Ryan D. Fine
YOU?
Author Swipe
View article: Hippo signaling pathway in cervical cancer: insights into mechanisms and therapeutic potential
Hippo signaling pathway in cervical cancer: insights into mechanisms and therapeutic potential Open
Cervical cancer (CC) remains a major global health threat to women, with persistent infection by high-risk human papillomavirus (HPV) being the primary etiological factor. In recent years, the Hippo signaling pathway has emerged as a criti…
View article: Joint disruption of <i>Ret</i> and <i>Ednrb</i> transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung disease
Joint disruption of <i>Ret</i> and <i>Ednrb</i> transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung disease Open
Despite extensive genetic heterogeneity, 72% of pathogenic alleles for Hirschsprung disease (HSCR) arise from coding and regulatory variants in genes of the RET and EDNRB gene regulatory network (GRN) in the enteric nervous system (ENS). T…
View article: The hidden dancers in water: the symbiotic mystery of Legionella pneumophila and free-living amoebae
The hidden dancers in water: the symbiotic mystery of Legionella pneumophila and free-living amoebae Open
Legionella pneumophila , a Gram-negative bacillus, is the primary etiological agent of Legionnaires’ disease, a severe respiratory infection. The symbiotic relationship between L. pneumophila and free-living amoebae (FLAs), particularly Ac…
View article: Joint disruption of <i>Ret</i> and <i>Ednrb</i> transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease
Joint disruption of <i>Ret</i> and <i>Ednrb</i> transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease Open
Despite extensive genetic heterogeneity, 72% of pathogenic alleles for Hirschsprung disease (HSCR) arise from coding and regulatory variants in genes of the RET and EDNRB gene regulatory network (GRN) in the enteric nervous system (ENS). R…
View article: Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III
Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III Open
Despite recent advances in single-molecule and structural analysis of condensin activity in vitro , mechanisms of functional condensin loading and loop extrusion that lead to specific chromosomal organization remain unclear. In Saccharomyc…
View article: Biological characteristics and pathogenicity of Acanthamoeba
Biological characteristics and pathogenicity of Acanthamoeba Open
Acanthamoeba is an opportunistic protozoa, which exists widely in nature and is mainly distributed in soil and water. Acanthamoeba usually exists in two forms, trophozoites and cysts. The trophozoite stage is one of growth and reproduction…
View article: Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III
Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III Open
Despite recent advances in single-molecule and structural analysis of condensin activity in vitro , mechanisms of functional condensin loading and loop extrusion that lead to specific chromosomal organization remain unclear. In Saccharomyc…
View article: A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism Open
Caloric restriction (CR) improves health span and life span of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging-associated diseases. In budding yeast, Saccharomyces …
View article: A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism Open
Caloric restriction (CR) improves healthspan and lifespan of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging associated diseases. In budding yeast, Saccharomyces ce…
View article: A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure
A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure Open
The NAD+-dependent histone deacetylase Sir2 was originally identified in Saccharomyces cerevisiae as a silencing factor for HML and HMR, the heterochromatic cassettes utilized as donor templates during mating-type switching. MATa cells pre…
View article: Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of <i>Saccharomyces cerevisiae</i>
Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of <i>Saccharomyces cerevisiae</i> Open
Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae. Within the yeast rDNA locus, Sir2 is require…
View article: A Sir2-regulated locus control region in the recombination enhancer of<i>Saccharomyces cerevisiae</i>specifies chromosome III structure
A Sir2-regulated locus control region in the recombination enhancer of<i>Saccharomyces cerevisiae</i>specifies chromosome III structure Open
The NAD + -dependent histone deacetylase Sir2 was originally identified in Saccharomyces cerevisiae as a silencing factor for HML and HMR , the heterochromatic cassettes utilized as donor templates during mating-type switching. MAT a cells…
View article: Depletion of limiting rDNA structural complexes triggers chromosomal instability and replicative aging of<i>Saccharomyces cerevisiae</i>
Depletion of limiting rDNA structural complexes triggers chromosomal instability and replicative aging of<i>Saccharomyces cerevisiae</i> Open
Sir2 is a highly conserved NAD + -dependent histone deacetylase that functions in heterochromatin formation and promotes replicative lifespan (RLS) in the budding yeast, Saccharomyces cerevisiae . Within the yeast rDNA locus, Sir2 is requi…
View article: Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK
Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK Open
Chronologically aging yeast cells are prone to adaptive regrowth, whereby mutants with a survival advantage spontaneously appear and re-enter the cell cycle in stationary phase cultures. Adaptive regrowth is especially noticeable with shor…
View article: RNA Polymerase I and Fob1 contributions to transcriptional silencing at the yeast rDNA locus
RNA Polymerase I and Fob1 contributions to transcriptional silencing at the yeast rDNA locus Open
RNA polymerase II (Pol II)-transcribed genes embedded within the yeast rDNA locus are repressed through a Sir2-dependent process called 'rDNA silencing'. Sir2 is recruited to the rDNA promoter through interactions with RNA polymerase I (Po…