Ryan E. Schaub
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View article: A Novel Murine Model of Acute Laryngeal Injury After Intubation
A Novel Murine Model of Acute Laryngeal Injury After Intubation Open
Objective(s) Acute laryngeal injury (ALgI) occurs in over 50% of patients after intubation and mechanical ventilation and is associated with significantly worse voice, breathing, and swallowing outcomes. Currently, there are no small anima…
View article: IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube
IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube Open
The human pathogen Neisseria gonorrhoeae ascends into the upper female reproductive tract to cause damaging inflammation within the Fallopian tubes and pelvic inflammatory disease (PID), increasing the risk of infertility and ectopic pregn…
View article: Peptidoglycan fragment release and NOD activation by commensal <i>Neisseria</i> species from humans and other animals
Peptidoglycan fragment release and NOD activation by commensal <i>Neisseria</i> species from humans and other animals Open
Neisseria gonorrhoeae , a human restricted pathogen, releases inflammatory peptidoglycan (PG) fragments that contribute to the pathophysiology of pelvic inflammatory disease. The genus Neisseria is also home to multiple species of human- o…
View article: Peptidoglycan fragment release and NOD activation by commensal<i>Neisseria</i>species from humans and other animals
Peptidoglycan fragment release and NOD activation by commensal<i>Neisseria</i>species from humans and other animals Open
Neisseria gonorrhoeae , a human restricted pathogen, releases inflammatory peptidoglycan (PG) fragments that contribute to the pathophysiology of pelvic inflammatory disease. The genus Neisseria is also home to multiple species of human- o…
View article: Mutation of <i>mltG</i> increases peptidoglycan fragment release, cell size, and antibiotic susceptibility in <i>Neisseria gonorrhoeae</i>
Mutation of <i>mltG</i> increases peptidoglycan fragment release, cell size, and antibiotic susceptibility in <i>Neisseria gonorrhoeae</i> Open
Infection with Neisseria gonorrhoeae leads to inflammation that is responsible for the disease symptoms of gonococcal urethritis, cervicitis, and pelvic inflammatory disease. During growth, these bacteria release significant amounts of pep…
View article: Mutation of<i>mltG</i>increases peptidoglycan fragment release, cell size, and antibiotic susceptibility in<i>Neisseria gonorrhoeae</i>
Mutation of<i>mltG</i>increases peptidoglycan fragment release, cell size, and antibiotic susceptibility in<i>Neisseria gonorrhoeae</i> Open
Infection with the Gram-negative species Neisseria gonorrhoeae leads to inflammation that is responsible for the disease symptoms of gonococcal urethritis, cervicitis, and pelvic inflammatory disease. During growth these bacteria release s…
View article: A previously uncharacterized divisome-associated lipoprotein, DalA, is needed for normal cell division in <i>Rhodobacterales</i>
A previously uncharacterized divisome-associated lipoprotein, DalA, is needed for normal cell division in <i>Rhodobacterales</i> Open
The bacterial cell envelope is a key subcellular compartment with important roles in antibiotic resistance, nutrient acquisition, and cell morphology. We seek to gain a better understanding of proteins that contribute to the function of th…
View article: Mutational analysis of LtgC, a lytic transglycosylase required for cell separation in<i>Neisseria gonorrhoeae</i>
Mutational analysis of LtgC, a lytic transglycosylase required for cell separation in<i>Neisseria gonorrhoeae</i> Open
Lytic transglycosylases function to degrade peptidoglycan strands that comprise the bacterial cell wall. Degradation of peptidoglycan at the septum following cell division is necessary for cell separation, and a deletion of ltgC in Neisser…
View article: The AmiC/NlpD Pathway Dominates Peptidoglycan Breakdown in Neisseria meningitidis and Affects Cell Separation, NOD1 Agonist Production, and Infection
The AmiC/NlpD Pathway Dominates Peptidoglycan Breakdown in Neisseria meningitidis and Affects Cell Separation, NOD1 Agonist Production, and Infection Open
The human-restricted pathogen Neisseria meningitidis , which is best known for causing invasive meningococcal disease, has a nonpathogenic lifestyle as an asymptomatic colonizer of the human naso- and oropharyngeal space. N. meningitidis r…
View article: Expression, Localization, and Protein Interactions of the Partitioning Proteins in the Gonococcal Type IV Secretion System
Expression, Localization, and Protein Interactions of the Partitioning Proteins in the Gonococcal Type IV Secretion System Open
Partitioning proteins are well studied as molecular organizers of chromosome and plasmid segregation during division, however little is known about the roles partitioning proteins can play within type IV secretion systems. The single-stran…
View article: The AmiC/NlpD pathway dominates peptidoglycan breakdown in <i>Neisseria meningitidis</i> and affects cell separation, NOD1 agonist production, and infection
The AmiC/NlpD pathway dominates peptidoglycan breakdown in <i>Neisseria meningitidis</i> and affects cell separation, NOD1 agonist production, and infection Open
The human-restricted pathogen Neisseria meningitidis , which is best known for causing invasive meningococcal disease, has a nonpathogenic lifestyle as an asymptomatic colonizer of the human naso- and oropharyngeal space. N. meningitidis r…
View article: The NtrYX Two-Component System Regulates the Bacterial Cell Envelope
The NtrYX Two-Component System Regulates the Bacterial Cell Envelope Open
The bacterial cell envelope provides many important functions. It protects cells from harsh environments, serves as a selective permeability barrier, houses bioenergetic functions, defines sensitivity to antibacterial agents, and plays a c…
View article: Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis
Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis Open
Lytic transglycosylases (LT) are enzymes involved in peptidoglycan (PG) remodeling. However, their contribution to cell-wall-modifying complexes and their potential as antimicrobial drug targets remains unclear. Here, we determined a high-…
View article: Author response: Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis
Author response: Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Lytic transglycosylases (LT) …
View article: The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release
The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release Open
Neisseria gonorrhoeae and Neisseria meningitidis release peptidoglycan (PG) fragments from the cell as the bacteria grow. For N. gonorrhoeae these PG fragments are known to cause damage to human Fallopian tube tissue i…
View article: Peptidoglycan Composition in Neisseria
Peptidoglycan Composition in Neisseria Open
View article: <i>Neisseria gonorrhoeae</i> PBP3 and PBP4 Facilitate NOD1 Agonist Peptidoglycan Fragment Release and Survival in Stationary Phase
<i>Neisseria gonorrhoeae</i> PBP3 and PBP4 Facilitate NOD1 Agonist Peptidoglycan Fragment Release and Survival in Stationary Phase Open
Neisseria gonorrhoeae releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free pepti…
View article: The low‐molecular‐mass, penicillin‐binding proteins DacB and DacC combine to modify peptidoglycan cross‐linking and allow stable Type IV pilus expression in <i>Neisseria gonorrhoeae</i>
The low‐molecular‐mass, penicillin‐binding proteins DacB and DacC combine to modify peptidoglycan cross‐linking and allow stable Type IV pilus expression in <i>Neisseria gonorrhoeae</i> Open
Summary Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection gonorrhea and is adapted to survive in humans, its only host. The N. gonorrhoeae cell wall is critical for maintaining envelope integrity, resisting…
View article: Two lytic transglycosylases in<i>Neisseria gonorrhoeae</i>impart resistance to killing by lysozyme and human neutrophils
Two lytic transglycosylases in<i>Neisseria gonorrhoeae</i>impart resistance to killing by lysozyme and human neutrophils Open
Symptomatic infection by Neisseria gonorrhoeae (Gc) produces a potent inflammatory response, resulting in a neutrophil-rich exudate. A population of Gc can survive the killing activities of neutrophils for reasons not completely understood…
View article: Analysis of Peptidoglycan Fragment Release
Analysis of Peptidoglycan Fragment Release Open