parallel. An antiviral must be broadly effective against the natural spectrum of RSV genotypes and mu…
View article: Deep sequencing of RSV from an adult challenge study and from naturally infected infants reveals heterogeneous diversification dynamics
Deep sequencing of RSV from an adult challenge study and from naturally infected infants reveals heterogeneous diversification dynamics Open
As RNA virus mutation occurs during replication within host cells, we hypothesized that viral evolution during acute infections in healthy hosts reflects host immune pressure. We therefore investigated the within-host diversification of hu…
View article: LION Surgery Broadcasts: Communal viewing benefits with perceived quality of transmission, surgery and discussion
LION Surgery Broadcasts: Communal viewing benefits with perceived quality of transmission, surgery and discussion Open
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