Ryan D. Hernandez
YOU?
Author Swipe
View article: Urinary Acetaminophen Metabolites and Clinical Outcomes in Extremely Premature Infants
Urinary Acetaminophen Metabolites and Clinical Outcomes in Extremely Premature Infants Open
Extremely premature infants are treated with acetaminophen (APAP) for pain and patent ductus arteriosus. High doses of APAP in adults are toxic, and a recent study found an association between APAP metabolite levels in mothers' breast milk…
View article: Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas Open
Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for conse…
View article: PROPEL: a scalable model for postbaccalaureate training to promote diversity in the biomedical workforce
PROPEL: a scalable model for postbaccalaureate training to promote diversity in the biomedical workforce Open
Promoting diversity in the scientific workforce is crucial for harnessing the potential of available talent and ensuring equitable access to Science, Technology, Engineering, Mathematics, and Medicine (STEM-M) careers. We have developed an…
View article: Urinary acetaminophen metabolites and clinical outcomes in premature infants
Urinary acetaminophen metabolites and clinical outcomes in premature infants Open
BACKGROUND Extremely premature infants are treated with acetaminophen (APAP) for discomfort and patent ductus arteriosus. A recent study found an association between APAP metabolite levels in mothers’ breast milk and the diagnoses of both …
View article: PROPEL: a scalable model for postbaccalaureate training to promote diversity in the biomedical workforce
PROPEL: a scalable model for postbaccalaureate training to promote diversity in the biomedical workforce Open
Promoting diversity in the scientific workforce is crucial for harnessing the potential of available talent and ensuring equitable access to Science, Technology, Engineering, Mathematics, and Medicine (STEM-M) careers. We have developed an…
View article: py_ped_sim - A flexible forward genetic simulator for complex family pedigree analysis
py_ped_sim - A flexible forward genetic simulator for complex family pedigree analysis Open
Background Large-scale family pedigrees are commonly used across medical, evolutionary, and forensic genetics. These pedigrees are tools for identifying genetic disorders, tracking evolutionary patterns, and establishing familial relations…
View article: The Urinary Metabolomic Fingerprint in Extremely Preterm Infants on Total Parenteral Nutrition vs. Enteral Feeds
The Urinary Metabolomic Fingerprint in Extremely Preterm Infants on Total Parenteral Nutrition vs. Enteral Feeds Open
Total Parenteral Nutrition (TPN), which uses intravenous administration of nutrients, minerals and vitamins, is essential for sustaining premature infants until they transition to enteral feeds, but there is limited information on metabolo…
View article: Efficacy of National Comprehensive Cancer Network Guidelines in Identifying Pathogenic Germline Variants Among Unselected Patients with Prostate Cancer: The PROCLAIM Trial
Efficacy of National Comprehensive Cancer Network Guidelines in Identifying Pathogenic Germline Variants Among Unselected Patients with Prostate Cancer: The PROCLAIM Trial Open
One in 13 patients with prostate cancer carries an inherited variant that may be actionable for the patient's current care or prevention of future cancer, and could benefit from expanded testing criteria.
View article: The Urinary Metabolomic Fingerprint in Extremely Preterm Infants on Total Parenteral Nutrition vs Enteral Feeds
The Urinary Metabolomic Fingerprint in Extremely Preterm Infants on Total Parenteral Nutrition vs Enteral Feeds Open
Total Parenteral Nutrition (TPN), which uses intravenous administration of nutrients, minerals and vitamins, is essential in sustaining premature infants until they transition to enteral feeds. There is limited information on metabolomic d…
View article: The hydrocortisone-responsive urinary metabolome of premature infants
The hydrocortisone-responsive urinary metabolome of premature infants Open
Background Extremely premature infants are at risk for circulatory collapse or respiratory failure that are often treated with hydrocortisone (HC); however, there is no information on the metabolic consequences of this therapy. Methods Lon…
View article: Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial
Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial Open
This is a substudy (BE29353) of the OPERA I (WA21092; NCT01247324) trial. Date of registration, November 23, 2010; first patient enrollment, August 31, 2011.
View article: Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex
Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex Open
We developed novel closed-form estimators of genetic and environmental correlation coefficients. We applied them to estimate over 4,000 genetic and environmental correlations between multiple phenotypes in a diverse sample from the Trans-O…
View article: Population sequencing data reveal a compendium of mutational processes in the human germ line
Population sequencing data reveal a compendium of mutational processes in the human germ line Open
Gauging the spectrum of human mutations It has become increasing clear that mutation affects phenotypic variation and disease risk across humans. However, there are many different types of mutation. Seplyarskiy et al . applied a matrix fac…
View article: Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits
Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits Open
People in the Americas represent a diverse continuum of populations with varying degrees of admixture among African, European, and Amerindigenous ancestries. In the United States, populations with non-European ancestry remain understudied,…
View article: A <i>Cutibacterium acnes</i> antibiotic modulates human skin microbiota composition in hair follicles
A <i>Cutibacterium acnes</i> antibiotic modulates human skin microbiota composition in hair follicles Open
Cutimycin, a thiopeptide antibiotic produced by the skin commensal Cutibacterium acnes , reduces Staphylococcus colonization of human skin hair follicles.
View article: A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome Open
The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of …
View article: The Temporal Dynamics of Background Selection in Nonequilibrium Populations
The Temporal Dynamics of Background Selection in Nonequilibrium Populations Open
Neutral genetic diversity across the genome is determined by the complex interplay of mutation, demographic history, and natural selection. While the direct action of natural selection is limited to functional loci across the genome, its i…
View article: De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population
De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population Open
De novo mutations (DNMs), or mutations that appear in an individual despite not being seen in their parents, are an important source of genetic variation whose impact is relevant to studies of human evolution, genetics, and disease. Utiliz…
View article: Recent fluctuations in Mexican American genomes have altered the genetic architecture of biomedical traits
Recent fluctuations in Mexican American genomes have altered the genetic architecture of biomedical traits Open
People in the Americas represent a diverse group of populations with varying degrees of admixture among African, European, and Amerindigenous ancestries. In the United States, many populations with non-European ancestry remain understudied…
View article: Population sequencing data reveal a compendium of mutational processes in human germline
Population sequencing data reveal a compendium of mutational processes in human germline Open
Mechanistic processes underlying human germline mutations remain largely unknown. Variation in mutation rate and spectra along the genome is informative about the biological mechanisms. We statistically decompose this variation into separa…
View article: Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits
Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits Open
The genetic architecture of complex human traits remains largely unknown. The distribution of heritability across the minor allele frequency (MAF) spectrum for a trait will be a function of the MAF of its causal variants and their effect s…
View article: Population genetic simulation study of power in association testing across genetic architectures and study designs
Population genetic simulation study of power in association testing across genetic architectures and study designs Open
While it is well established that genetics can be a major contributor to population variation of complex traits, the relative contributions of rare and common variants to phenotypic variation remains a matter of considerable debate. Here, …