Ryan J. Gilbert
YOU?
Author Swipe
View article: Perioperative Hyperglycemia is an Independent Risk Factor for Venous Thromboembolism Events After Operative Treatment of Geriatric Femur Fractures
Perioperative Hyperglycemia is an Independent Risk Factor for Venous Thromboembolism Events After Operative Treatment of Geriatric Femur Fractures Open
Introduction Geriatric femur fractures occur in complex hosts that pose significant challenges in perioperative management, with venous thromboembolism (VTE) as a well described complication. Hyperglycemia, prevalent in the perioperative p…
View article: Arthroscopic Repair With Side-to-Side Sutures for Full-Thickness Transtendinous Supraspinatus Tears Versus Traditional Tendon to Bone Fixation: Outcomes and Retear Rates at 4-Year Follow-up
Arthroscopic Repair With Side-to-Side Sutures for Full-Thickness Transtendinous Supraspinatus Tears Versus Traditional Tendon to Bone Fixation: Outcomes and Retear Rates at 4-Year Follow-up Open
Background: Full-thickness, transtendinous supraspinatus rotator cuff tears involve a significant portion of the remanent tendon attached to the footprint. Purpose: To compare outcomes and failure rates for arthroscopic side-to-side (STS) …
View article: Modular molecular design of polymerized pro-estrogen materials enables controlled astrocyte response
Modular molecular design of polymerized pro-estrogen materials enables controlled astrocyte response Open
Thermoplastic materials based on the polymerization of 17β-estradiol have demonstrated the ability to orchestrate astrocyte reactivity in vitro .
View article: Syndesmotic Screw Angle in Lateral Fibular Pre-Contoured Plates Impacts Quality of Syndesmotic Reduction: A Cadaveric Study
Syndesmotic Screw Angle in Lateral Fibular Pre-Contoured Plates Impacts Quality of Syndesmotic Reduction: A Cadaveric Study Open
Category: Ankle; Trauma Introduction/Purpose: Achieving adequate reduction of ankle syndesmosis after syndesmotic injury is critical as malreduction can lead to accelerated arthritis, pain, and instability. Static fixation with syndesmotic…
View article: Pharmacology of boldine: summary of the field and update on recent advances
Pharmacology of boldine: summary of the field and update on recent advances Open
Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been…
View article: Poster 154: Arthroscopic Rotator Cuff Repair With Side-to-Side Sutures for Full-Thickness Transtendinous Supraspinatus Tears Yields Excellent Outcomes and Low Retear Rates Similar to Traditional Tendon-to-Bone Fixation at Mean Follow Up of 4 Years
Poster 154: Arthroscopic Rotator Cuff Repair With Side-to-Side Sutures for Full-Thickness Transtendinous Supraspinatus Tears Yields Excellent Outcomes and Low Retear Rates Similar to Traditional Tendon-to-Bone Fixation at Mean Follow Up of 4 Years Open
Objectives: Full-thickness transtendinous supraspinatus tears involve a large portion of the tendon that remains attached to the footprint that often leaves insufficient medial tissue for tension free footprint restoration with traditional…
View article: Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro
Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro Open
A spinal cord injury (SCI) compresses the spinal cord, killing neurons and glia at the injury site and resulting in prolonged inflammation and scarring that prevents regeneration. Astrocytes, the main glia in the spinal cord, become reacti…
View article: Construction of an Elastin-like Polypeptide Gene in a High Copy Number Plasmid Using a Modified Method of Recursive Directional Ligation
Construction of an Elastin-like Polypeptide Gene in a High Copy Number Plasmid Using a Modified Method of Recursive Directional Ligation Open
Elastin-like polypeptides (ELPs) are popular biomaterials due to their reversible, temperature-dependent phase separation and their tunability, which is achievable by evolving procedures in recombinant technology. In particular, recursive …
View article: In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes
In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes Open
Multiple therapies have been studied to ameliorate the neuroinhibitory cues present after traumatic injury to the central nervous system. Two previous in vitro studies have demonstrated the efficacy of the Food and Drug Administration‐appr…
View article: Nanomaterial payload delivery to central nervous system glia for neural protection and repair
Nanomaterial payload delivery to central nervous system glia for neural protection and repair Open
Central nervous system (CNS) glia, including astrocytes, microglia, and oligodendrocytes, play prominent roles in traumatic injury and degenerative disorders. Due to their importance, active pharmaceutical ingredients (APIs) are being deve…
View article: Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease
Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease Open
Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water sol…
View article: Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes
Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes Open
Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical microelectrodes diminishes over time due, in part, to …
View article: Handheld PET Probe for Pediatric Cancer Surgery
Handheld PET Probe for Pediatric Cancer Surgery Open
18F-fluorodeoxyglucose (FDG) is a glucose analog that acts as a marker for glucose uptake and metabolism. FDG PET scans are used in monitoring pediatric cancers. The handheld PET probe localization of FDG-avid lesions is an emerging modali…
View article: Extracellular Matrix‐Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin‐Like Polypeptide Hydrogels
Extracellular Matrix‐Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin‐Like Polypeptide Hydrogels Open
Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)‐mimetic hydrogels are of particular interest as regenerative scaffolds f…
View article: Core-shell PLA nanofibers@SPIONs nanocomposites with enhanced properties for biomedical imaging and magnetic applications
Core-shell PLA nanofibers@SPIONs nanocomposites with enhanced properties for biomedical imaging and magnetic applications Open
International audience
View article: Acute Dose-Dependent Neuroprotective Effects of Poly(pro-17β-estradiol) in a Mouse Model of Spinal Contusion Injury
Acute Dose-Dependent Neuroprotective Effects of Poly(pro-17β-estradiol) in a Mouse Model of Spinal Contusion Injury Open
17β-Estradiol (E2) confers neuroprotection in preclinical models of spinal cord injury when administered systemically. The goal of this study was to apply E2 locally to the injured spinal cord for a sustained duration using poly(pro-E2) fi…
View article: Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration
Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration Open
Electrospinning is a fabrication technique used to produce nano- or micro- diameter fibers to generate biocompatible, biodegradable scaffolds for tissue engineering applications. Electrospun fiber scaffolds are advantageous for neural rege…
View article: Aligned Fingolimod-Releasing Electrospun Fibers Increase Dorsal Root Ganglia Neurite Extension and Decrease Schwann Cell Expression of Promyelinating Factors
Aligned Fingolimod-Releasing Electrospun Fibers Increase Dorsal Root Ganglia Neurite Extension and Decrease Schwann Cell Expression of Promyelinating Factors Open
Researchers are investigating the use of biomaterials with aligned guidance cues, like those provided by aligned electrospun fibers, to facilitate axonal growth across critical-length peripheral nerve defects. To enhance the regenerative o…
View article: Bone Marrow-Derived and Elicited Peritoneal Macrophages Are Not Created Equal: The Questions Asked Dictate the Cell Type Used
Bone Marrow-Derived and Elicited Peritoneal Macrophages Are Not Created Equal: The Questions Asked Dictate the Cell Type Used Open
Macrophages are a heterogeneous and plastic population of cells whose phenotype changes in response to their environment. Macrophage biologists utilize peritoneal (pMAC) and bone marrow-derived macrophages (BMDM) for in vitro studies. Give…
View article: Magnetic Composite Biomaterials for Neural Regeneration
Magnetic Composite Biomaterials for Neural Regeneration Open
Nervous system damage caused by physical trauma or degenerative diseases can result in loss of sensory and motor function for patients. Biomaterial interventions have shown promise in animal studies, providing contact guidance for extendin…