Drew R. Jones
YOU?
Author Swipe
View article: Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy Open
Decreased brain levels of coenzyme Q10 (CoQ10), an endogenously synthesized lipophilic antioxidant1,2, underpin encephalopathy in primary CoQ10 deficiencies3,4 and are associated with common neurodegenerative diseases and the ageing proces…
View article: A shotgun approach for highly multiplexed mammalian metabolic engineering
A shotgun approach for highly multiplexed mammalian metabolic engineering Open
Mammalian metabolic engineering is critical to advancing basic biology, bioproduction, and cell therapy. However, as pathway complexity increases, so does the size of both the combinatorial design space and the DNA constructs required, ren…
View article: Contact Allergens in “PPD-Free” Hair Dyes
Contact Allergens in “PPD-Free” Hair Dyes Open
Background: Hair dyes are a commonly used cosmetic product and an important cause of allergic contact dermatitis (ACD). Primary hair dye agents, paraphenylenediamine (PPD) and other aromatic amines, are potent contact sensitizers. Despite…
View article: Sex differences in the levels of key mitochondrial markers in subjects with mild cognitive impairments and Alzheimer’s disease
Sex differences in the levels of key mitochondrial markers in subjects with mild cognitive impairments and Alzheimer’s disease Open
Introduction The lack of accessible plasma biomarkers to identify target populations limits the promise of precision medicine for Alzheimer’s Disease (AD). Amnestic mild cognitive impairment (aMCI) is an important risk for AD and often occ…
View article: P-308. Impactful Implementation of “HAPPI MRSA” - Hospital Onset Pneumonia Prevention and Reduction of Methicillin-Resistant <i>Staphylococcus aureus</i> Bloodstream Infections at a Large U.S. Health System
P-308. Impactful Implementation of “HAPPI MRSA” - Hospital Onset Pneumonia Prevention and Reduction of Methicillin-Resistant <i>Staphylococcus aureus</i> Bloodstream Infections at a Large U.S. Health System Open
Background Hospital onset (HO) Methicillin-Resistant Staphylococcus aureus (MRSA) bloodstream infection is one of the key performance metrics for the CMS Hospital-Acquired Condition (HAC) reduction payment program. MRSA bacteremia is a ser…
View article: Assessment of the brain metabolome following innate immunity stimulation in a non‐human primate model of sporadic CAA
Assessment of the brain metabolome following innate immunity stimulation in a non‐human primate model of sporadic CAA Open
Background Non‐human primates (NHP) serve as an important bridge for testing therapeutic agents that have been previously shown to be effective in transgenic mouse models. Our earlier published data using an NHP model of sporadic AD‐relate…
View article: DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy
DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathy Open
Mitochondrial dysfunction causes devastating disorders, including mitochondrial myopathy, but how muscle senses and adapts to mitochondrial dysfunction is not well understood. Here, we used diverse mouse models of mitochondrial myopathy to…
View article: Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens
Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens Open
Dehydration and malnutrition are common and often underdiagnosed in hospital settings. Multidrug-resistant bacterial infections result in more than 35,000 deaths a year in nosocomial patients. The effect of temporal dietary and water restr…
View article: Microbiota and metabolic adaptation shape<i>Staphylococcus aureus</i>virulence and antimicrobial resistance during intestinal colonization
Microbiota and metabolic adaptation shape<i>Staphylococcus aureus</i>virulence and antimicrobial resistance during intestinal colonization Open
Depletion of microbiota increases susceptibility to gastrointestinal colonization and subsequent infection by opportunistic pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). How the absence of gut microbiota impacts the…
View article: Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation Open
The development of dendritic cells (DCs), including antigen-presenting conventional DCs (cDCs) and cytokine-producing plasmacytoid DCs (pDCs), is controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. We genetically dis…
View article: Chemosensory detection of polyamine metabolites guides <i>C. elegans</i> to nutritive microbes
Chemosensory detection of polyamine metabolites guides <i>C. elegans</i> to nutritive microbes Open
Much is known about molecular mechanisms by which animals detect pathogenic microbes, but how animals sense beneficial microbes remains poorly understood. The roundworm Caenorhabditis elegans is a microbivore that must distinguish nutritiv…
View article: Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness
Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness Open
Background & Aims Despite increasing therapeutic options in the treatment of ulcerative colitis (UC), achieving disease remission remains a major clinical challenge. Nonresponse to therapy is common and clinicians have little guidance in s…
View article: DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy
DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy Open
Mitochondrial dysfunction causes devastating disorders, including mitochondrial myopathy. Here, we identified that diverse mitochondrial myopathy models elicit a protective mitochondrial integrated stress response (mt-ISR), mediated by OMA…
View article: UNAFFECTED RELATIVES WITH HIGH IBD POLYGENIC RISK SCORES FROM MULTIPLEX CROHN’S DISEASE FAMILIES CARRY MICROBIOMES THAT PROTECT IL-10 DEFICIENT MICE AGAINST INTESTINAL INFLAMMATION
UNAFFECTED RELATIVES WITH HIGH IBD POLYGENIC RISK SCORES FROM MULTIPLEX CROHN’S DISEASE FAMILIES CARRY MICROBIOMES THAT PROTECT IL-10 DEFICIENT MICE AGAINST INTESTINAL INFLAMMATION Open
Genetic and environmental influences contribute to Crohn’s disease (CD) development. However, the relationship between these two factors is unclear, limiting insights into CD pathophysiology, as well as interventions to prevent disease. To…
View article: Patient Subtyping Analysis of Baseline Multi-omic Data Reveals Distinct Pre-immune States Predictive of Vaccination Responses
Patient Subtyping Analysis of Baseline Multi-omic Data Reveals Distinct Pre-immune States Predictive of Vaccination Responses Open
Understanding the molecular mechanisms that underpin diverse vaccination responses is a critical step toward developing efficient vaccines. Molecular subtyping approaches can offer valuable insights into the heterogeneous nature of respons…
View article: The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability Open
SUMMARY Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their functional role in gliomagenesis and their potential as treatment target…
View article: Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease
Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease Open
Intestinal microbiome and metabolome signatures distinguished patients with CGD and CGD-IBD, and identified potential biomarkers and therapeutic targets.
View article: Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2 Open
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and can be targeted to treat neuropsychiatric and neurological disorders…