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View article: Abstract 459: A Tale of Two Sisters: Intracerebral Hemorrhage with COL4A1 Gene Variant Case Series
Abstract 459: A Tale of Two Sisters: Intracerebral Hemorrhage with COL4A1 Gene Variant Case Series Open
Introduction Spontaneous intracerebral hemorrhage (sICH) accounts for 10‐20% of all strokes and is a significant cause of disability and mortality. While commonly linked to factors such as hypertension and amyloid angiopathy, sICH can also…
View article: Disparities in Cardiovascular Disease in Women with Adverse Pregnancy Outcomes
Disparities in Cardiovascular Disease in Women with Adverse Pregnancy Outcomes Open
Background Although adverse pregnancy outcomes (APOs) have been linked to increased cardiovascular disease (CVD) risk, most studies have focused on homogenous populations. We tested the hypothesis that APOs and race and ethnicity synergist…
View article: Minimally Invasive Surgery vs Medical Management Alone for Intracerebral Hemorrhage
Minimally Invasive Surgery vs Medical Management Alone for Intracerebral Hemorrhage Open
Importance It remains uncertain whether surgical evacuation improves functional outcomes in patients with supratentorial intracerebral hemorrhage (ICH). Objective To compare the safety and efficacy of minimally invasive surgery with the Ar…
View article: Characterizing Stroke Clots Using Single‐Cell Sequencing
Characterizing Stroke Clots Using Single‐Cell Sequencing Open
Background Ischemic stroke results in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potentia…
View article: Molecular Mechanisms of Gain-of-Function Mutations in λ Cro Revealed by Molecular Dynamics Simulations
Molecular Mechanisms of Gain-of-Function Mutations in λ Cro Revealed by Molecular Dynamics Simulations Open
Transcription factors regulate gene expression by coordinating complex networks in organisms ranging from bacteriophages to humans. Bacteriophage λ Cro is a 66-residue repressor that binds DNA as a dimer to block transcription. Because of …
View article: Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series: Corrigendum
Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series: Corrigendum Open
[This corrects the article DOI: 10.1227/neuprac.0000000000000113.].
View article: Traumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management
Traumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management Open
Vertebral artery injury (VAI) is a known complication of blunt cervical spine trauma with a potential risk of stroke. Factors including cervical bony injury, spinal cord injury, and overall trauma severity have been linked to an increased …
View article: Impact of Social Determinants of Health on Outcomes of Nontraumatic Subarachnoid Hemorrhage
Impact of Social Determinants of Health on Outcomes of Nontraumatic Subarachnoid Hemorrhage Open
Background Nontraumatic subarachnoid hemorrhage (SAH) presents a significant health burden, yet the influence of social determinants of health on outcomes remains unclear. This study examines the impact of social determinants of health on …
View article: Deciphering the Molecular Mechanisms of BPTF Interactions with Nucleosomes via Molecular Simulations
Deciphering the Molecular Mechanisms of BPTF Interactions with Nucleosomes via Molecular Simulations Open
Many transcription factors regulate DNA accessibility and gene expression by recognizing post-translational modifications on histone tails within nucleosomes. These interactions are often studied in vitro using short peptide mimics of hist…
View article: Non-invasive approach for endoluminal biopsy coupled with single-cell proteomics allows for immune characterization of intracranial aneurysms
Non-invasive approach for endoluminal biopsy coupled with single-cell proteomics allows for immune characterization of intracranial aneurysms Open
The immune regulatory mechanisms driving the stability, growth, and rupture of intracranial aneurysms (IAs) remain incompletely understood. In this study, we employ endoluminal biopsy with single-cell proteomics to comprehensively profile …
View article: Characterizing Stroke Clots Using Single-Cell Sequencing
Characterizing Stroke Clots Using Single-Cell Sequencing Open
Background Ischemic stroke result in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potential…
View article: Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series
Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series Open
BACKGROUND AND OBJECTIVES: Neurosurgical management of idiopathic intracranial hypertension (IIH) can be challenging given high rates of revision associated with cerebrospinal fluid shunting. In this study, we present a technical report an…
View article: Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis
Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis Open
Background Prior studies have suggested an association between clot histological composition and cause of stroke. However, the results have been conflicting. Our objective is to provide an updated systematic review and meta‐analysis of the…
View article: Angiographic evidence of an inadvertent cannulation of the marginal sinus following central line migration: illustrative case
Angiographic evidence of an inadvertent cannulation of the marginal sinus following central line migration: illustrative case Open
BACKGROUND Central venous catheters (CVCs) play an indispensable role in clinical practice. Catheter malposition and tip migration can lead to severe complications. The authors present a case illustrating the endovascular management of ina…
View article: Migration of Iophendylate Myelography Contrast to the Brain With Successful Thrombectomy
Migration of Iophendylate Myelography Contrast to the Brain With Successful Thrombectomy Open
A 77-year-old woman with hypertension and atrial fibrillation presented 1.5 hours after acute onset of aphasia and right hemibody weakness, NIHSS 16.NCCT showed no acute changes; CTA left M1 near-occlusion; CTP no core infarct, 26cc penumb…
View article: Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury Open
Background Timely imaging is essential for patients undergoing mechanical thrombectomy (MT). Our objective was to evaluate the safety and feasibility of low‐field portable magnetic resonance imaging (pMRI) for bedside evaluation following …
View article: O-068 Regulatory B cell and adjunctive immune population drives intracranial aneurysm rupture in patient population
O-068 Regulatory B cell and adjunctive immune population drives intracranial aneurysm rupture in patient population Open
Introduction Dynamic flow models have been useful in describing the development of intracranial aneurysms. However, our understanding of the mechanisms behind their remodeling and rupture is limited. Given that only a subset of patients wh…
View article: Higher Hospital Frailty Risk Score is associated with increased complications and healthcare resource utilization after endovascular treatment of ruptured intracranial aneurysms
Higher Hospital Frailty Risk Score is associated with increased complications and healthcare resource utilization after endovascular treatment of ruptured intracranial aneurysms Open
Aim To use the Hospital Frailty Risk Score (HFRS) to investigate the impact of frailty on complication rates and healthcare resource utilization in patients who underwent endovascular treatment of ruptured intracranial aneurysms (IAs). Met…
View article: Effect of Hispanic Status in Mechanical Thrombectomy Outcomes After Ischemic Stroke: Insights From STAR
Effect of Hispanic Status in Mechanical Thrombectomy Outcomes After Ischemic Stroke: Insights From STAR Open
Background and Purpose: Epidemiological studies have shown racial and ethnic minorities to have higher stroke risk and worse outcomes than non-Hispanic Whites. In this cohort study, we analyzed the STAR (Stroke Thrombectomy and Aneurysm Re…
View article: Transcarotid artery revascularization (TCAR): a technical video
Transcarotid artery revascularization (TCAR): a technical video Open
Carotid revascularization is an important method of stroke prevention and includes carotid endarterectomy and transfemoral carotid angioplasty and stenting. More recently, a hybrid open-endovascular approach, termed transcarotid artery rev…
View article: Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access
Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access Open
OBJECTIVE While the benefit of mechanical thrombectomy (MT) for patients with anterior circulation acute ischemic stroke with large-vessel occlusion (AIS-LVO) has been clearly established, difficult vascular access may make the interventio…
View article: Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic
Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic Open
Background: Anecdotal reports suggest fewer patients with stroke symptoms are presenting to hospitals during the coronavirus disease 2019 (COVID-19) pandemic. We quantify trends in stroke code calls and treatments at 3 Connecticut hospital…
View article: Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke Open
Background and Purpose— Loss of cerebral autoregulation in the acute phase of ischemic stroke leaves patients vulnerable to blood pressure (BP) changes. Effective BP management after endovascular thrombectomy may protect the brain from hyp…