Ryan B. Griggs
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View article: Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)R4E alleviates chronic pain in type 2 diabetic mice
Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)R4E alleviates chronic pain in type 2 diabetic mice Open
Introduction: Pathological levels of methylglyoxal (MG), a reactive dicarbonyl product of glucose, contribute to major neurological complications associated with type II diabetes, including chronic neuropathic pain. Strategies to target el…
View article: The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels
The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels Open
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex …
View article: The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes
The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes Open
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or position along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex …
View article: Endoplasmic Reticulum Stress Induces Axon Initial Segment Shortening in Cortical Neuron Culture
Endoplasmic Reticulum Stress Induces Axon Initial Segment Shortening in Cortical Neuron Culture Open
The axon initial segment (AIS) is a domain located between the neuronal soma and axon responsible for action-potential initiation. Because even small changes in its length or location alter neuronal excitability and function, the AIS is a …
View article: Impairment of cognitive flexibility in type 2 diabetic db/db mice
Impairment of cognitive flexibility in type 2 diabetic db/db mice Open
View article: Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes Open
View article: Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice
Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice Open
Cognitive and mood impairments are common central nervous system complications of type 2 diabetes, although the neuronal mechanism(s) remains elusive. Previous studies focused mainly on neuronal inputs such as altered synaptic plasticity. …
View article: Glial βII Spectrin Contributes to Paranode Formation and Maintenance
Glial βII Spectrin Contributes to Paranode Formation and Maintenance Open
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na+ channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells i…
View article: Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation
Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation Open
Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive c…
View article: Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation
Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation Open
Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel tran…
View article: Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes
Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes Open
View article: Gabapentin alleviates affective pain after traumatic nerve injury
Gabapentin alleviates affective pain after traumatic nerve injury Open
Gabapentin reduces behavioral signs of stimulus-evoked allodynia and hyperalgesia in preclinical studies of traumatic nerve injury, but its effects on more clinically relevant measures of stimulus-independent pain are unclear. To address t…
View article: Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms Open
Repeated administration of peroxisome proliferator-activated receptor gamma (PPARγ) agonists reduces neuropathic pain-like behavior and associated changes in glial activation in the spinal cord dorsal horn. As PPARγ is a nuclear receptor, …
View article: TARGETING METHYLGLYOXAL AND PPAR GAMMA TO ALLEVIATE NEUROPATHIC PAIN ASSOCIATED WITH TYPE 2 DIABETES
TARGETING METHYLGLYOXAL AND PPAR GAMMA TO ALLEVIATE NEUROPATHIC PAIN ASSOCIATED WITH TYPE 2 DIABETES Open
Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States. Neuropathic pain in diabetes manifests as a disease of the peripheral and central nervous systems. The prevalence of type 2 diabetes is far greate…