Ryan Guasp
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View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Author response: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Author response: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles…
View article: Reviewer #1 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Reviewer #1 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Reviewer #3 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Reviewer #3 (Public Review): Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons Open
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, su…
View article: Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed<i>C. elegans</i>Neurons and Influence Large Vesicle Extrusions as Exophers
Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed<i>C. elegans</i>Neurons and Influence Large Vesicle Extrusions as Exophers Open
Under conditions of proteostasis disequilibrium, neurons can enhance intracellular and extracellular protective mechanisms to guard against neurotoxicity. In mammals, an intracellular response to severe proteostasis imbalance that results …
View article: Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling
Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling Open
Significance In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal p…