Ryan C. Vignogna
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View article: Tetraspanin TSP-12 and SUP-17/ADAM10 exhibit cell type–specific codependence for trafficking through the Golgi
Tetraspanin TSP-12 and SUP-17/ADAM10 exhibit cell type–specific codependence for trafficking through the Golgi Open
A subset of the four-pass transmembrane proteins called C8 tetraspanins (TspanC8) can bind and promote the cell surface localization of ADAM10 (A Disintegrin and Metalloproteinase 10). ADAM10 is a conserved transmembrane metalloprotease es…
View article: Female membrane proteins regulate postmating ovulation in <i>Drosophila melanogaster</i> by ovulin-dependent and -independent pathways
Female membrane proteins regulate postmating ovulation in <i>Drosophila melanogaster</i> by ovulin-dependent and -independent pathways Open
Ovulation is an intricate process that is essential for reproductive success. In Drosophila melanogaster , ovulation increases after mating. This increase is initiated by the male seminal fluid protein ovulin and is executed by female path…
View article: Structural basis for Rab6 activation by the Ric1-Rgp1 complex
Structural basis for Rab6 activation by the Ric1-Rgp1 complex Open
Rab GTPases act as molecular switches to regulate organelle homeostasis and membrane trafficking. Rab6 plays a central role in regulating cargo flux through the Golgi and is activated via nucleotide exchange by the Ric1-Rgp1 protein comple…
View article: Structural basis for Rab6 activation by the Ric1-Rgp1 complex
Structural basis for Rab6 activation by the Ric1-Rgp1 complex Open
Rab GTPases act as molecular switches to regulate organelle homeostasis and membrane trafficking. Rab6 plays a central role in regulating cargo flux through the Golgi and is activated via nucleotide exchange by the Ric1-Rgp1 protein comple…
View article: Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease
Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease Open
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2, which affect protein N -linked glycosylation. The yeast gene SEC53 encodes a homolog of human PMM2 . We evolved 3…
View article: Author response: Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease
Author response: Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract The most common cause of human conge…
View article: Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase
Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase Open
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2 , which affect protein N -linked glycosylation. The yeast gene SEC53 encodes a nearly-identical homolog of human P…
View article: Overdominant Mutations Restrict Adaptive Loss of Heterozygosity at Linked Loci
Overdominant Mutations Restrict Adaptive Loss of Heterozygosity at Linked Loci Open
Loss of heterozygosity is a common mode of adaptation in asexual diploid populations. Because mitotic recombination frequently extends the full length of a chromosome arm, the selective benefit of loss of heterozygosity may be constrained …
View article: Overdominant mutations restrict adaptive loss of heterozygosity at linked loci
Overdominant mutations restrict adaptive loss of heterozygosity at linked loci Open
Loss of heterozygosity is a common mode of adaptation in asexual diploid populations. Because mitotic recombination frequently extends the full length of a chromosome arm, the selective benefit of loss of heterozygosity may be constrained …
View article: Exploring a Local Genetic Interaction Network Using Evolutionary Replay Experiments
Exploring a Local Genetic Interaction Network Using Evolutionary Replay Experiments Open
Understanding how genes interact is a central challenge in biology. Experimental evolution provides a useful, but underutilized, tool for identifying genetic interactions, particularly those that involve non-loss-of-function mutations or m…
View article: Exploring a local genetic interaction network using evolutionary replay experiments
Exploring a local genetic interaction network using evolutionary replay experiments Open
Understanding how genes interact is a central challenge in biology. Experimental evolution provides a useful, but underutilized, tool for identifying genetic interactions, particularly those that involve non-loss-of-function mutations or m…
View article: Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae
Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae Open
Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repe…
View article: Cause and consequences of genome duplication in haploid yeast populations
Cause and consequences of genome duplication in haploid yeast populations Open
Whole genome duplications (WGD) represent important evolutionary events that shape future adaptation. WGDs are known to have occurred in the lineages leading to plants, fungi, and vertebrates. Changes to ploidy level impact the rate and sp…